FAM124A and DOCK8

Number of citations: 56 (PubMedID 25416956)
Data Source: BioGRID (two hybrid)

		FAM124A	DOCK8
Name		family with sequence similarity 124 member A	dedicator of cytokinesis 8
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	None	Cytoplasm Cytosol Plasma Membrane Membrane Cell Leading Edge Leading Edge Membrane Lamellipodium Membrane Cell Projection
	Molecular Function	Protein Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding
	Biological Process	None	Immunological Synapse Formation Small GTPase-mediated Signal Transduction Regulation Of Rho Protein Signal Transduction Dendritic Cell Migration Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction Memory T Cell Proliferation Negative Regulation Of T Cell Apoptotic Process Positive Regulation Of Establishment Of T Cell Polarity Cellular Response To Chemokine Positive Regulation Of T Cell Migration
Pathways		None	CDC42 GTPase cycle RAC1 GTPase cycle RHOJ GTPase cycle Factors involved in megakaryocyte development and platelet production
Diseases		None	Non-syndromic autosomal dominant mental retardation
GWAS		Cerebral amyloid angiopathy x sex interaction in Alzheimer’s disease ( 34020725 ) Cerebrospinal fluid clusterin levels ( 26545630 ) Lipoprotein (a) levels ( 30108283 ) Metabolite levels ( 23823483 ) Placental abruption ( 29884306 ) Refractive error ( 32231278 ) Rheumatoid arthritis (ACPA-negative) ( 24532677 )	Blond vs. brown/black hair color ( 30531825 ) Granulocyte count ( 27863252 ) Granulocyte percentage of myeloid white cells ( 27863252 ) Heel bone mineral density ( 30598549 ) Mean platelet volume ( 22139419 27863252 32888494 ) Monocyte percentage of white cells ( 32888494 ) Myeloid white cell count ( 27863252 ) Neutrophil count ( 27863252 32888494 ) Neutrophil percentage of white cells ( 32888494 ) Nevus count ( 30429480 ) Nevus count or cutaneous melanoma ( 32341527 30429480 ) Obesity-related traits ( 23251661 ) Platelet count ( 27863252 32888494 ) Platelet distribution width ( 27863252 32888494 ) Post bronchodilator FEV1 ( 26634245 ) Red cell distribution width ( 32888494 ) Sum basophil neutrophil counts ( 27863252 ) Sum neutrophil eosinophil counts ( 27863252 ) White blood cell count ( 27863252 32888494 ) Youthful appearance (self-reported) ( 32339537 )
Interacting Genes		30 interacting genes: BEND7 CCDC33 CEP70 CGGBP1 DOCK8 FOXP2 IHO1 IL16 INO80E KIFC3 LNX1 NCK2 NKAP PHC2 PRKG1 RAB3IP RBM10 ROCK1 SAXO1 SRPK1 STAC3 THAP1 TLE5 TRIM41 TRIM54 ZBTB44 ZFP64 ZNF165 ZNF250 ZZZ3	27 interacting genes: BYSL CARHSP1 CDC42 CEBPA CHMP2A COG6 DGCR6 EXOSC5 FAM124A FAM161A FANCL FBXL12 HBZ HSF2BP KRT40 MED30 MEOX2 MRPL38 MTG1 PIMREG RAC1 RHOJ RHOQ RTP5 SMAD2 ZFC3H1 ZNF581
Entrez ID		220108	81704
HPRD ID		08704	10920
Ensembl ID		ENSG00000150510	ENSG00000107099
Uniprot IDs		Q86V42	E2J6M5 E2J6M6 Q8NF50
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Identical Protein Binding Zinc Ion Binding	GBD Domain Binding G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Membrane Invagination Thioesterase Binding GTPase Activity Golgi Transport Complex Establishment Or Maintenance Of Cell Polarity GTP Binding Cytoplasmic Exosome (RNase Complex)