WT1 and CIAO1

Number of citations of the paper that reports this interaction (PMID 9556563)
11

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		WT1	CIAO1
Gene Name		Wilms tumor 1	cytosolic iron-sulfur assembly component 1
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Nuclear Speck	MMXD Complex CIA Complex
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity RNA Binding Protein Binding Zinc Ion Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding C2H2 Zinc Finger Domain Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Vasculogenesis Ureteric Bud Development Branching Involved In Ureteric Bud Morphogenesis Kidney Development Regulation Of Organ Formation Transcription, DNA-templated Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Germ Cell Development Thorax And Anterior Abdomen Determination Heart Development Sex Determination Negative Regulation Of Cell Proliferation RNA Splicing Gonad Development Male Gonad Development Tissue Development Negative Regulation Of Translation Negative Regulation Of Cell Growth Adrenal Gland Development Male Genitalia Development Epithelial Cell Differentiation Glomerulus Development Glomerular Basement Membrane Development Adrenal Cortex Formation Camera-type Eye Development Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Mesenchymal To Epithelial Transition Positive Regulation Of Heart Growth Diaphragm Development Cardiac Muscle Cell Fate Commitment Visceral Serous Pericardium Development Cellular Response To CAMP Cellular Response To Gonadotropin Stimulus Metanephric Mesenchyme Development Glomerular Visceral Epithelial Cell Differentiation Posterior Mesonephric Tubule Development Metanephric Epithelium Development Metanephric S-shaped Body Morphogenesis Negative Regulation Of Metanephric Glomerular Mesangial Cell Proliferation Positive Regulation Of Male Gonad Development Negative Regulation Of Female Gonad Development Positive Regulation Of Metanephric Ureteric Bud Development	Regulation Of Transcription From RNA Polymerase II Promoter Chromosome Segregation Positive Regulation Of Cell Proliferation Iron-sulfur Cluster Assembly Small Molecule Metabolic Process
Pathways			Cytosolic iron-sulfur cluster assembly
Drugs
Diseases
GWAS		Tuberculosis ( 22306650)
Protein-Protein Interactions		23 interactors: AREG CIAO1 CREBBP DVL3 EGR1 FHL2 KRT40 KRTAP10-3 KRTAP10-8 MDM2 NPM3 PAWR PAX2 PRKACA TAOK1 TP53 TP63 TP73 U2AF2 UBE2I WTAP WTIP ZNF205	8 interactors: APP FAM96A FAM96B GOLM1 MEOX1 SF1 SRPK1 WT1
Entrez ID		7490	9391
HPRD ID		06163	16057
Ensembl ID		ENSG00000184937
Uniprot IDs		P19544 Q6PI38	O76071
PDB IDs		1LU6 1XF7 2G7T 2G7V 2G7W 2G7X 2JP9 2JPA 2PRT 3HPJ 3MYJ	3FM0
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Biosynthetic Process Cellular Response To Radiation Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Cellular Response To Light Stimulus Regulation Of Gene Expression Regulation Of Signal Transduction Gene Expression Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Apoptotic Process Regulation Of Cell Proliferation Response To Gamma Radiation Response To Abiotic Stimulus Regulation Of Signaling Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of Cell Death DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator RNA Metabolic Process DNA Damage Checkpoint Cellular Response To UV DNA Damage Response, Signal Transduction Resulting In Transcription Mitotic G1 DNA Damage Checkpoint Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Transcription, DNA-templated DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Nucleic Acid-templated Transcription Apoptotic Process Regulation Of RNA Biosynthetic Process Negative Regulation Of Cell Death Programmed Cell Death Signal Transduction In Response To DNA Damage Cell Death Death Mitotic DNA Damage Checkpoint	Negative Regulation Of Female Gonad Development Positive Regulation Of Male Gonad Development Regulation Of Female Gonad Development RNA Processing Sex Determination Iron-sulfur Cluster Assembly Chromosome Segregation Adrenal Gland Development RNA Splicing Positive Regulation Of Transcription From RNA Polymerase II Promoter Reproduction MRNA Processing Negative Regulation Of Metanephric Glomerular Mesangial Cell Proliferation Embryonic Pattern Specification Reproductive Process Positive Regulation Of Transcription, DNA-templated MRNA Metabolic Process Positive Regulation Of Metanephric Ureteric Bud Development Thorax And Anterior Abdomen Determination Visceral Serous Pericardium Development Synaptic Growth At Neuromuscular Junction Posterior Mesonephric Tubule Development Adrenal Cortex Formation Segmentation Nucleus Organization Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Negative Regulation Of Glomerulus Development Collateral Sprouting In Absence Of Injury Negative Regulation Of Glomerular Mesangial Cell Proliferation Male Gonad Development Positive Regulation Of Cellular Biosynthetic Process Primary Sex Determination Zygotic Determination Of Anterior/posterior Axis, Embryo Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Metanephros Development Sclerotome Development Developmental Process Involved In Reproduction Collateral Sprouting Axon Midline Choice Point Recognition MRNA 3'-splice Site Recognition Negative Regulation Of Cell Proliferation Involved In Kidney Development Male Sex Differentiation RNA Metabolic Process Sexual Reproduction Regulation Of Transcription From RNA Polymerase II Promoter Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Somite Specification Cardiac Muscle Cell Fate Commitment Intracellular Receptor Signaling Pathway Multicellular Organismal Reproductive Process
Tagcloud ?		al antisense discovery enhance et evidence genomic humans igf2r imprinted imprinting issue locus might moorwood murine particularly recent regulating relate rna since suppressor transcript transcripts tumour typically unusual wilms
Tagcloud (Difference) ?		al antisense discovery enhance et evidence genomic humans igf2r imprinted imprinting issue locus might moorwood murine particularly recent regulating relate rna since suppressor transcript transcripts tumour typically unusual wilms
Tagcloud (Intersection) ?