RLIM and TNFAIP3

Number of citations of the paper that reports this interaction (PubMedID 23105109)
42

Data Source:
BioGRID (two hybrid)

		RLIM	TNFAIP3
Description		ring finger protein, LIM domain interacting	TNF alpha induced protein 3
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Transcription Repressor Complex	Nucleus Cytoplasm Lysosome Cytosol Extracellular Exosome
	Molecular Function	Transcription Corepressor Activity Ubiquitin-protein Transferase Activity Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Protease Binding DNA Binding Catalytic Activity Ubiquitin-protein Transferase Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Zinc Ion Binding Transferase Activity Hydrolase Activity Enzyme Binding Kinase Binding Identical Protein Binding Ubiquitin Binding Metal Ion Binding K63-linked Deubiquitinase Activity K63-linked Polyubiquitin Modification-dependent Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Negative Regulation Of DNA-templated Transcription Random Inactivation Of X Chromosome	B-1 B Cell Homeostasis Response To Molecule Of Bacterial Origin Immune System Process Regulation Of Germinal Center Formation Negative Regulation Of Chronic Inflammatory Response Proteolysis Apoptotic Process Inflammatory Response Cytoskeleton Organization Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Cell Migration Protein Deubiquitination Positive Regulation Of Wnt Signaling Pathway Negative Regulation Of Protein Ubiquitination Response To Muramyl Dipeptide Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Interleukin-2 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Toll-like Receptor 2 Signaling Pathway Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Negative Regulation Of Toll-like Receptor 5 Signaling Pathway Protein K11-linked Deubiquitination Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Negative Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Regulation Of Cell Population Proliferation Negative Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Protein Catabolic Process Negative Regulation Of Bone Resorption Negative Regulation Of Innate Immune Response Negative Regulation Of Smooth Muscle Cell Proliferation Regulation Of Defense Response To Virus By Host Negative Regulation Of Inflammatory Response Negative Regulation Of B Cell Activation Regulation Of Vascular Wound Healing Cellular Response To Hydrogen Peroxide Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Protein K63-linked Deubiquitination Protein K48-linked Ubiquitination Protein K48-linked Deubiquitination Cellular Response To Lipopolysaccharide Protein Deubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Tolerance Induction To Lipopolysaccharide Establishment Of Protein Localization To Vacuole Negative Regulation Of Osteoclast Proliferation Cellular Response To Oxygen-containing Compound Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Hepatocyte Proliferation Negative Regulation Of CD40 Signaling Pathway Negative Regulation Of Endothelial Cell Apoptotic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	NOD1/2 Signaling Pathway TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway Ovarian tumor domain proteases Negative regulators of DDX58/IFIH1 signaling
Drugs
Diseases
GWAS		Brain asymmetrical skew (horizontal) ( 33836062)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 32296059) Autoimmune traits (pleiotropy) ( 30572963) Cardiac Troponin-T levels ( 23247143) Celiac disease ( 20190752 22057235) Celiac disease and Rheumatoid arthritis ( 26546613) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Cutaneous psoriasis ( 26626624) Hodgkin's lymphoma ( 30194254) Inflammatory bowel disease ( 23128233) Inflammatory skin disease ( 25574825) Malaria ( 31844061) Multiple sclerosis ( 24076602) Phosphatidylcholine-ether levels ( 31551469) Primary biliary cholangitis ( 26394269) Psoriasis ( 25574825 19169254 25903422 20953190 23143594) Psoriasis vulgaris ( 26626624) Rheumatoid arthritis ( 24449572 24390342 23143596 20453841 32723749 30423114 17982456) Rheumatoid arthritis (ACPA-positive) ( 24532676 23143596) Sjögren's syndrome ( 24097066 24097067) Systemic lupus erythematosus ( 19165918 28714469 27399966 26663301 26502338 23273568 19838195 19838193) Systemic lupus erythematosus and Systemic sclerosis ( 23740937) Systemic lupus erythematosus or rheumatoid arthritis ( 27193031) Systemic sclerosis ( 28314753) Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655) Tonsillectomy ( 28928442 27182965) Type 1 diabetes ( 34127860)
Interacting Genes		31 interacting genes: BRF1 CDK2 CFLAR ESR1 ISL1 LDB1 LDB2 LHX1 LHX2 LHX3 LIMK1 LMO2 LMO4 LNX2 MDM2 PDLIM1 REXO1 SIN3A SMURF2 SNX17 SS18L1 STAT6 TERF1 TNFAIP3 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2K	61 interacting genes: ANKRD13D ARRDC3 ATP2A2 CALCOCO2 CCDC50 CCDC90B CHUK CLEC4G COL1A1 DRC4 FABP4 GIT2 GNAI2 IKBKB IKBKG LAPTM5 LNX1 MAP3K5 OCLN PCBP1 PFKL PIBF1 PSMA7 RAD23A RBCK1 RIPK1 RLIM RNF11 RNF14 RNF168 RNF216 RNF5 RPS15 RPS20 SNAI1 TAX1BP1 TICAM1 TIFA TNIP1 TNIP2 TRAF1 TRAF2 TRAF6 TRIM2 TRIM23 TRIM3 TRIM5 TRIM8 UBC UBE2D1 UBE2N UBQLN1 UBXN6 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ ZFAND5 ZNF251
Entrez ID		51132	7128
HPRD ID		02304	01857
Ensembl ID		ENSG00000131263	ENSG00000118503
Uniprot IDs		Q9NVW2	P21580
PDB IDs		6W7Z 6W9A 6W9D	2EQE 2EQF 2EQG 2VFJ 3DKB 3OJ3 3OJ4 3VUW 3VUX 3VUY 3ZJD 3ZJE 3ZJF 3ZJG 5LRX 5V3B 5V3P
Enriched GO Terms of Interacting Partners?		Transcription Regulator Complex Ubiquitin-protein Transferase Activity Ubiquitin Conjugating Enzyme Activity Protein K48-linked Ubiquitination Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Biosynthetic Process Nucleus Negative Regulation Of Macromolecule Biosynthetic Process Protein Polyubiquitination Negative Regulation Of Transcription By RNA Polymerase II Protein Ubiquitination Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Post-translational Protein Modification Negative Regulation Of DNA-templated Transcription Negative Regulation Of Metabolic Process Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process LIM Domain Binding Spinal Cord Motor Neuron Cell Fate Specification Central Nervous System Neuron Differentiation Neuron Differentiation Protein Modification By Small Protein Conjugation Negative Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Modification-dependent Protein Catabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Cell Differentiation In Spinal Cord Spinal Cord Association Neuron Differentiation Macromolecule Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Proteolysis Involved In Protein Catabolic Process Proteolysis Regulation Of Macromolecule Biosynthetic Process Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Protein Modification Process Motor Neuron Axon Guidance Regulation Of Gene Expression Neuron Fate Specification	Protein Ubiquitination Protein Polyubiquitination Protein Modification By Small Protein Conjugation Regulation Of Canonical NF-kappaB Signal Transduction Post-translational Protein Modification Ubiquitin Protein Ligase Activity Regulation Of Intracellular Signal Transduction Ubiquitin-protein Transferase Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Modification-dependent Protein Catabolic Process Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Canonical NF-kappaB Signal Transduction Proteolysis Involved In Protein Catabolic Process Regulation Of Signal Transduction Positive Regulation Of DNA-binding Transcription Factor Activity Ubiquitin-dependent Protein Catabolic Process Cytoplasm Positive Regulation Of Intracellular Signal Transduction Macromolecule Catabolic Process Regulation Of Immune Response Protein Modification Process Cytosol Activation Of Innate Immune Response Activation Of Immune Response Protein K63-linked Ubiquitination Immune Response-activating Signaling Pathway Pattern Recognition Receptor Signaling Pathway Signaling Adaptor Activity Protein Metabolic Process Positive Regulation Of Signal Transduction Identical Protein Binding Catabolic Process Innate Immune Response-activating Signaling Pathway Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Immune Response Positive Regulation Of Metabolic Process Tumor Necrosis Factor-mediated Signaling Pathway Immune Response-regulating Signaling Pathway Protein Catabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Innate Immune Response Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Defense Response Protein Sequestering Activity Positive Regulation Of Innate Immune Response Positive Regulation Of Immune System Process Proteasomal Protein Catabolic Process Cell Surface Toll-like Receptor Signaling Pathway
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