WT1 and WTIP

Number of citations of the paper that reports this interaction (PMID 14736876)
21

Data Source:
HPRD (in vivo, in vitro, two hybrid)

		WT1	WTIP
Gene Name		Wilms tumor 1	Wilms tumor 1 interacting protein
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Nuclear Speck	Cytoplasmic MRNA Processing Body Nucleus Adherens Junction
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity RNA Binding Protein Binding Zinc Ion Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding C2H2 Zinc Finger Domain Binding	Transcription Corepressor Activity Protein Binding Zinc Ion Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Vasculogenesis Ureteric Bud Development Branching Involved In Ureteric Bud Morphogenesis Kidney Development Regulation Of Organ Formation Transcription, DNA-templated Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Germ Cell Development Thorax And Anterior Abdomen Determination Heart Development Sex Determination Negative Regulation Of Cell Proliferation RNA Splicing Gonad Development Male Gonad Development Tissue Development Negative Regulation Of Translation Negative Regulation Of Cell Growth Adrenal Gland Development Male Genitalia Development Epithelial Cell Differentiation Glomerulus Development Glomerular Basement Membrane Development Adrenal Cortex Formation Camera-type Eye Development Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Mesenchymal To Epithelial Transition Positive Regulation Of Heart Growth Diaphragm Development Cardiac Muscle Cell Fate Commitment Visceral Serous Pericardium Development Cellular Response To CAMP Cellular Response To Gonadotropin Stimulus Metanephric Mesenchyme Development Glomerular Visceral Epithelial Cell Differentiation Posterior Mesonephric Tubule Development Metanephric Epithelium Development Metanephric S-shaped Body Morphogenesis Negative Regulation Of Metanephric Glomerular Mesangial Cell Proliferation Positive Regulation Of Male Gonad Development Negative Regulation Of Female Gonad Development Positive Regulation Of Metanephric Ureteric Bud Development	Response To Hypoxia Transcription, DNA-templated Regulation Of Transcription, DNA-templated Cytoskeleton Organization Regulation Of Cell Morphogenesis Gene Silencing By MiRNA Negative Regulation Of Hippo Signaling Negative Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Gene Silencing By MiRNA
Pathways
Drugs
Diseases
GWAS		Tuberculosis ( 22306650)
Protein-Protein Interactions		23 interactors: AREG CIAO1 CREBBP DVL3 EGR1 FHL2 KRT40 KRTAP10-3 KRTAP10-8 MDM2 NPM3 PAWR PAX2 PRKACA TAOK1 TP53 TP63 TP73 U2AF2 UBE2I WTAP WTIP ZNF205	2 interactors: CD2AP WT1
Entrez ID		7490	126374
HPRD ID		06163	19007
Ensembl ID		ENSG00000184937
Uniprot IDs		P19544 Q6PI38	A6NIX2
PDB IDs		1LU6 1XF7 2G7T 2G7V 2G7W 2G7X 2JP9 2JPA 2PRT 3HPJ 3MYJ
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Biosynthetic Process Cellular Response To Radiation Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Cellular Response To Light Stimulus Regulation Of Gene Expression Regulation Of Signal Transduction Gene Expression Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Apoptotic Process Regulation Of Cell Proliferation Response To Gamma Radiation Response To Abiotic Stimulus Regulation Of Signaling Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of Cell Death DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator RNA Metabolic Process DNA Damage Checkpoint Cellular Response To UV DNA Damage Response, Signal Transduction Resulting In Transcription Mitotic G1 DNA Damage Checkpoint Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Transcription, DNA-templated DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Nucleic Acid-templated Transcription Apoptotic Process Regulation Of RNA Biosynthetic Process Negative Regulation Of Cell Death Programmed Cell Death Signal Transduction In Response To DNA Damage Cell Death Death Mitotic DNA Damage Checkpoint	Negative Regulation Of Metanephric Glomerular Mesangial Cell Proliferation Positive Regulation Of Metanephric Ureteric Bud Development Thorax And Anterior Abdomen Determination Visceral Serous Pericardium Development Posterior Mesonephric Tubule Development Adrenal Cortex Formation Negative Regulation Of Glomerulus Development Negative Regulation Of Transforming Growth Factor Beta1 Production Negative Regulation Of Glomerular Mesangial Cell Proliferation Zygotic Determination Of Anterior/posterior Axis, Embryo Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Metanephros Development Negative Regulation Of Cell Proliferation Involved In Kidney Development Negative Regulation Of Transforming Growth Factor Beta Production Negative Regulation Of Female Gonad Development Cardiac Muscle Cell Fate Commitment Metanephric S-shaped Body Morphogenesis Regulation Of Glomerular Mesangial Cell Proliferation S-shaped Body Morphogenesis Negative Regulation Of Mesenchymal Cell Apoptotic Process Diaphragm Development Substrate-dependent Cell Migration, Cell Extension Positive Regulation Of Male Gonad Development Regulation Of Female Gonad Development Seminiferous Tubule Development Glomerular Basement Membrane Development Glomerular Visceral Epithelial Cell Differentiation Muscle Cell Fate Commitment Cell Motility Mesenchymal To Epithelial Transition Metanephric Mesenchyme Development Sertoli Cell Development Anterior/posterior Axis Specification, Embryo Sex Determination Cellular Response To Gonadotropin Stimulus Metanephric Nephron Morphogenesis Sertoli Cell Differentiation Male Genitalia Development Metanephric Epithelium Development Pericardium Development Metanephros Morphogenesis Locomotion Substrate-dependent Cell Migration Positive Regulation Of Kidney Development Positive Regulation Of Heart Growth Regulation Of Actin Cytoskeleton Reorganization Adrenal Gland Development Cell Differentiation Involved In Kidney Development Metanephric Nephron Development Response To Gonadotropin Movement Of Cell Or Subcellular Component
Tagcloud ?		al antisense discovery enhance et evidence genomic humans igf2r imprinted imprinting issue locus might moorwood murine particularly recent regulating relate rna since suppressor transcript transcripts tumour typically unusual wilms	ajuba coactivator conserved contributed damaged drosophila hippo homolog imply jnk jub jun lats lats1 lim limd1 link mammalian neighboring neoplastic promoted regeneration replace trigger wing wounding yap yki yorkie
Tagcloud (Difference) ?		al antisense discovery enhance et evidence genomic humans igf2r imprinted imprinting issue locus might moorwood murine particularly recent regulating relate rna since suppressor transcript transcripts tumour typically unusual wilms	ajuba coactivator conserved contributed damaged drosophila hippo homolog imply jnk jub jun lats lats1 lim limd1 link mammalian neighboring neoplastic promoted regeneration replace trigger wing wounding yap yki yorkie
Tagcloud (Intersection) ?