TRAF6 and ATM

Number of citations of the paper that reports this interaction (PMID 20932475)
49

Data Source:
BioGRID (pull down)

		TRAF6	ATM
Gene Name		TNF receptor-associated factor 6, E3 ubiquitin protein ligase	ATM serine/threonine kinase
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Mitochondrion Lipid Particle Cytosol Plasma Membrane Cell Cortex Cytoplasmic Side Of Plasma Membrane Endosome Membrane CD40 Receptor Complex Protein Complex Perinuclear Region Of Cytoplasm	Chromosome, Telomeric Region Nucleoplasm Spindle Cytoplasmic Membrane-bounded Vesicle
	Molecular Function	Ubiquitin-protein Transferase Activity Tumor Necrosis Factor Receptor Binding Protein Binding Zinc Ion Binding Ligase Activity Protein Kinase Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin Protein Ligase Binding Thioesterase Binding Histone Deacetylase Binding Protein Kinase B Binding Protein N-terminus Binding	DNA Binding Protein Serine/threonine Kinase Activity DNA-dependent Protein Kinase Activity Protein Binding ATP Binding 1-phosphatidylinositol-3-kinase Activity Protein Complex Binding Histone Serine Kinase Activity Protein Dimerization Activity Protein N-terminus Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Activation Of MAPK Activity Protein Polyubiquitination Ossification Neural Tube Closure Toll-like Receptor Signaling Pathway Positive Regulation Of T Cell Cytokine Production MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Protein Complex Assembly I-kappaB Kinase/NF-kappaB Signaling Activation Of NF-kappaB-inducing Kinase Activity JNK Cascade Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Osteoclast Differentiation Membrane Protein Intracellular Domain Proteolysis Positive Regulation Of Protein Ubiquitination Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Activation Of Protein Kinase Activity Positive Regulation Of Interleukin-2 Production Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway T-helper 1 Type Immune Response Positive Regulation Of T Cell Proliferation Odontogenesis Of Dentin-containing Tooth Myeloid Dendritic Cell Differentiation Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of JUN Kinase Activity Positive Regulation Of Interleukin-12 Biosynthetic Process Innate Immune Response Positive Regulation Of Interleukin-6 Biosynthetic Process Bone Resorption Positive Regulation Of Osteoclast Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Neurotrophin TRK Receptor Signaling Pathway Cell Development Positive Regulation Of Smooth Muscle Cell Proliferation T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Activation Regulation Of Immunoglobulin Secretion Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Stress-activated MAPK Cascade Protein Autoubiquitination Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Interleukin-1-mediated Signaling Pathway Protein K63-linked Ubiquitination Response To Interleukin-1 Cellular Response To Lipopolysaccharide Apoptotic Signaling Pathway Positive Regulation Of Transcription Regulatory Region DNA Binding	Telomere Maintenance Double-strand Break Repair Via Homologous Recombination Response To Hypoxia Somitogenesis Pre-B Cell Allelic Exclusion DNA Repair Double-strand Break Repair Protein Phosphorylation Cellular Response To DNA Damage Stimulus DNA Damage Induced Protein Phosphorylation DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Cell Cycle Arrest Mitotic Spindle Assembly Checkpoint Reciprocal Meiotic Recombination Signal Transduction Brain Development Heart Development Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Ionizing Radiation Peptidyl-serine Phosphorylation Negative Regulation Of B Cell Proliferation V(D)J Recombination Cellular Response To Heat Histone-serine Phosphorylation Phosphatidylinositol-3-phosphate Biosynthetic Process Lipoprotein Catabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Neuron Apoptotic Process Protein Autophosphorylation Oocyte Development Neuron Apoptotic Process Histone MRNA Catabolic Process Cellular Response To Gamma Radiation Signal Transduction Involved In Mitotic G2 DNA Damage Checkpoint Replicative Senescence Regulation Of Cellular Response To Heat
Pathways		NF-kB is activated and signals survival TRAF6 mediated induction of TAK1 complex IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation IRAK1 recruits IKK complex Toll Like Receptor TLR1:TLR2 Cascade FCERI mediated NF-kB activation Toll Like Receptor 5 (TLR5) Cascade NOD1/2 Signaling Pathway MyD88 dependent cascade initiated on endosome Toll Like Receptor 9 (TLR9) Cascade IRAK1 recruits IKK complex activated TAK1 mediates p38 MAPK activation Regulated proteolysis of p75NTR IRAK2 mediated activation of TAK1 complex IRAK2 mediated activation of TAK1 complex TRIF-mediated TLR3/TLR4 signaling Toll Like Receptor 2 (TLR2) Cascade Signaling by Interleukins TCR signaling NRIF signals cell death from the nucleus Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade Fc epsilon receptor (FCERI) signaling Interleukin-1 signaling Adaptive Immune System TAK1 activates NFkB by phosphorylation and activation of IKKs complex Downstream TCR signaling p75NTR recruits signalling complexes Toll Like Receptor 7/8 (TLR7/8) Cascade Toll Like Receptor TLR6:TLR2 Cascade Activated TLR4 signalling MyD88 cascade initiated on plasma membrane p75NTR signals via NF-kB MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Innate Immune System JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Signalling by NGF Cell death signalling via NRAGE, NRIF and NADE IKK complex recruitment mediated by RIP1 MAP kinase activation in TLR cascade Cytokine Signaling in Immune system p75 NTR receptor-mediated signalling MyD88-independent cascade RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	Ubiquitin Mediated Degradation of Phosphorylated Cdc25A Fanconi Anemia pathway G2/M Checkpoints Cellular Senescence p53-Dependent G1/S DNA damage checkpoint p53-Dependent G1 DNA Damage Response Regulation of the Fanconi anemia pathway Stabilization of p53 p53-Independent DNA Damage Response Homologous recombination repair of replication-independent double-strand breaks p53-Independent G1/S DNA damage checkpoint Double-Strand Break Repair G1/S DNA Damage Checkpoints ATM mediated phosphorylation of repair proteins DNA Damage/Telomere Stress Induced Senescence Meiotic recombination ATM mediated response to DNA double-strand break G2/M DNA damage checkpoint Regulation of HSF1-mediated heat shock response Cellular response to heat stress Autodegradation of the E3 ubiquitin ligase COP1 Homologous Recombination Repair Recruitment of repair and signaling proteins to double-strand breaks Cell Cycle Checkpoints
Drugs
Diseases
GWAS			Melanoma ( 21983787) Response to metformin ( 21186350 21845381)
Protein-Protein Interactions		144 interactors: ABL1 APP ATM ATP6V1E1 ATXN3 BECN1 BMPR1B CALCOCO2 CASP8 CAV1 CBL CD40 CYLD ECSIT EDA2R EDARADD FHL2 FYN GTF2I HIF1A HSPA4 IKBKG IL17RB IRAK1 IRAK2 IRAK3 IRAK4 IRF5 IRF7 IRF8 JAK2 KCNQ1 MALT1 MAP2K1 MAP2K6 MAP2K7 MAP3K11 MAP3K14 MAP3K3 MAP3K5 MAP3K7 MAP3K8 MAPK14 MAPK8 MAPT MAST2 MAVS MBP MCL1 MEOX2 MTOR NGFR NGFRAP1 NTRK1 NTRK2 NUMBL OTUB1 OTUB2 OTUD7B PELI3 PINK1 PLEKHF2 PLEKHO1 POLI PPP4C PRKCZ PSMB5 PSMC1 PSMC2 PSMC3 PSMD1 PSMD12 PSMD13 PSMD6 PSMD7 PTPN6 RIPK2 RNF114 SIGIRR SPHK1 SPOP SQSTM1 SRC STAMBP STRADB STUB1 SYK TAB1 TAB2 TAB3 TAX1BP1 TDP2 TGFBR1 TICAM1 TICAM2 TIFA TIRAP TLR3 TMEM189-UBE2V1 TNFAIP3 TNFRSF11A TNFRSF13B TNFRSF19 TNFSF11 TRAF1 TRAF2 TRAF3IP1 TRAF3IP2 TRAF4 TRAF5 TRAF7 TRAFD1 TRAM1 TRIM17 TRIM25 TRIM37 UBB UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2I UBE2L3 UBE2N UBE2V1 UBOX5 UEVLD USP1 USP15 USP2 USP21 USP39 USP4 USP5 USP7 VPS52 XIAP YBX1 YES1 ZFAND5 ZMYND11 ZNF675 ZRANB1	76 interactors: AATF ABL1 AP1B1 AP2A2 AP2B1 AP3B2 ATR BCL10 BLM BRCA1 BRCA2 CDC6 CDKN2C CHD4 CHEK1 CHEK2 CREB1 CSNK1D CXXC5 DAXX DCLRE1C DDX1 DYRK2 E2F1 E4F1 EEF1E1 EIF3E EIF4EBP1 EXO1 FANCD2 FOXO3 H2AFX HIF1A KAT5 KAT8 LIG4 MCM2 MDC1 MDM2 MDM4 MRE11A NBN PARP1 PEX5 POLR2A PRKDC PTS RAD17 RAD51 RAD9A RBBP8 RHEB RNF20 RNF40 RPA1 RPA2 SMC1A SOCS1 SPSB1 STK11 TCL1A TELO2 TERF1 TERF2 TIPARP TOP1 TOPBP1 TP53 TP53BP1 TRAF6 TREX1 VPRBP WRN XPA XRCC5 ZEB1
Entrez ID		7189	472
HPRD ID		03833	06347
Ensembl ID			ENSG00000149311
Uniprot IDs		Q9Y4K3	Q13315
PDB IDs		1LB4 1LB5 1LB6 2ECI 2JMD 3HCS 3HCT 3HCU
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Signal Transduction Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Signaling Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Transferase Activity Positive Regulation Of Protein Modification Process Regulation Of Cellular Protein Metabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Protein Metabolic Process Intracellular Signal Transduction Cellular Protein Modification Process Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Toll-like Receptor 4 Signaling Pathway Cell Communication Signal Transduction Signaling Immune System Process Activation Of Innate Immune Response Regulation Of Intracellular Signal Transduction Cellular Response To Stimulus Regulation Of Innate Immune Response Toll-like Receptor Signaling Pathway Response To Stress Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Innate Immune Response Response To Stimulus Regulation Of Apoptotic Process Positive Regulation Of Cellular Metabolic Process Defense Response TRIF-dependent Toll-like Receptor Signaling Pathway Immune Response-regulating Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of Cell Death Response To Organic Substance Cell Death Death Cellular Protein Metabolic Process Innate Immune Response Activation Of Protein Kinase Activity Programmed Cell Death Cellular Response To Organic Substance Cellular Response To Stress Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Immune System Process	Cellular Response To DNA Damage Stimulus Cellular Response To Stress DNA Metabolic Process DNA Repair Double-strand Break Repair Cell Cycle Process Cell Cycle Response To Stress DNA Recombination Response To Ionizing Radiation Cell Cycle Checkpoint DNA Damage Checkpoint DNA Replication Response To Radiation Chromosome Organization Double-strand Break Repair Via Homologous Recombination Recombinational Repair Heterocycle Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Cell Cycle Mitotic Cell Cycle Process Regulation Of Mitotic Cell Cycle Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Biosynthetic Process Mitotic Cell Cycle Regulation Of Cell Cycle Nitrogen Compound Metabolic Process Response To Abiotic Stimulus Cellular Response To Stimulus Negative Regulation Of DNA Replication Negative Regulation Of Cellular Metabolic Process Telomere Maintenance Signal Transduction In Response To DNA Damage Negative Regulation Of DNA Metabolic Process Organelle Organization Negative Regulation Of Mitotic Cell Cycle Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Response To Stimulus Mitotic Cell Cycle Checkpoint Regulation Of DNA Replication Cellular Metabolic Process Signal Transduction By P53 Class Mediator Apoptotic Signaling Pathway Mitotic DNA Damage Checkpoint Mitotic DNA Integrity Checkpoint Regulation Of Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process
Tagcloud ?		adhesion affinity bind cd40 cd40ct cytoplasmic dispensable dominantly extensive icam ikappabalpha implicated incapable intercellular jak3 kappab mediators molecule much mutants necrosis residues strongly tail traf2 traf3 traf5 transduction	absent alpha ataxia basis cytokines defective degradation fibroblasts fully ikappab immunoprecipitated induces ionizing kappab mediates mitogens nf oxidants oxidative product radiation rapid restores stimuli stresses telangiectasia tnf transfected understood
Tagcloud (Difference) ?		adhesion affinity bind cd40 cd40ct cytoplasmic dispensable dominantly extensive icam ikappabalpha implicated incapable intercellular jak3 mediators molecule much mutants necrosis residues strongly tail traf2 traf3 traf5 transduction	absent alpha ataxia basis cytokines defective degradation fibroblasts fully ikappab immunoprecipitated induces ionizing mediates mitogens nf oxidants oxidative product radiation rapid restores stimuli stresses telangiectasia tnf transfected understood
Tagcloud (Intersection) ?		kappab