Wiki-Pi
About
Search
People
Updates
Search
TRAF6 and STK17A
Number of citations of the paper that reports this interaction (PubMedID
32265222
)
0
Data Source:
BioGRID
(two hybrid, affinity chromatography technology)
TRAF6
STK17A
Description
TNF receptor associated factor 6
serine/threonine kinase 17a
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Lipid Droplet
Cytosol
Plasma Membrane
Cell Cortex
Cytoplasmic Side Of Plasma Membrane
Endosome Membrane
Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
Protein-containing Complex
CD40 Receptor Complex
Perinuclear Region Of Cytoplasm
Glutamatergic Synapse
Nucleus
Plasma Membrane
Nuclear Speck
Molecular Function
Ubiquitin-protein Transferase Activity
Tumor Necrosis Factor Receptor Binding
Protein Binding
Zinc Ion Binding
Transferase Activity
Enzyme Binding
Protein-macromolecule Adaptor Activity
Ubiquitin Conjugating Enzyme Binding
Ubiquitin-ubiquitin Ligase Activity
Signaling Adaptor Activity
Identical Protein Binding
Histone Deacetylase Binding
Protein Kinase B Binding
Metal Ion Binding
Ubiquitin Protein Ligase Activity
Nucleotide Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
ATP Binding
Kinase Activity
Transferase Activity
Protein Serine Kinase Activity
Biological Process
Autophagosome Assembly
Negative Regulation Of Transcription By RNA Polymerase II
Protein Polyubiquitination
Ossification
In Utero Embryonic Development
Neural Tube Closure
Stimulatory C-type Lectin Receptor Signaling Pathway
Immune System Process
Regulation Of Immunoglobulin Production
Positive Regulation Of T Cell Cytokine Production
Cytoplasmic Pattern Recognition Receptor Signaling Pathway
MyD88-dependent Toll-like Receptor Signaling Pathway
Immune Response
DNA Damage Response
Signal Transduction
Canonical NF-kappaB Signal Transduction
MRNA Transcription
Animal Organ Morphogenesis
Protein Ubiquitination
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II
CD40 Signaling Pathway
Osteoclast Differentiation
Positive Regulation Of Protein Ubiquitination
Lipopolysaccharide-mediated Signaling Pathway
Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway
Activation Of Protein Kinase Activity
Positive Regulation Of Type I Interferon Production
Positive Regulation Of Interleukin-12 Production
Positive Regulation Of Interleukin-2 Production
Positive Regulation Of Interleukin-6 Production
Tumor Necrosis Factor-mediated Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
TRIF-dependent Toll-like Receptor Signaling Pathway
Non-canonical NF-kappaB Signal Transduction
Fc-epsilon Receptor Signaling Pathway
Interleukin-33-mediated Signaling Pathway
Interleukin-17A-mediated Signaling Pathway
T-helper 1 Type Immune Response
Positive Regulation Of T Cell Proliferation
Odontogenesis Of Dentin-containing Tooth
Defense Response To Bacterium
Regulation Of Apoptotic Process
Myeloid Dendritic Cell Differentiation
Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Negative Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of JUN Kinase Activity
Innate Immune Response
Bone Resorption
Positive Regulation Of Osteoclast Differentiation
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of JNK Cascade
Bone Remodeling
Cell Development
T Cell Receptor Signaling Pathway
Positive Regulation Of NF-kappaB Transcription Factor Activity
Protein Autoubiquitination
Interleukin-1-mediated Signaling Pathway
Protein K63-linked Ubiquitination
Response To Interleukin-1
Protein K48-linked Ubiquitination
Cellular Response To Lipopolysaccharide
Cellular Response To Cytokine Stimulus
Interleukin-17-mediated Signaling Pathway
Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane
Antiviral Innate Immune Response
Intracellular Signaling Cassette
Protein Branched Polyubiquitination
Cellular Response To Oxygen-containing Compound
Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell
Protein Phosphorylation
Apoptotic Process
Intracellular Signal Transduction
Positive Regulation Of Apoptotic Process
Positive Regulation Of Fibroblast Apoptotic Process
Regulation Of Reactive Oxygen Species Metabolic Process
Pathways
PIP3 activates AKT signaling
MyD88:MAL(TIRAP) cascade initiated on plasma membrane
NOD1/2 Signaling Pathway
TICAM1, RIP1-mediated IKK complex recruitment
Regulated proteolysis of p75NTR
Downstream TCR signaling
NRIF signals cell death from the nucleus
NRIF signals cell death from the nucleus
p75NTR recruits signalling complexes
NF-kB is activated and signals survival
FCERI mediated NF-kB activation
TAK1-dependent IKK and NF-kappa-B activation
activated TAK1 mediates p38 MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
CLEC7A (Dectin-1) signaling
Ub-specific processing proteases
Ovarian tumor domain proteases
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
TICAM1,TRAF6-dependent induction of TAK1 complex
Interleukin-1 signaling
TRAF6 mediated IRF7 activation
TRAF6 mediated NF-kB activation
TRAF6 mediated NF-kB activation
IRAK1 recruits IKK complex
IKK complex recruitment mediated by RIP1
IRAK2 mediated activation of TAK1 complex
TRAF6-mediated induction of TAK1 complex within TLR4 complex
Alpha-protein kinase 1 signaling pathway
SARS-CoV-1 activates/modulates innate immune responses
SARS-CoV-2 activates/modulates innate and adaptive immune responses
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
MyD88 dependent cascade initiated on endosome
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
Regulation of NF-kappa B signaling
MyD88 cascade initiated on plasma membrane
Drugs
Fostamatinib
Diseases
GWAS
Idiopathic inflammatory myopathy (
26362759
)
Metabolite levels (
23823483
)
Rheumatoid arthritis (
24390342
30423114
)
HDL cholesterol levels in HIV infection (
33109212
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Interacting Genes
184 interacting genes:
ABL1
AKT1
APP
ATM
ATP6V1E1
ATXN3
BANK1
BCL3
BEX3
BMPR1B
BRSK2
CAV1
CBL
CD40
CUL5
CYLD
DLG4
DNA2
ECSIT
EDA2R
EDARADD
FADD
FAM177A1
FHL2
FYN
GART
GTF2I
H2AX
H2BC21
HNRNPA1
HSD17B10
HSPA4
IL17RB
IPMK
IQUB
IRAK1
IRAK2
IRAK3
IRAK4
IRF5
IRF7
IRF8
JAK2
KCNQ1
LIMD1
LNX1
MALT1
MAP2K1
MAP2K6
MAP2K7
MAP3K11
MAP3K14
MAP3K3
MAP3K5
MAP3K7
MAP3K8
MAPK14
MAPK8
MAPT
MAST2
MATR3
MAVS
MBP
MCL1
MEOX2
MTOR
MTURN
NEAT1
NGFR
NOL3
NTRK1
NTRK2
NUMBL
OTUB1
OTUB2
OTUD7B
PEDS1-UBE2V1
PELI3
PFN1
PHLDA1
PINK1
PLEKHF2
PLEKHO1
POLI
PPP4C
PRKCZ
PSMB5
PSMC1
PSMC2
PSMC3
PSMD1
PSMD12
PSMD13
PSMD6
PSMD7
PTPN6
RAD23A
RIPK1
RIPK2
RIPK3
RNF114
RNF152
RNF31
RPL3
RPS2
RPS20
RPS27A
RSAD2
SIGIRR
SPHK1
SPOP
SQSTM1
SRC
STAMBP
STK17A
STK26
STRADB
STUB1
SUFU
SYK
TAB1
TAB2
TAB3
TANK
TAX1BP1
TDP2
TGFBR1
TICAM1
TICAM2
TIFA
TIRAP
TLR3
TNFAIP3
TNFRSF11A
TNFRSF13B
TNFRSF19
TNFSF11
TRAF1
TRAF2
TRAF3IP1
TRAF3IP2
TRAF4
TRAF5
TRAF7
TRAFD1
TRAM1
TRIM17
TRIM25
TRIM37
TTC3
TXNIP
UBB
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E1
UBE2I
UBE2L3
UBE2N
UBE2V1
UBOX5
UBTD1
UBXN7
UEVLD
USP1
USP15
USP2
USP21
USP39
USP7
VPS52
XIAP
YBX1
YES1
YOD1
YWHAQ
ZBTB25
ZDHHC11
ZFAND5
ZMYND11
ZNF675
ZRANB1
1 interacting genes:
TRAF6
Entrez ID
7189
9263
HPRD ID
03833
05288
Ensembl ID
ENSG00000175104
ENSG00000164543
Uniprot IDs
Q9Y4K3
Q9UEE5
PDB IDs
1LB4
1LB5
1LB6
2ECI
2JMD
3HCS
3HCT
3HCU
4Z8M
5ZUJ
6A33
7L3L
8HZ2
7QUE
7QUF
Enriched GO Terms of Interacting Partners
?
Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Intracellular Signal Transduction
Protein Modification Process
Protein Metabolic Process
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of Signal Transduction
Intracellular Signal Transduction
Regulation Of Signal Transduction
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Post-translational Protein Modification
Regulation Of Signaling
Regulation Of Cell Communication
Innate Immune Response-activating Signaling Pathway
Positive Regulation Of Defense Response
Pattern Recognition Receptor Signaling Pathway
Activation Of Innate Immune Response
Response To Stress
Immune Response-regulating Signaling Pathway
Regulation Of Defense Response
Modification-dependent Protein Catabolic Process
Proteolysis Involved In Protein Catabolic Process
Positive Regulation Of Innate Immune Response
Immune Response-activating Signaling Pathway
Cell Surface Receptor Signaling Pathway
Signal Transduction
Proteolysis
Cytosol
Activation Of Immune Response
Ubiquitin-dependent Protein Catabolic Process
Ubiquitin Protein Ligase Binding
Protein Polyubiquitination
Positive Regulation Of Immune Response
Regulation Of Innate Immune Response
Macromolecule Metabolic Process
Regulation Of Immune Response
Defense Response
Protein Kinase Activity
MAPK Cascade
Cytoplasmic Pattern Recognition Receptor Signaling Pathway
Regulation Of Apoptotic Process
Regulation Of Programmed Cell Death
Transferase Activity
Negative Regulation Of Signal Transduction
Regulation Of Cytokine-mediated Signaling Pathway
Protein Ubiquitination
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Immune System Process
Negative Regulation Of Signaling
Bone Resorption
Positive Regulation Of T Cell Cytokine Production
MyD88-dependent Toll-like Receptor Signaling Pathway
Ubiquitin-ubiquitin Ligase Activity
CD40 Signaling Pathway
Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway
Regulation Of Receptor Localization To Synapse
Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane
Non-canonical NF-kappaB Signal Transduction
Bone Remodeling
Myeloid Dendritic Cell Differentiation
Interleukin-1-mediated Signaling Pathway
Positive Regulation Of Osteoclast Differentiation
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II
CD40 Receptor Complex
Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell
Regulation Of Protein Localization To Synapse
Stimulatory C-type Lectin Receptor Signaling Pathway
Positive Regulation Of JUN Kinase Activity
Ubiquitin Conjugating Enzyme Binding
MyD88-independent Toll-like Receptor Signaling Pathway
Endolysosomal Toll-like Receptor Signaling Pathway
TRIF-dependent Toll-like Receptor Signaling Pathway
Tumor Necrosis Factor Receptor Binding
Interleukin-17A-mediated Signaling Pathway
Protein Branched Polyubiquitination
Protein Kinase B Binding
Interleukin-33-mediated Signaling Pathway
Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II
Myeloid Dendritic Cell Activation
Toll-like Receptor 3 Signaling Pathway
Cellular Response To Lectin
Regulation Of Lipopolysaccharide-mediated Signaling Pathway
T-helper 1 Type Immune Response
Fc-epsilon Receptor Signaling Pathway
Interleukin-17-mediated Signaling Pathway
Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II
Dendritic Cell Differentiation
Positive Regulation Of Interleukin-2 Production
Positive Regulation Of MAP Kinase Activity
Activation Of Protein Kinase Activity
Antigen Processing And Presentation Of Exogenous Peptide Antigen
Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell
Regulation Of T Cell Cytokine Production
Lipopolysaccharide-mediated Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Positive Regulation Of Interleukin-12 Production
Cell Surface Toll-like Receptor Signaling Pathway
Osteoclast Differentiation
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?