TRAF6 and HNRNPA1

Number of citations of the paper that reports this interaction (PubMedID 28024152)
53

Data Source:
BioGRID (enzymatic study)

		TRAF6	HNRNPA1
Description		TNF receptor associated factor 6	heterogeneous nuclear ribonucleoprotein A1
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Lipid Droplet Cytosol Plasma Membrane Cell Cortex Cytoplasmic Side Of Plasma Membrane Endosome Membrane Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Protein-containing Complex CD40 Receptor Complex Perinuclear Region Of Cytoplasm Glutamatergic Synapse	Nucleus Nucleoplasm Spliceosomal Complex Cytoplasm Cytosol Membrane Synapse Extracellular Exosome Catalytic Step 2 Spliceosome Ribonucleoprotein Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Tumor Necrosis Factor Receptor Binding Protein Binding Zinc Ion Binding Transferase Activity Enzyme Binding Protein-macromolecule Adaptor Activity Ubiquitin Conjugating Enzyme Binding Ubiquitin-ubiquitin Ligase Activity Signaling Adaptor Activity Identical Protein Binding Histone Deacetylase Binding Protein Kinase B Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Nucleic Acid Binding DNA Binding Single-stranded DNA Binding RNA Binding Single-stranded RNA Binding MRNA 3'-UTR Binding Protein Binding Protein Domain Specific Binding MiRNA Binding Pre-mRNA Binding Identical Protein Binding Telomeric Repeat-containing RNA Binding G-rich Strand Telomeric DNA Binding
	Biological Process	Autophagosome Assembly Negative Regulation Of Transcription By RNA Polymerase II Protein Polyubiquitination Ossification In Utero Embryonic Development Neural Tube Closure Stimulatory C-type Lectin Receptor Signaling Pathway Immune System Process Regulation Of Immunoglobulin Production Positive Regulation Of T Cell Cytokine Production Cytoplasmic Pattern Recognition Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Immune Response DNA Damage Response Signal Transduction Canonical NF-kappaB Signal Transduction MRNA Transcription Animal Organ Morphogenesis Protein Ubiquitination Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II CD40 Signaling Pathway Osteoclast Differentiation Positive Regulation Of Protein Ubiquitination Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Activation Of Protein Kinase Activity Positive Regulation Of Type I Interferon Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-6 Production Tumor Necrosis Factor-mediated Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Non-canonical NF-kappaB Signal Transduction Fc-epsilon Receptor Signaling Pathway Interleukin-33-mediated Signaling Pathway Interleukin-17A-mediated Signaling Pathway T-helper 1 Type Immune Response Positive Regulation Of T Cell Proliferation Odontogenesis Of Dentin-containing Tooth Defense Response To Bacterium Regulation Of Apoptotic Process Myeloid Dendritic Cell Differentiation Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of JUN Kinase Activity Innate Immune Response Bone Resorption Positive Regulation Of Osteoclast Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Bone Remodeling Cell Development T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Autoubiquitination Interleukin-1-mediated Signaling Pathway Protein K63-linked Ubiquitination Response To Interleukin-1 Protein K48-linked Ubiquitination Cellular Response To Lipopolysaccharide Cellular Response To Cytokine Stimulus Interleukin-17-mediated Signaling Pathway Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Antiviral Innate Immune Response Intracellular Signaling Cassette Protein Branched Polyubiquitination Cellular Response To Oxygen-containing Compound Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell	Alternative MRNA Splicing, Via Spliceosome Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome MRNA Processing RNA Export From Nucleus RNA Splicing Negative Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Telomere Maintenance Via Telomerase Cellular Response To Glucose Starvation Regulation Of RNA Splicing MRNA Transport Nuclear Export Import Into Nucleus Cellular Response To Sodium Arsenite
Pathways		PIP3 activates AKT signaling MyD88:MAL(TIRAP) cascade initiated on plasma membrane NOD1/2 Signaling Pathway TICAM1, RIP1-mediated IKK complex recruitment Regulated proteolysis of p75NTR Downstream TCR signaling NRIF signals cell death from the nucleus NRIF signals cell death from the nucleus p75NTR recruits signalling complexes NF-kB is activated and signals survival FCERI mediated NF-kB activation TAK1-dependent IKK and NF-kappa-B activation activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 CLEC7A (Dectin-1) signaling Ub-specific processing proteases Ovarian tumor domain proteases PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling TICAM1,TRAF6-dependent induction of TAK1 complex Interleukin-1 signaling TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation TRAF6 mediated NF-kB activation IRAK1 recruits IKK complex IKK complex recruitment mediated by RIP1 IRAK2 mediated activation of TAK1 complex TRAF6-mediated induction of TAK1 complex within TLR4 complex Alpha-protein kinase 1 signaling pathway SARS-CoV-1 activates/modulates innate immune responses SARS-CoV-2 activates/modulates innate and adaptive immune responses TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation MyD88 dependent cascade initiated on endosome IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation Regulation of NF-kappa B signaling MyD88 cascade initiated on plasma membrane	FGFR2 alternative splicing mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA SARS-CoV-1-host interactions SARS-CoV-1 modulates host translation machinery
Drugs
Diseases
GWAS		Idiopathic inflammatory myopathy ( 26362759) Metabolite levels ( 23823483) Rheumatoid arthritis ( 24390342 30423114)	Meat-related diet ( 32066663) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		184 interacting genes: ABL1 AKT1 APP ATM ATP6V1E1 ATXN3 BANK1 BCL3 BEX3 BMPR1B BRSK2 CAV1 CBL CD40 CUL5 CYLD DLG4 DNA2 ECSIT EDA2R EDARADD FADD FAM177A1 FHL2 FYN GART GTF2I H2AX H2BC21 HNRNPA1 HSD17B10 HSPA4 IL17RB IPMK IQUB IRAK1 IRAK2 IRAK3 IRAK4 IRF5 IRF7 IRF8 JAK2 KCNQ1 LIMD1 LNX1 MALT1 MAP2K1 MAP2K6 MAP2K7 MAP3K11 MAP3K14 MAP3K3 MAP3K5 MAP3K7 MAP3K8 MAPK14 MAPK8 MAPT MAST2 MATR3 MAVS MBP MCL1 MEOX2 MTOR MTURN NEAT1 NGFR NOL3 NTRK1 NTRK2 NUMBL OTUB1 OTUB2 OTUD7B PEDS1-UBE2V1 PELI3 PFN1 PHLDA1 PINK1 PLEKHF2 PLEKHO1 POLI PPP4C PRKCZ PSMB5 PSMC1 PSMC2 PSMC3 PSMD1 PSMD12 PSMD13 PSMD6 PSMD7 PTPN6 RAD23A RIPK1 RIPK2 RIPK3 RNF114 RNF152 RNF31 RPL3 RPS2 RPS20 RPS27A RSAD2 SIGIRR SPHK1 SPOP SQSTM1 SRC STAMBP STK17A STK26 STRADB STUB1 SUFU SYK TAB1 TAB2 TAB3 TANK TAX1BP1 TDP2 TGFBR1 TICAM1 TICAM2 TIFA TIRAP TLR3 TNFAIP3 TNFRSF11A TNFRSF13B TNFRSF19 TNFSF11 TRAF1 TRAF2 TRAF3IP1 TRAF3IP2 TRAF4 TRAF5 TRAF7 TRAFD1 TRAM1 TRIM17 TRIM25 TRIM37 TTC3 TXNIP UBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2I UBE2L3 UBE2N UBE2V1 UBOX5 UBTD1 UBXN7 UEVLD USP1 USP15 USP2 USP21 USP39 USP7 VPS52 XIAP YBX1 YES1 YOD1 YWHAQ ZBTB25 ZDHHC11 ZFAND5 ZMYND11 ZNF675 ZRANB1	120 interacting genes: ABHD16A APP BCL2L1 CALCOCO2 CCDC50 CEBPA CLK1 DANCR ERG ESR1 FEN1 H3-4 H3C1 HIPK3 HMGA1 HNRNPH3 KHSRP MARCHF8 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I NFKBIA NR0B2 NR3C1 OGT PABPN1 PHYHIP PPIL1 PRKDC PRMT1 PRMT2 PRMT3 PRRC2A PSMD9 PTEN RNF14 RPL21 RPS6KB2 SAFB SREK1 SRPK1 SRPK2 SUFU TFEC TNPO1 TRA2B TRAF6 TSHR TTF2 XIAP XRN1
Entrez ID		7189	3178
HPRD ID		03833	01242
Ensembl ID		ENSG00000175104	ENSG00000135486
Uniprot IDs		Q9Y4K3	A0A024RB53 P09651
PDB IDs		1LB4 1LB5 1LB6 2ECI 2JMD 3HCS 3HCT 3HCU 4Z8M 5ZUJ 6A33 7L3L 8HZ2	1HA1 1L3K 1PGZ 1PO6 1U1K 1U1L 1U1M 1U1N 1U1O 1U1P 1U1Q 1U1R 1UP1 2H4M 2LYV 2UP1 4YOE 5MPG 5MPL 5ZGD 5ZGL 6BXX 6DCL 6J60 7BX7 7ZJ2 8IK7 8IKB 8IKP 8IKS 8RZV 8X0N 9F1S 9F4D 9F4G 9F4H 9F4J 9F4K 9F4L 9F4N 9F4O 9F4P 9F4Q 9F4R 9F4S 9F4T 9F4U 9F4V 9F4W 9F4X 9F4Y 9F4Z 9F50 9F51 9F52 9F53 9F54 9F55 9F5C 9F5D 9F5E 9F5F 9F5G 9F5K 9F7F 9F7H 9GEA 9GPJ 9HQ9 9HQJ 9HQL
Enriched GO Terms of Interacting Partners?		Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Protein Modification Process Protein Metabolic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Signal Transduction Intracellular Signal Transduction Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Post-translational Protein Modification Regulation Of Signaling Regulation Of Cell Communication Innate Immune Response-activating Signaling Pathway Positive Regulation Of Defense Response Pattern Recognition Receptor Signaling Pathway Activation Of Innate Immune Response Response To Stress Immune Response-regulating Signaling Pathway Regulation Of Defense Response Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Innate Immune Response Immune Response-activating Signaling Pathway Cell Surface Receptor Signaling Pathway Signal Transduction Proteolysis Cytosol Activation Of Immune Response Ubiquitin-dependent Protein Catabolic Process Ubiquitin Protein Ligase Binding Protein Polyubiquitination Positive Regulation Of Immune Response Regulation Of Innate Immune Response Macromolecule Metabolic Process Regulation Of Immune Response Defense Response Protein Kinase Activity MAPK Cascade Cytoplasmic Pattern Recognition Receptor Signaling Pathway Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Transferase Activity Negative Regulation Of Signal Transduction Regulation Of Cytokine-mediated Signaling Pathway Protein Ubiquitination Positive Regulation Of Protein Metabolic Process Positive Regulation Of Immune System Process Negative Regulation Of Signaling	MiRNA-mediated Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Regulatory NcRNA-mediated Gene Silencing Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Extracellular Vesicle Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Translation Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process MRNA Destabilization RNA Destabilization Positive Regulation Of MRNA Catabolic Process Positive Regulation Of MRNA Metabolic Process Regulation Of Translation Negative Regulation Of Cell Migration Negative Regulation Of Cytokine Production Negative Regulation Of Cell Motility Negative Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Locomotion Negative Regulation Of Protein Metabolic Process Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Negative Regulation Of Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Angiogenesis Regulation Of Vasculature Development Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Developmental Process Regulation Of MRNA Stability Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of MRNA Metabolic Process Regulation Of RNA Stability Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Endothelial Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Blood Vessel Endothelial Cell Migration
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