RLIM and REXO1

Number of citations of the paper that reports this interaction (PubMedID 22596162)
0

Data Source:
BioGRID (enzymatic study)

		RLIM	REXO1
Description		ring finger protein, LIM domain interacting	RNA exonuclease 1 homolog
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Transcription Repressor Complex	Nucleus Nucleoplasm Nuclear Body
	Molecular Function	Transcription Corepressor Activity Ubiquitin-protein Transferase Activity Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Nucleic Acid Binding Nuclease Activity Exonuclease Activity Hydrolase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Negative Regulation Of DNA-templated Transcription Random Inactivation Of X Chromosome	RRNA 3'-end Processing
Pathways		Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Brain asymmetrical skew (horizontal) ( 33836062)	Body mass index ( 29273807) Essential hypertension (time to event) ( 32589924) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494)
Interacting Genes		31 interacting genes: BRF1 CDK2 CFLAR ESR1 ISL1 LDB1 LDB2 LHX1 LHX2 LHX3 LIMK1 LMO2 LMO4 LNX2 MDM2 PDLIM1 REXO1 SIN3A SMURF2 SNX17 SS18L1 STAT6 TERF1 TNFAIP3 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2K	4 interacting genes: ELOA PAFAH1B2 RLIM TCEA1
Entrez ID		51132	57455
HPRD ID		02304	15478
Ensembl ID		ENSG00000131263	ENSG00000079313
Uniprot IDs		Q9NVW2	Q8N1G1
PDB IDs		6W7Z 6W9A 6W9D
Enriched GO Terms of Interacting Partners?		Transcription Regulator Complex Ubiquitin-protein Transferase Activity Ubiquitin Conjugating Enzyme Activity Protein K48-linked Ubiquitination Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Biosynthetic Process Nucleus Negative Regulation Of Macromolecule Biosynthetic Process Protein Polyubiquitination Negative Regulation Of Transcription By RNA Polymerase II Protein Ubiquitination Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Post-translational Protein Modification Negative Regulation Of DNA-templated Transcription Negative Regulation Of Metabolic Process Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process LIM Domain Binding Spinal Cord Motor Neuron Cell Fate Specification Central Nervous System Neuron Differentiation Neuron Differentiation Protein Modification By Small Protein Conjugation Negative Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Modification-dependent Protein Catabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Cell Differentiation In Spinal Cord Spinal Cord Association Neuron Differentiation Macromolecule Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Proteolysis Involved In Protein Catabolic Process Proteolysis Regulation Of Macromolecule Biosynthetic Process Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Protein Modification Process Motor Neuron Axon Guidance Regulation Of Gene Expression Neuron Fate Specification	Transcription Elongation By RNA Polymerase II DNA-templated Transcription Elongation Platelet-activating Factor Acetyltransferase Activity 1-alkyl-2-acetylglycerophosphocholine Esterase Complex Elongin Complex 1-alkyl-2-acetylglycerophosphocholine Esterase Activity Transcription By RNA Polymerase II
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