WT1 and PAWR

Number of citations of the paper that reports this interaction (PMID 8943350)
44

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo, two hybrid)

		WT1	PAWR
Gene Name		Wilms tumor 1	PRKC, apoptosis, WT1, regulator
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Nuclear Speck	Nucleus Cytoplasm Actin Filament Plasma Membrane Actin Cytoskeleton
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity RNA Binding Protein Binding Zinc Ion Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding C2H2 Zinc Finger Domain Binding	Transcription Corepressor Activity Actin Binding Protein Binding Enzyme Binding Leucine Zipper Domain Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Vasculogenesis Ureteric Bud Development Branching Involved In Ureteric Bud Morphogenesis Kidney Development Regulation Of Organ Formation Transcription, DNA-templated Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Germ Cell Development Thorax And Anterior Abdomen Determination Heart Development Sex Determination Negative Regulation Of Cell Proliferation RNA Splicing Gonad Development Male Gonad Development Tissue Development Negative Regulation Of Translation Negative Regulation Of Cell Growth Adrenal Gland Development Male Genitalia Development Epithelial Cell Differentiation Glomerulus Development Glomerular Basement Membrane Development Adrenal Cortex Formation Camera-type Eye Development Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Mesenchymal To Epithelial Transition Positive Regulation Of Heart Growth Diaphragm Development Cardiac Muscle Cell Fate Commitment Visceral Serous Pericardium Development Cellular Response To CAMP Cellular Response To Gonadotropin Stimulus Metanephric Mesenchyme Development Glomerular Visceral Epithelial Cell Differentiation Posterior Mesonephric Tubule Development Metanephric Epithelium Development Metanephric S-shaped Body Morphogenesis Negative Regulation Of Metanephric Glomerular Mesangial Cell Proliferation Positive Regulation Of Male Gonad Development Negative Regulation Of Female Gonad Development Positive Regulation Of Metanephric Ureteric Bud Development	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Apoptotic Process Negative Regulation Of Cell Proliferation Negative Regulation Of B Cell Proliferation Interleukin-2 Biosynthetic Process Negative Regulation Of T Cell Proliferation Positive Regulation Of Amyloid Precursor Protein Biosynthetic Process Positive Regulation Of Apoptotic Process Negative Regulation Of T Cell Receptor Signaling Pathway Actin Filament Bundle Assembly Apoptotic Signaling Pathway
Pathways
Drugs
Diseases
GWAS		Tuberculosis ( 22306650)	Attention deficit hyperactivity disorder and conduct disorder ( 18951430)
Protein-Protein Interactions		23 interactors: AREG CIAO1 CREBBP DVL3 EGR1 FHL2 KRT40 KRTAP10-3 KRTAP10-8 MDM2 NPM3 PAWR PAX2 PRKACA TAOK1 TP53 TP63 TP73 U2AF2 UBE2I WTAP WTIP ZNF205	17 interactors: AATF ATP5C1 DAPK3 DRD2 FBXO45 HSPA5 PML PRKCZ RRAS2 SLC5A7 SPSB1 SPSB2 SPSB4 SQSTM1 TFPT THAP1 WT1
Entrez ID		7490	5074
HPRD ID		06163	09051
Ensembl ID		ENSG00000184937
Uniprot IDs		P19544 Q6PI38	Q96IZ0
PDB IDs		1LU6 1XF7 2G7T 2G7V 2G7W 2G7X 2JP9 2JPA 2PRT 3HPJ 3MYJ	2JK9
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Biosynthetic Process Cellular Response To Radiation Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Cellular Response To Light Stimulus Regulation Of Gene Expression Regulation Of Signal Transduction Gene Expression Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Apoptotic Process Regulation Of Cell Proliferation Response To Gamma Radiation Response To Abiotic Stimulus Regulation Of Signaling Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of Cell Death DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator RNA Metabolic Process DNA Damage Checkpoint Cellular Response To UV DNA Damage Response, Signal Transduction Resulting In Transcription Mitotic G1 DNA Damage Checkpoint Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Transcription, DNA-templated DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Nucleic Acid-templated Transcription Apoptotic Process Regulation Of RNA Biosynthetic Process Negative Regulation Of Cell Death Programmed Cell Death Signal Transduction In Response To DNA Damage Cell Death Death Mitotic DNA Damage Checkpoint	Regulation Of Cell Death Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Positive Regulation Of Cell Death Apoptotic Signaling Pathway Cellular Response To Stimulus Signaling Cell Communication Signal Transduction Negative Regulation Of Translation Apoptotic Process Programmed Cell Death Regulation Of Protein Metabolic Process Cell Death Death Response To Stimulus Cellular Metabolic Process Response To Organic Substance Cellular Response To Organic Substance Regulation Of Mitotic Cell Cycle Response To Stress Regulation Of Cellular Protein Metabolic Process Establishment Of Localization In Cell Long-term Memory Negative Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Cell Cycle Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Cellular Response To Interleukin-4 Cellular Response To Stress Negative Regulation Of Cell Death Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Response To Interleukin-4 Protein Ubiquitination Cellular Response To Growth Factor Stimulus Regulation Of Nitrogen Compound Metabolic Process Regulation Of Protein Phosphorylation Regulation Of Cell Migration Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Morphogenesis Of A Branching Structure Response To Growth Factor Proteasomal Protein Catabolic Process Protein Modification By Small Protein Conjugation Negative Regulation Of Translation In Response To Oxidative Stress
Tagcloud ?		al antisense discovery enhance et evidence genomic humans igf2r imprinted imprinting issue locus might moorwood murine particularly recent regulating relate rna since suppressor transcript transcripts tumour typically unusual wilms	aggravating airway airways asthma asthmatic ats cawr coexisting expiratory fev1 forced fvc gastroesophageal gerd hz impulse ios ninety oscillometry pef plethysmography presences reflux representative sec severity tawr verified vital
Tagcloud (Difference) ?		al antisense discovery enhance et evidence genomic humans igf2r imprinted imprinting issue locus might moorwood murine particularly recent regulating relate rna since suppressor transcript transcripts tumour typically unusual wilms	aggravating airway airways asthma asthmatic ats cawr coexisting expiratory fev1 forced fvc gastroesophageal gerd hz impulse ios ninety oscillometry pef plethysmography presences reflux representative sec severity tawr verified vital
Tagcloud (Intersection) ?