RLIM and BRF1

Number of citations of the paper that reports this interaction (PubMedID 30413534)
48

Data Source:
BioGRID (enzymatic study)

		RLIM	BRF1
Description		ring finger protein, LIM domain interacting	BRF1 general transcription factor IIIB subunit
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Transcription Repressor Complex	Transcription Factor TFIIIB Complex Nucleus Nucleoplasm Transcription Preinitiation Complex
	Molecular Function	Transcription Corepressor Activity Ubiquitin-protein Transferase Activity Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	RNA Polymerase III General Transcription Initiation Factor Activity RNA Polymerase III Type 3 Promoter Sequence-specific DNA Binding Protein Binding Zinc Ion Binding TBP-class Protein Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Negative Regulation Of DNA-templated Transcription Random Inactivation Of X Chromosome	DNA-templated Transcription Initiation Transcription By RNA Polymerase III Transcription Initiation At RNA Polymerase III Promoter RRNA Transcription TRNA Transcription Transcription Preinitiation Complex Assembly
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter
Drugs
Diseases
GWAS		Brain asymmetrical skew (horizontal) ( 33836062)	Huntington's disease progression ( 28642124) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean platelet volume ( 22139419 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Platelet count ( 27863252 29403010 32888494) Platelet distribution width ( 27863252) Red blood cell count ( 32888494)
Interacting Genes		31 interacting genes: BRF1 CDK2 CFLAR ESR1 ISL1 LDB1 LDB2 LHX1 LHX2 LHX3 LIMK1 LMO2 LMO4 LNX2 MDM2 PDLIM1 REXO1 SIN3A SMURF2 SNX17 SS18L1 STAT6 TERF1 TNFAIP3 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2K	16 interacting genes: APP CSNK2A1 DTNBP1 GTF3C3 GTF3C4 GTF3C5 PCBD2 POLR3F RB1 RBL1 RBL2 RHOU RLIM TBP TP53 UBC
Entrez ID		51132	2972
HPRD ID		02304	05361
Ensembl ID		ENSG00000131263	ENSG00000185024
Uniprot IDs		Q9NVW2	Q92994 V9HVY2
PDB IDs		6W7Z 6W9A 6W9D
Enriched GO Terms of Interacting Partners?		Transcription Regulator Complex Ubiquitin-protein Transferase Activity Ubiquitin Conjugating Enzyme Activity Protein K48-linked Ubiquitination Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Biosynthetic Process Nucleus Negative Regulation Of Macromolecule Biosynthetic Process Protein Polyubiquitination Negative Regulation Of Transcription By RNA Polymerase II Protein Ubiquitination Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Post-translational Protein Modification Negative Regulation Of DNA-templated Transcription Negative Regulation Of Metabolic Process Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process LIM Domain Binding Spinal Cord Motor Neuron Cell Fate Specification Central Nervous System Neuron Differentiation Neuron Differentiation Protein Modification By Small Protein Conjugation Negative Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Modification-dependent Protein Catabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Cell Differentiation In Spinal Cord Spinal Cord Association Neuron Differentiation Macromolecule Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Proteolysis Involved In Protein Catabolic Process Proteolysis Regulation Of Macromolecule Biosynthetic Process Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Protein Modification Process Motor Neuron Axon Guidance Regulation Of Gene Expression Neuron Fate Specification	Transcription By RNA Polymerase III RNA Polymerase III General Transcription Initiation Factor Activity Regulation Of Lipid Kinase Activity RRNA Transcription Transcription Factor TFIIIC Complex 5S Class RRNA Transcription By RNA Polymerase III DNA-templated Transcription TRNA Transcription By RNA Polymerase III TRNA Transcription Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Cell Cycle Phase Transition Negative Regulation Of Cell Cycle Process Chromatin Organization Nucleobase-containing Compound Biosynthetic Process Glial Cell Apoptotic Process RNA Metabolic Process Negative Regulation Of Cell Cycle Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Mitotic Cell Cycle Phase Transition Nucleoplasm Transcription Initiation At RNA Polymerase III Promoter Regulation Of Cell Cycle G1/S Phase Transition DNA Binding Negative Regulation Of Gene Expression Negative Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Phase Transition Promoter-specific Chromatin Binding DNA-templated Transcription Initiation Nucleus Transcription Regulator Complex RRNA Metabolic Process Regulation Of Mitotic Cell Cycle Epigenetic Regulation Of Gene Expression Regulation Of DNA-templated Transcription Negative Regulation Of Glial Cell Proliferation Regulation Of RNA Biosynthetic Process Core Promoter Sequence-specific DNA Binding Regulation Of Phosphorus Metabolic Process PML Body Macromolecule Biosynthetic Process Nucleic Acid Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of RNA Metabolic Process Molecular Function Activator Activity Chromatin Remodeling Regulation Of Cell Cycle Disordered Domain Specific Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Receptor Internalization
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