RLIM and LHX1

Number of citations of the paper that reports this interaction (PubMedID 11882901)
0

Data Source:
HPRD (in vitro)

		RLIM	LHX1
Description		ring finger protein, LIM domain interacting	LIM homeobox 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Transcription Repressor Complex	Chromatin Nucleus Transcription Regulator Complex Protein-containing Complex
	Molecular Function	Transcription Corepressor Activity Ubiquitin-protein Transferase Activity Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Negative Regulation Of DNA-templated Transcription Random Inactivation Of X Chromosome	Urogenital System Development Metanephros Development Ureteric Bud Development Branching Involved In Ureteric Bud Morphogenesis Gastrulation With Mouth Forming Second Ectoderm Formation Endoderm Formation Kidney Development Mesonephros Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Cell-cell Signaling Pattern Specification Process Nervous System Development Endoderm Development Motor Neuron Axon Guidance Anatomical Structure Morphogenesis Post-embryonic Development Embryonic Pattern Specification Animal Organ Morphogenesis Anterior/posterior Axis Specification Anterior/posterior Pattern Specification Dorsal/ventral Pattern Formation Regulation Of Gene Expression Retina Layer Formation Spinal Cord Development Ventral Spinal Cord Development Spinal Cord Association Neuron Differentiation Telencephalon Development Cerebellum Development Cerebellar Purkinje Cell Differentiation Forebrain Regionalization Cerebellar Purkinje Cell-granule Cell Precursor Cell Signaling Cell Differentiation Neuron Differentiation Somite Rostral/caudal Axis Specification Metanephric Part Of Ureteric Bud Development Oviduct Epithelium Development Uterine Epithelium Development Nephric Duct Elongation Positive Regulation Of Embryonic Development Cellular Response To Fibroblast Growth Factor Stimulus Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Mesendoderm Development Anatomical Structure Formation Involved In Morphogenesis Embryonic Viscerocranium Morphogenesis System Development Pronephros Development Retina Development In Camera-type Eye Embryonic Retina Morphogenesis In Camera-type Eye Uterus Development Oviduct Development Cervix Development Vagina Development Head Development Epithelium Development Paramesonephric Duct Development Comma-shaped Body Morphogenesis S-shaped Body Morphogenesis Renal Vesicle Morphogenesis Mesonephric Tubule Development Mesonephric Duct Development Nephric Duct Morphogenesis Ureter Morphogenesis Metanephric Glomerulus Development Metanephric Comma-shaped Body Morphogenesis Metanephric Renal Vesicle Morphogenesis Metanephric S-shaped Body Morphogenesis Primitive Streak Formation Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Dorsal Spinal Cord Interneuron Posterior Axon Guidance Lateral Motor Column Neuron Migration Positive Regulation Of Gastrulation Positive Regulation Of Anterior Head Development Positive Regulation Of Nephron Tubule Epithelial Cell Differentiation
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Formation of intermediate mesoderm Formation of the nephric duct Nephron development
Drugs
Diseases
GWAS		Brain asymmetrical skew (horizontal) ( 33836062)	Alzheimer's disease ( 30636644) Body mass index ( 26426971) Carotid intima media thickness x smoking interaction ( 32117412) HDL cholesterol x physical activity interaction (1df test) ( 30670697) HDL cholesterol x physical activity interaction (2df test) ( 30670697) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		31 interacting genes: BRF1 CDK2 CFLAR ESR1 ISL1 LDB1 LDB2 LHX1 LHX2 LHX3 LIMK1 LMO2 LMO4 LNX2 MDM2 PDLIM1 REXO1 SIN3A SMURF2 SNX17 SS18L1 STAT6 TERF1 TNFAIP3 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2K	9 interacting genes: CATSPERT FOXA2 ISL1 KANK2 LDB1 LHX3 OTX2 RLIM SCNM1
Entrez ID		51132	3975
HPRD ID		02304	09067
Ensembl ID		ENSG00000131263	ENSG00000273706
Uniprot IDs		Q9NVW2	P48742 Q58F18
PDB IDs		6W7Z 6W9A 6W9D
Enriched GO Terms of Interacting Partners?		Transcription Regulator Complex Ubiquitin-protein Transferase Activity Ubiquitin Conjugating Enzyme Activity Protein K48-linked Ubiquitination Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Biosynthetic Process Nucleus Negative Regulation Of Macromolecule Biosynthetic Process Protein Polyubiquitination Negative Regulation Of Transcription By RNA Polymerase II Protein Ubiquitination Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Post-translational Protein Modification Negative Regulation Of DNA-templated Transcription Negative Regulation Of Metabolic Process Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process LIM Domain Binding Spinal Cord Motor Neuron Cell Fate Specification Central Nervous System Neuron Differentiation Neuron Differentiation Protein Modification By Small Protein Conjugation Negative Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Modification-dependent Protein Catabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Cell Differentiation In Spinal Cord Spinal Cord Association Neuron Differentiation Macromolecule Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Proteolysis Involved In Protein Catabolic Process Proteolysis Regulation Of Macromolecule Biosynthetic Process Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Protein Modification Process Motor Neuron Axon Guidance Regulation Of Gene Expression Neuron Fate Specification	Neuron Differentiation Positive Regulation Of Gastrulation RNA Polymerase II-specific DNA-binding Transcription Factor Binding LIM Domain Binding Spinal Cord Motor Neuron Cell Fate Specification Cell Fate Specification Primitive Streak Formation Regulation Of Gastrulation Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Embryonic Development Central Nervous System Neuron Differentiation DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription By RNA Polymerase II Neuron Fate Specification Pituitary Gland Development Dopaminergic Neuron Differentiation Chromatin Regulation Of Intracellular Estrogen Receptor Signaling Pathway Neuron Projection Guidance Cell Differentiation In Spinal Cord Axon Guidance Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Cellular Developmental Process Transcription Regulator Complex Positive Regulation Of Transcription By RNA Polymerase II Transcription Cis-regulatory Region Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of RNA Metabolic Process Anatomical Structure Morphogenesis Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Anatomical Structure Morphogenesis Regulation Of Embryonic Development Regulation Of Smoothened Signaling Pathway Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Medial Motor Column Neuron Differentiation Prolactin Secreting Cell Differentiation Regulation Of Myofibroblast Contraction Negative Regulation Of Vitamin D Receptor Signaling Pathway Negative Regulation Of Programmed Cell Death Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Developmental Process
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