WT1 and DIRAS3

Number of citations: 0 (PubMedID 25640309)
Data Source: BioGRID (two hybrid)

		WT1	DIRAS3
Name		WT1 transcription factor	DIRAS family GTPase 3
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Nuclear Speck	Plasma Membrane Membrane
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity RNA Binding Protein Binding Zinc Ion Binding Double-stranded Methylated DNA Binding Sequence-specific DNA Binding Hemi-methylated DNA-binding Metal Ion Binding C2H2 Zinc Finger Domain Binding Sequence-specific Double-stranded DNA Binding	Nucleotide Binding GTPase Activity Protein Binding GTP Binding GDP Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Vasculogenesis Ureteric Bud Development Branching Involved In Ureteric Bud Morphogenesis Kidney Development Regulation Of Animal Organ Formation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Germ Cell Development Thorax And Anterior Abdomen Determination Heart Development Sex Determination Negative Regulation Of Cell Population Proliferation RNA Splicing Gonad Development Male Gonad Development Tissue Development Positive Regulation Of Gene Expression Negative Regulation Of Translation Negative Regulation Of Cell Growth Adrenal Gland Development Male Genitalia Development Epithelial Cell Differentiation Glomerulus Development Glomerular Basement Membrane Development Adrenal Cortex Formation Camera-type Eye Development Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Mesenchymal To Epithelial Transition Positive Regulation Of Heart Growth Diaphragm Development Cardiac Muscle Cell Fate Commitment Visceral Serous Pericardium Development Cellular Response To CAMP Cellular Response To Gonadotropin Stimulus Metanephric Mesenchyme Development Nephron Tubule Morphogenesis Podocyte Differentiation Posterior Mesonephric Tubule Development Metanephric Epithelium Development Metanephric S-shaped Body Morphogenesis Negative Regulation Of Metanephric Glomerular Mesangial Cell Proliferation Circulatory System Development Positive Regulation Of MiRNA Transcription Positive Regulation Of Male Gonad Development Negative Regulation Of Female Gonad Development Positive Regulation Of Metanephric Ureteric Bud Development	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Signal Transduction Small GTPase-mediated Signal Transduction Genomic Imprinting
Pathways		Transcriptional regulation of testis differentiation Negative Regulation of CDH1 Gene Transcription Nephron development	None
Diseases		Nephrotic syndrome and focal segmental glomerulosclerosis 46,XY disorders of sex development (Disorders of gonadal development), including: Gonadal agenesis; Complete and partial gonadal dysgenesis; Testis regression; Ovotesticular DSD	None
GWAS		Apolipoprotein A1 levels ( 32203549 ) Birth weight ( 31043758 ) Brugada syndrome ( 35210625 ) Coronary artery disease ( 33020668 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Endometrial cancer ( 30093612 ) Endometrial cancer (endometrioid histology) ( 30093612 ) Inguinal hernia ( 26686553 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Medication use (diuretics) ( 31015401 ) Offspring birth weight ( 31043758 ) Pelvic organ prolapse ( 32184442 ) PR interval ( 32439900 ) Pulse pressure ( 30224653 ) Resting-state electroencephalogram vigilance ( 29703947 ) Rubella-specific interleukin-6 secretion ( 29253144 ) Tuberculosis ( 24057671 22306650 ) Uterine fibroids ( 31649266 31249589 30194396 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )	No GWAS studies recorded
Novel Interactors		8 novel interactors: B3GNT3 BST2 CALML5 CAPRIN1 FJX1 HIPK3 PAX6 PEX3	2 novel interactors: ACADM HTR2A
Interacting Genes		66 interacting genes: AREG BHLHE40 CASZ1 CCDC136 CCDC33 CCL5 CEP70 CIAO1 CREBBP CYSRT1 DIRAS3 DVL2 DVL3 EGR1 ETV7 FAM9B FHL2 FMR1NB GLIS2 GOLGA2 HMBOX1 IDI1 IPO8 KLK7 KPNA4 KPNA5 KRT40 KRTAP10-1 KRTAP10-3 KRTAP10-4 KRTAP10-5 KRTAP10-6 KRTAP10-7 KRTAP10-8 KRTAP10-9 LDOC1 MAGEA8 MDM2 MYC NAT2 NPM3 OGT OSBPL3 PAWR PAX2 PICK1 PRKACA RNASEH2B SERF2 SOX4 STK11 TAOK1 THAP1 THRSP TP53 TP63 TP73 TRIM55 TRIM63 U2AF2 UBE2I WTAP WTIP YAP1 ZNF205 ZRANB1	12 interacting genes: APC BAG4 BRMS1 CHEK2 FGFR4 KRAS MEOX2 PALB2 PPM1D PTPN1 TGFB1 WT1
Entrez ID		7490	9077
HPRD ID		06163	05547
Ensembl ID		ENSG00000184937	ENSG00000162595
Uniprot IDs		A0A481V744 H0Y7K5 P19544 Q6PI38	O95661
PDB IDs		1XF7 2JP9 2JPA 2PRT 3HPJ 3MYJ 4R2E 4R2P 4R2Q 4R2R 4R2S 4WUU 5KL2 5KL3 5KL4 5KL5 5KL6 5KL7 6B0O 6B0P 6B0Q 6B0R 6BLW 6RSY 6WLH 7BBG 8ISN	6NAZ
GO Terms Enriched among Interactors		Keratin Filament Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Intermediate Filament Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process P53 Binding Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Macromolecule Metabolic Process Transcription Cis-regulatory Region Binding Nuclear Body Nucleoplasm Regulation Of Transcription By RNA Polymerase II Cellular Response To Gamma Radiation Cellular Response To Radiation Chromatin Identical Protein Binding Epithelial Cell Proliferation Regulation Of Stem Cell Population Maintenance Regulation Of Somatic Stem Cell Population Maintenance MDM2/MDM4 Family Protein Binding Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Signal Transduction Cellular Response To UV Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Cellular Response To Actinomycin D Cell Population Proliferation Positive Regulation Of Lymphocyte Apoptotic Process Nucleus Regulation Of Intracellular Signal Transduction Regulation Of Gene Expression Signal Transduction By P53 Class Mediator Response To Gamma Radiation Transcription Factor Binding Regulation Of Metabolic Process Regulation Of Signal Transduction DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of MiRNA Transcription Cytosol Cellular Response To Light Stimulus Response To Actinomycin D PML Body	Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Apoptotic Process Protein-containing Complex Binding Regulation Of Primary Metabolic Process Regulation Of Metabolic Process Regulation Of Signal Transduction Regulation Of Cell Population Proliferation Positive Regulation Of Anoikis Positive Regulation Of Macromolecule Metabolic Process Response To Nutrient Levels Positive Regulation Of Metabolic Process Regulation Of Cell Communication Regulation Of Macromolecule Metabolic Process Regulation Of Signaling Regulation Of Intracellular Signal Transduction Gland Development Regulation Of Cell Migration Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Fibroblast Migration Liver Development Regulation Of Protein Metabolic Process Regulation Of Cell Motility Regulation Of Locomotion Negative Regulation Of Cell Migration Negative Regulation Of Cell Motility Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Intracellular Signal Transduction Branching Morphogenesis Of An Epithelial Tube Positive Regulation Of Endothelial Cell Apoptotic Process Negative Regulation Of Locomotion Regulation Of Extracellular Matrix Disassembly Negative Regulation Of Cell Population Proliferation Regulation Of Anoikis Morphogenesis Of A Branching Epithelium Pattern Specification Process Tissue Morphogenesis Morphogenesis Of A Branching Structure Negative Regulation Of Protein Serine/threonine Kinase Activity Response To Radiation Phosphate-containing Compound Metabolic Process Positive Regulation Of MAPK Cascade Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Apoptotic Process Regulation Of Kidney Development Apoptotic Process Regulation Of Fibroblast Migration Ureteric Bud Development Negative Regulation Of Programmed Cell Death