PDE4DIP and ZFYVE21

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		PDE4DIP	ZFYVE21
Description		phosphodiesterase 4D interacting protein	zinc finger FYVE-type containing 21
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Golgi Apparatus Centrosome Microtubule Organizing Center Cytoskeleton Myofibril Cortical Microtubule Plus-end	Endosome Focal Adhesion Cytoplasmic Vesicle Anchoring Junction
	Molecular Function	Protein Binding Enzyme Binding Molecular Adaptor Activity	Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Centrosome Cycle Astral Microtubule Organization Protein-containing Complex Assembly Positive Regulation Of Microtubule Nucleation Regulation Of Golgi Organization
Pathways
Drugs
Diseases
GWAS		Capecitabine sensitivity ( 22864933) Cutaneous mastocytosis ( 32752121) Macrovascular complications in type 2 diabetes ( 33430853) Mastocytosis ( 32752121)	Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Body mass index ( 26426971) Hemoglobin ( 32888494) Schizophrenia ( 25056061 29483656)
Interacting Genes		88 interacting genes: ADH1B AEN AIRIM AKTIP ANKRD11 ARNT2 BYSL CCDC146 CCDC198 CDC5L CDKN1A CHCHD3 CLIP4 CWF19L2 DSCAM DSCR9 EGR2 FAM161A FAM50B FAM74A4 FCHSD2 FES FHL1 GADD45G GFI1B GOLGA8EP GOLGA8F HAUS1 HOXB5 HOXC8 ITSN2 KDM1A KLC3 KLC4 KRAS KRT18 KRT31 LAMTOR3 LENG1 LIN37 LMO4 MAPRE3 MIF4GD MTUS2 MYBPC2 MYOM1 NAA10 NEFL NEK2 OSGEP PDE4D PEA15 PFDN1 PIAS4 PPP1R18 PRNP PRPF31 PYGM RSPH1 RTP5 SCNM1 SDCBP SH2D4A SHFL SMN1 SNCA TEAD4 TFIP11 TK1 TNIK TRAF4 TULP3 UTP14C VAC14 ZBTB24 ZBTB38 ZBTB4 ZFYVE21 ZKSCAN3 ZNF124 ZNF408 ZNF410 ZNF414 ZNF512B ZNF581 ZNF587 ZNF696 ZSCAN26	28 interacting genes: AGTRAP ARL6IP1 CAPN2 CMTM4 FBXO7 KRT31 KRT38 KRT40 KRTAP10-3 KRTAP10-5 KRTAP10-8 KRTAP5-9 MID2 MTUS2 NOTCH2NLA PDE4DIP PTK2 PYCARD RABAC1 REEP6 RTN4 RUBCN SIAH1 SMIM5 TRAF1 TRIM27 TUBB YIF1A
Entrez ID		9659	79038
HPRD ID		10482	15733
Ensembl ID		ENSG00000178104	ENSG00000100711
Uniprot IDs		A0A075B749 A0A8Q3SI21 A0A8Q3SI83 A0A8Q3WM32 A0A994J5E0 E9PQG4 Q5VU43	Q9BQ24
PDB IDs			2RRF
Enriched GO Terms of Interacting Partners?		Nucleoplasm Zinc Ion Binding Nucleus Cytoskeleton Organization Cytoskeleton Protein Binding DNA-binding Transcription Factor Activity	Intermediate Filament Keratin Filament Vascular Endothelial Cell Response To Oscillatory Fluid Shear Stress Endoplasmic Reticulum Tubular Network Formation Identical Protein Binding Phosphatidylinositol 3-kinase Inhibitor Activity Endoplasmic Reticulum Tubular Network Membrane Organization Structural Constituent Of Skin Epidermis Supramolecular Fiber Organization Endoplasmic Reticulum Organization Structural Molecule Activity Intermediate Filament Organization Vascular Endothelial Cell Response To Fluid Shear Stress Negative Regulation Of Viral Transcription Regulation Of Autophagy Endoplasmic Reticulum Membrane Organization Suppression Of Viral Release By Host Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Regulation Of Viral Transcription Endoplasmic Reticulum Tubular Network Organization Positive Regulation Of Mononuclear Cell Migration Endoplasmic Reticulum Tubular Network Positive Regulation Of Macrophage Cytokine Production Positive Regulation Of Macrophage Migration Regulation Of Apoptotic Process Cellular Response To Fluid Shear Stress Regulation Of Cytoskeleton Organization Cytosol Ubiquitin Protein Ligase Binding Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Myosin I Binding Positive Regulation Of Myeloid Leukocyte Cytokine Production Involved In Immune Response Negative Regulation Of Vasculogenesis Positive Regulation Of ERBB3 Signaling Pathway Cell Adhesion Involved In Sprouting Angiogenesis Regulation Of Mononuclear Cell Migration Cytoskeleton Positive Regulation Of Leukocyte Migration Regulation Of Macrophage Cytokine Production Regulation Of Programmed Cell Death Microtubule Response To Fluid Shear Stress
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