WT1 and BST2

Data Source: HiPPIP (Novel)

		WT1	BST2
Name		WT1 transcription factor	bone marrow stromal cell antigen 2
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Nuclear Speck	Cytoplasm Endosome Late Endosome Multivesicular Body Golgi Apparatus Plasma Membrane Cell Surface Membrane Apical Plasma Membrane Azurophil Granule Membrane Membrane Raft Extracellular Exosome Side Of Membrane
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity RNA Binding Protein Binding Zinc Ion Binding Double-stranded Methylated DNA Binding Sequence-specific DNA Binding Hemi-methylated DNA-binding Metal Ion Binding C2H2 Zinc Finger Domain Binding Sequence-specific Double-stranded DNA Binding	RNA Binding Protein Binding Metalloendopeptidase Inhibitor Activity Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Vasculogenesis Ureteric Bud Development Branching Involved In Ureteric Bud Morphogenesis Kidney Development Regulation Of Animal Organ Formation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Germ Cell Development Thorax And Anterior Abdomen Determination Heart Development Sex Determination Negative Regulation Of Cell Population Proliferation RNA Splicing Gonad Development Male Gonad Development Tissue Development Positive Regulation Of Gene Expression Negative Regulation Of Translation Negative Regulation Of Cell Growth Adrenal Gland Development Male Genitalia Development Epithelial Cell Differentiation Glomerulus Development Glomerular Basement Membrane Development Adrenal Cortex Formation Camera-type Eye Development Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Mesenchymal To Epithelial Transition Positive Regulation Of Heart Growth Diaphragm Development Cardiac Muscle Cell Fate Commitment Visceral Serous Pericardium Development Cellular Response To CAMP Cellular Response To Gonadotropin Stimulus Metanephric Mesenchyme Development Nephron Tubule Morphogenesis Podocyte Differentiation Posterior Mesonephric Tubule Development Metanephric Epithelium Development Metanephric S-shaped Body Morphogenesis Negative Regulation Of Metanephric Glomerular Mesangial Cell Proliferation Circulatory System Development Positive Regulation Of MiRNA Transcription Positive Regulation Of Male Gonad Development Negative Regulation Of Female Gonad Development Positive Regulation Of Metanephric Ureteric Bud Development	Immune System Process Negative Regulation Of Plasmacytoid Dendritic Cell Cytokine Production Response To Virus Negative Regulation Of Cell Growth Negative Regulation Of Cell Migration Regulation Of Actin Cytoskeleton Organization Response To Type II Interferon Response To Interferon-alpha Response To Interferon-beta B Cell Activation Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Viral Genome Replication Innate Immune Response Defense Response To Virus Positive Regulation Of Leukocyte Proliferation Negative Regulation Of Intracellular Transport Of Viral Material
Pathways		Transcriptional regulation of testis differentiation Negative Regulation of CDH1 Gene Transcription Nephron development	Neutrophil degranulation Interferon alpha/beta signaling SARS-CoV-1 activates/modulates innate immune responses
Diseases		Nephrotic syndrome and focal segmental glomerulosclerosis 46,XY disorders of sex development (Disorders of gonadal development), including: Gonadal agenesis; Complete and partial gonadal dysgenesis; Testis regression; Ovotesticular DSD	None
GWAS		Apolipoprotein A1 levels ( 32203549 ) Birth weight ( 31043758 ) Brugada syndrome ( 35210625 ) Coronary artery disease ( 33020668 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Endometrial cancer ( 30093612 ) Endometrial cancer (endometrioid histology) ( 30093612 ) Inguinal hernia ( 26686553 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Medication use (diuretics) ( 31015401 ) Offspring birth weight ( 31043758 ) Pelvic organ prolapse ( 32184442 ) PR interval ( 32439900 ) Pulse pressure ( 30224653 ) Resting-state electroencephalogram vigilance ( 29703947 ) Rubella-specific interleukin-6 secretion ( 29253144 ) Tuberculosis ( 24057671 22306650 ) Uterine fibroids ( 31649266 31249589 30194396 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )	No GWAS studies recorded
Novel Interactors		8 novel interactors: B3GNT3 BST2 CALML5 CAPRIN1 FJX1 HIPK3 PAX6 PEX3	2 novel interactors: GATAD2A WT1
Interacting Genes		66 interacting genes: AREG BHLHE40 CASZ1 CCDC136 CCDC33 CCL5 CEP70 CIAO1 CREBBP CYSRT1 DIRAS3 DVL2 DVL3 EGR1 ETV7 FAM9B FHL2 FMR1NB GLIS2 GOLGA2 HMBOX1 IDI1 IPO8 KLK7 KPNA4 KPNA5 KRT40 KRTAP10-1 KRTAP10-3 KRTAP10-4 KRTAP10-5 KRTAP10-6 KRTAP10-7 KRTAP10-8 KRTAP10-9 LDOC1 MAGEA8 MDM2 MYC NAT2 NPM3 OGT OSBPL3 PAWR PAX2 PICK1 PRKACA RNASEH2B SERF2 SOX4 STK11 TAOK1 THAP1 THRSP TP53 TP63 TP73 TRIM55 TRIM63 U2AF2 UBE2I WTAP WTIP YAP1 ZNF205 ZRANB1	3 interacting genes: CD81 HAGH HARS2
Entrez ID		7490	684
HPRD ID		06163	02759
Ensembl ID		ENSG00000184937	ENSG00000130303
Uniprot IDs		A0A481V744 H0Y7K5 P19544 Q6PI38	A0A024R7H5 Q10589
PDB IDs		1XF7 2JP9 2JPA 2PRT 3HPJ 3MYJ 4R2E 4R2P 4R2Q 4R2R 4R2S 4WUU 5KL2 5KL3 5KL4 5KL5 5KL6 5KL7 6B0O 6B0P 6B0Q 6B0R 6BLW 6RSY 6WLH 7BBG 8ISN	2LK9 2X7A 2XG7 3MQ7 3MQ9 3MQB 3MQC 3NWH 4P6Z 6CM9 6CRI 6D83 6D84 6DFF 7Q9A
GO Terms Enriched among Interactors		Keratin Filament Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Intermediate Filament Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process P53 Binding Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Macromolecule Metabolic Process Transcription Cis-regulatory Region Binding Nuclear Body Nucleoplasm Regulation Of Transcription By RNA Polymerase II Cellular Response To Gamma Radiation Cellular Response To Radiation Chromatin Identical Protein Binding Epithelial Cell Proliferation Regulation Of Stem Cell Population Maintenance Regulation Of Somatic Stem Cell Population Maintenance MDM2/MDM4 Family Protein Binding Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Signal Transduction Cellular Response To UV Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Cellular Response To Actinomycin D Cell Population Proliferation Positive Regulation Of Lymphocyte Apoptotic Process Nucleus Regulation Of Intracellular Signal Transduction Regulation Of Gene Expression Signal Transduction By P53 Class Mediator Response To Gamma Radiation Transcription Factor Binding Regulation Of Metabolic Process Regulation Of Signal Transduction DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of MiRNA Transcription Cytosol Cellular Response To Light Stimulus Response To Actinomycin D PML Body	Positive Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Macrophage Fusion Positive Regulation Of Adaptive Immune Memory Response CD4-positive, Alpha-beta T Cell Costimulation Myoblast Fusion Involved In Skeletal Muscle Regeneration Hydroxyacylglutathione Hydrolase Activity Methylglyoxal Catabolic Process To D-lactate Via S-lactoyl-glutathione Negative Regulation Of Female Gonad Development Negative Regulation Of Metanephric Glomerular Mesangial Cell Proliferation Negative Regulation Of Glomerular Mesangial Cell Proliferation Adrenal Cortex Formation Positive Regulation Of Metanephric Ureteric Bud Development Visceral Serous Pericardium Development Posterior Mesonephric Tubule Development Histidine-tRNA Ligase Activity Histidyl-tRNA Aminoacylation Methylglyoxal Catabolic Process To Lactate Cellular Detoxification Of Methylglyoxal Hemi-methylated DNA-binding Metanephric S-shaped Body Morphogenesis MHC Class II Protein Binding Humoral Immune Response Mediated By Circulating Immunoglobulin Osteoclast Fusion Methylglyoxal Metabolic Process Negative Regulation Of Cell Proliferation Involved In Kidney Development Thorax And Anterior Abdomen Determination S-shaped Body Morphogenesis Double-stranded Methylated DNA Binding Positive Regulation Of B Cell Receptor Signaling Pathway Positive Regulation Of Protein Catabolic Process In The Vacuole Diaphragm Development Regulation Of Female Gonad Development Positive Regulation Of Male Gonad Development Cardiac Muscle Cell Fate Commitment Metanephric Mesenchyme Development Positive Regulation Of T-helper 2 Cell Cytokine Production Tetraspanin-enriched Microdomain Positive Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Positive Regulation Of Protein Exit From Endoplasmic Reticulum Transferrin Receptor Binding Immunological Synapse Formation Positive Regulation Of Receptor Clustering Positive Regulation Of Inflammatory Response To Antigenic Stimulus Glutathione Biosynthetic Process Aldehyde Catabolic Process Cellular Detoxification Of Aldehyde Metanephric Epithelium Development Muscle Cell Fate Commitment Nephron Tubule Morphogenesis Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation