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TRAF6 and UBE2D2
Number of citations of the paper that reports this interaction (PubMedID
32296183
)
50
Data Source:
BioGRID
(two hybrid)
TRAF6
UBE2D2
Description
TNF receptor associated factor 6
ubiquitin conjugating enzyme E2 D2
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Lipid Droplet
Cytosol
Plasma Membrane
Cell Cortex
Cytoplasmic Side Of Plasma Membrane
Endosome Membrane
Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
Protein-containing Complex
CD40 Receptor Complex
Perinuclear Region Of Cytoplasm
Glutamatergic Synapse
Nucleus
Nucleoplasm
Cytosol
Protein-containing Complex
Extracellular Exosome
Molecular Function
Ubiquitin-protein Transferase Activity
Tumor Necrosis Factor Receptor Binding
Protein Binding
Zinc Ion Binding
Transferase Activity
Enzyme Binding
Protein-macromolecule Adaptor Activity
Ubiquitin Conjugating Enzyme Binding
Ubiquitin-ubiquitin Ligase Activity
Signaling Adaptor Activity
Identical Protein Binding
Histone Deacetylase Binding
Protein Kinase B Binding
Metal Ion Binding
Ubiquitin Protein Ligase Activity
Nucleotide Binding
Ubiquitin-protein Transferase Activity
Protein Binding
ATP Binding
Transferase Activity
Ubiquitin Protein Ligase Activity
Ubiquitin Conjugating Enzyme Activity
Biological Process
Autophagosome Assembly
Negative Regulation Of Transcription By RNA Polymerase II
Protein Polyubiquitination
Ossification
In Utero Embryonic Development
Neural Tube Closure
Stimulatory C-type Lectin Receptor Signaling Pathway
Immune System Process
Regulation Of Immunoglobulin Production
Positive Regulation Of T Cell Cytokine Production
Cytoplasmic Pattern Recognition Receptor Signaling Pathway
MyD88-dependent Toll-like Receptor Signaling Pathway
Immune Response
DNA Damage Response
Signal Transduction
Canonical NF-kappaB Signal Transduction
MRNA Transcription
Animal Organ Morphogenesis
Protein Ubiquitination
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II
CD40 Signaling Pathway
Osteoclast Differentiation
Positive Regulation Of Protein Ubiquitination
Lipopolysaccharide-mediated Signaling Pathway
Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway
Activation Of Protein Kinase Activity
Positive Regulation Of Type I Interferon Production
Positive Regulation Of Interleukin-12 Production
Positive Regulation Of Interleukin-2 Production
Positive Regulation Of Interleukin-6 Production
Tumor Necrosis Factor-mediated Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
TRIF-dependent Toll-like Receptor Signaling Pathway
Non-canonical NF-kappaB Signal Transduction
Fc-epsilon Receptor Signaling Pathway
Interleukin-33-mediated Signaling Pathway
Interleukin-17A-mediated Signaling Pathway
T-helper 1 Type Immune Response
Positive Regulation Of T Cell Proliferation
Odontogenesis Of Dentin-containing Tooth
Defense Response To Bacterium
Regulation Of Apoptotic Process
Myeloid Dendritic Cell Differentiation
Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Negative Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of JUN Kinase Activity
Innate Immune Response
Bone Resorption
Positive Regulation Of Osteoclast Differentiation
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of JNK Cascade
Bone Remodeling
Cell Development
T Cell Receptor Signaling Pathway
Positive Regulation Of NF-kappaB Transcription Factor Activity
Protein Autoubiquitination
Interleukin-1-mediated Signaling Pathway
Protein K63-linked Ubiquitination
Response To Interleukin-1
Protein K48-linked Ubiquitination
Cellular Response To Lipopolysaccharide
Cellular Response To Cytokine Stimulus
Interleukin-17-mediated Signaling Pathway
Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane
Antiviral Innate Immune Response
Intracellular Signaling Cassette
Protein Branched Polyubiquitination
Cellular Response To Oxygen-containing Compound
Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell
Protein Polyubiquitination
Ubiquitin-dependent Protein Catabolic Process
Protein Ubiquitination
Protein Modification Process
Protein Autoubiquitination
Protein K48-linked Ubiquitination
Pathways
PIP3 activates AKT signaling
MyD88:MAL(TIRAP) cascade initiated on plasma membrane
NOD1/2 Signaling Pathway
TICAM1, RIP1-mediated IKK complex recruitment
Regulated proteolysis of p75NTR
Downstream TCR signaling
NRIF signals cell death from the nucleus
NRIF signals cell death from the nucleus
p75NTR recruits signalling complexes
NF-kB is activated and signals survival
FCERI mediated NF-kB activation
TAK1-dependent IKK and NF-kappa-B activation
activated TAK1 mediates p38 MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
CLEC7A (Dectin-1) signaling
Ub-specific processing proteases
Ovarian tumor domain proteases
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
TICAM1,TRAF6-dependent induction of TAK1 complex
Interleukin-1 signaling
TRAF6 mediated IRF7 activation
TRAF6 mediated NF-kB activation
TRAF6 mediated NF-kB activation
IRAK1 recruits IKK complex
IKK complex recruitment mediated by RIP1
IRAK2 mediated activation of TAK1 complex
TRAF6-mediated induction of TAK1 complex within TLR4 complex
Alpha-protein kinase 1 signaling pathway
SARS-CoV-1 activates/modulates innate immune responses
SARS-CoV-2 activates/modulates innate and adaptive immune responses
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
MyD88 dependent cascade initiated on endosome
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
Regulation of NF-kappa B signaling
MyD88 cascade initiated on plasma membrane
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
TICAM1, RIP1-mediated IKK complex recruitment
Downstream TCR signaling
FCERI mediated NF-kB activation
PINK1-PRKN Mediated Mitophagy
Regulation of TNFR1 signaling
CLEC7A (Dectin-1) signaling
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
E3 ubiquitin ligases ubiquitinate target proteins
Neddylation
Peroxisomal protein import
Negative regulators of DDX58/IFIH1 signaling
IKK complex recruitment mediated by RIP1
Inactivation of CSF3 (G-CSF) signaling
Antigen processing: Ubiquitination & Proteasome degradation
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
Drugs
(R,R)-2,3-Butanediol
Diseases
GWAS
Idiopathic inflammatory myopathy (
26362759
)
Metabolite levels (
23823483
)
Rheumatoid arthritis (
24390342
30423114
)
Alzheimer's disease (late onset) (
30820047
)
Body mass index (
26426971
)
Immune reponse to smallpox (secreted IFN-alpha) (
22610502
)
Leukocyte telomere length (
32109421
)
Interacting Genes
184 interacting genes:
ABL1
AKT1
APP
ATM
ATP6V1E1
ATXN3
BANK1
BCL3
BEX3
BMPR1B
BRSK2
CAV1
CBL
CD40
CUL5
CYLD
DLG4
DNA2
ECSIT
EDA2R
EDARADD
FADD
FAM177A1
FHL2
FYN
GART
GTF2I
H2AX
H2BC21
HNRNPA1
HSD17B10
HSPA4
IL17RB
IPMK
IQUB
IRAK1
IRAK2
IRAK3
IRAK4
IRF5
IRF7
IRF8
JAK2
KCNQ1
LIMD1
LNX1
MALT1
MAP2K1
MAP2K6
MAP2K7
MAP3K11
MAP3K14
MAP3K3
MAP3K5
MAP3K7
MAP3K8
MAPK14
MAPK8
MAPT
MAST2
MATR3
MAVS
MBP
MCL1
MEOX2
MTOR
MTURN
NEAT1
NGFR
NOL3
NTRK1
NTRK2
NUMBL
OTUB1
OTUB2
OTUD7B
PEDS1-UBE2V1
PELI3
PFN1
PHLDA1
PINK1
PLEKHF2
PLEKHO1
POLI
PPP4C
PRKCZ
PSMB5
PSMC1
PSMC2
PSMC3
PSMD1
PSMD12
PSMD13
PSMD6
PSMD7
PTPN6
RAD23A
RIPK1
RIPK2
RIPK3
RNF114
RNF152
RNF31
RPL3
RPS2
RPS20
RPS27A
RSAD2
SIGIRR
SPHK1
SPOP
SQSTM1
SRC
STAMBP
STK17A
STK26
STRADB
STUB1
SUFU
SYK
TAB1
TAB2
TAB3
TANK
TAX1BP1
TDP2
TGFBR1
TICAM1
TICAM2
TIFA
TIRAP
TLR3
TNFAIP3
TNFRSF11A
TNFRSF13B
TNFRSF19
TNFSF11
TRAF1
TRAF2
TRAF3IP1
TRAF3IP2
TRAF4
TRAF5
TRAF7
TRAFD1
TRAM1
TRIM17
TRIM25
TRIM37
TTC3
TXNIP
UBB
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E1
UBE2I
UBE2L3
UBE2N
UBE2V1
UBOX5
UBTD1
UBXN7
UEVLD
USP1
USP15
USP2
USP21
USP39
USP7
VPS52
XIAP
YBX1
YES1
YOD1
YWHAQ
ZBTB25
ZDHHC11
ZFAND5
ZMYND11
ZNF675
ZRANB1
244 interacting genes:
AMFR
ANAPC11
ANAPC2
AREL1
ARIH2
ARRDC3
BARD1
BFAR
BIRC2
BIRC3
BIRC7
BIRC8
BMI1
BRAP
BRCA1
BTRC
CADPS2
CBL
CBLB
CBLC
CCNB1
CDKN1B
CHFR
CNOT4
COP1
CUEDC1
CUL3
DCAF1
DTX1
DTX2
DTX3
DTX3L
DZIP3
EPS15
F12
FBXL3
FBXO2
FBXO4
FBXO7
FBXW2
HACE1
HECTD1
HECTD3
HECTD4
HECW1
HECW2
HERC1
HERC2
HERC4
HUWE1
ITCH
KAT2B
KCMF1
LNX1
LNX2
LRSAM1
LTN1
MAP3K1
MAPT
MARCHF3
MARCHF5
MARCHF6
MARCHF7
MDM2
MDM4
MEX3A
MEX3C
MGRN1
MIB1
MIB2
MID1
MID2
MKRN2
MKRN3
MUL1
MYCBP2
MYLIP
NAT10
NBR1
NEDD4
NEDD4L
NFKB1
NFKBIA
NPR1
NSMCE1
OBI1
OTUB1
PDZRN3
PELI1
PHF7
PHRF1
PJA1
PJA2
PMAIP1
POLL
POLM
PRKN
QSOX1
RAD18
RAF1
RAG1
RBCK1
RBX1
RC3H1
RC3H2
RCHY1
RELA
RFFL
RFWD3
RIGI
RING1
RLIM
RMND5B
RNF10
RNF103
RNF11
RNF111
RNF114
RNF115
RNF122
RNF123
RNF126
RNF13
RNF130
RNF135
RNF138
RNF14
RNF144A
RNF146
RNF149
RNF150
RNF151
RNF166
RNF167
RNF168
RNF170
RNF181
RNF185
RNF186
RNF19A
RNF19B
RNF2
RNF20
RNF213
RNF216
RNF220
RNF224
RNF25
RNF26
RNF31
RNF34
RNF38
RNF4
RNF40
RNF43
RNF5
RNF7
RNF8
RSPRY1
RTF2
SIAH1
SIAH2
SMURF1
SMURF2
SNCA
SOCS6
SPOP
STAM2
STK11
STUB1
SYVN1
TOPORS
TP53
TRAF2
TRAF6
TRAF7
TRAIP
TRIM10
TRIM11
TRIM13
TRIM17
TRIM2
TRIM21
TRIM23
TRIM25
TRIM26
TRIM27
TRIM28
TRIM3
TRIM31
TRIM32
TRIM33
TRIM34
TRIM35
TRIM36
TRIM37
TRIM38
TRIM39
TRIM41
TRIM43
TRIM45
TRIM46
TRIM47
TRIM5
TRIM50
TRIM54
TRIM55
TRIM62
TRIM63
TRIM65
TRIM7
TRIM8
TRIP12
TTC3
UBA1
UBA3
UBA5
UBA6
UBASH3B
UBD
UBE3A
UBE3C
UBE4A
UBE4B
UBOX5
UBR1
UBR2
UBR3
UBR4
UBR5
UFM1
UHRF1
UHRF2
UVSSA
VHL
VPS11
VPS18
WSB1
WWP1
WWP2
XIAP
ZNRF1
ZNRF2
ZNRF4
Entrez ID
7189
7322
HPRD ID
03833
04268
Ensembl ID
ENSG00000175104
ENSG00000131508
Uniprot IDs
Q9Y4K3
P62837
PDB IDs
1LB4
1LB5
1LB6
2ECI
2JMD
3HCS
3HCT
3HCU
4Z8M
5ZUJ
6A33
7L3L
8HZ2
1UR6
1W4U
2CLW
2ESK
2ESO
2ESP
2ESQ
3A33
3JVZ
3JW0
3L1Y
3TGD
3ZNI
4A49
4A4B
4A4C
4AUQ
4DDG
4DDI
4LDT
4V3K
4V3L
4WZ3
5D0K
5D0M
5D1K
5D1L
5D1M
5EDV
5MNJ
5ULF
5ULH
5ULK
5VZW
5ZBU
6HPR
6M2C
6SQO
6SQR
6SQS
6TTU
6W7Z
6W9D
7AI0
7AI1
7BOL
7R71
8B3I
8GBQ
8GCB
8GRM
8JWJ
8JWU
8V0D
8VK8
8VK9
Enriched GO Terms of Interacting Partners
?
Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Intracellular Signal Transduction
Protein Modification Process
Protein Metabolic Process
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of Signal Transduction
Intracellular Signal Transduction
Regulation Of Signal Transduction
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Post-translational Protein Modification
Regulation Of Signaling
Regulation Of Cell Communication
Innate Immune Response-activating Signaling Pathway
Positive Regulation Of Defense Response
Pattern Recognition Receptor Signaling Pathway
Activation Of Innate Immune Response
Response To Stress
Immune Response-regulating Signaling Pathway
Regulation Of Defense Response
Modification-dependent Protein Catabolic Process
Proteolysis Involved In Protein Catabolic Process
Positive Regulation Of Innate Immune Response
Immune Response-activating Signaling Pathway
Cell Surface Receptor Signaling Pathway
Signal Transduction
Proteolysis
Cytosol
Activation Of Immune Response
Ubiquitin-dependent Protein Catabolic Process
Ubiquitin Protein Ligase Binding
Protein Polyubiquitination
Positive Regulation Of Immune Response
Regulation Of Innate Immune Response
Macromolecule Metabolic Process
Regulation Of Immune Response
Defense Response
Protein Kinase Activity
MAPK Cascade
Cytoplasmic Pattern Recognition Receptor Signaling Pathway
Regulation Of Apoptotic Process
Regulation Of Programmed Cell Death
Transferase Activity
Negative Regulation Of Signal Transduction
Regulation Of Cytokine-mediated Signaling Pathway
Protein Ubiquitination
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Immune System Process
Negative Regulation Of Signaling
Ubiquitin Protein Ligase Activity
Protein Ubiquitination
Protein Modification By Small Protein Conjugation
Post-translational Protein Modification
Ubiquitin-protein Transferase Activity
Protein Modification Process
Transferase Activity
Protein Metabolic Process
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Protein Polyubiquitination
Proteolysis Involved In Protein Catabolic Process
Zinc Ion Binding
Macromolecule Catabolic Process
Proteolysis
Macromolecule Metabolic Process
Metal Ion Binding
Catabolic Process
Protein Autoubiquitination
Proteasomal Protein Catabolic Process
Protein Catabolic Process
Protein K48-linked Ubiquitination
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Protein K63-linked Ubiquitination
Ubiquitin Ligase Complex
Cytoplasm
Protein Monoubiquitination
Response To Stress
Regulation Of Signal Transduction
Immune System Process
Cellular Response To Stress
Regulation Of Signaling
Regulation Of Cell Communication
Negative Regulation Of Signal Transduction
Regulation Of Intracellular Signal Transduction
Ubiquitin-ubiquitin Ligase Activity
Positive Regulation Of Protein Ubiquitination
Suppression Of Viral Release By Host
Innate Immune Response
Positive Regulation Of Catabolic Process
Ubiquitin Protein Ligase Binding
Positive Regulation Of Post-translational Protein Modification
Regulation Of Post-translational Protein Modification
Negative Regulation Of Signaling
Negative Regulation Of Cell Communication
Ubiquitin Binding
Positive Regulation Of Protein Metabolic Process
Regulation Of Protein Ubiquitination
Canonical NF-kappaB Signal Transduction
Defense Response To Symbiont
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Tagcloud (Intersection)
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