FAM124A and RAB3IP

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		FAM124A	RAB3IP
Description		family with sequence similarity 124 member A	RAB3A interacting protein
Image		No pdb structure
GO Annotations	Cellular Component		Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Cytoskeleton Lamellipodium Vesicle Ciliary Basal Body Cell Projection Perinuclear Region Of Cytoplasm Proximal Dendrite
	Molecular Function	Protein Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding Identical Protein Binding GTPase Binding
	Biological Process		Protein Targeting To Membrane Golgi To Plasma Membrane Transport Protein Transport Negative Regulation Of Filopodium Assembly Cilium Assembly Ciliary Basal Body-plasma Membrane Docking
Pathways			Anchoring of the basal body to the plasma membrane VxPx cargo-targeting to cilium BBSome-mediated cargo-targeting to cilium RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases
GWAS		Cerebral amyloid angiopathy x sex interaction in Alzheimer’s disease ( 34020725) Cerebrospinal fluid clusterin levels ( 26545630) Lipoprotein (a) levels ( 30108283) Metabolite levels ( 23823483) Placental abruption ( 29884306) Refractive error ( 32231278) Rheumatoid arthritis (ACPA-negative) ( 24532677)	Diastolic blood pressure ( 27841878) Height ( 28552196) Logical memory (delayed recall) in normal cognition ( 29274321)
Interacting Genes		30 interacting genes: BEND7 CCDC33 CEP70 CGGBP1 DOCK8 FOXP2 IHO1 IL16 INO80E KIFC3 LNX1 NCK2 NKAP PHC2 PRKG1 RAB3IP RBM10 ROCK1 SAXO1 SRPK1 STAC3 THAP1 TLE5 TRIM41 TRIM54 ZBTB44 ZFP64 ZNF165 ZNF250 ZZZ3	32 interacting genes: BANP CCDC196 CHCHD3 DNAJB13 FAM124A KRT40 MB21D2 MBD3 MVP NAA10 PEG10 PKN1 PLOD3 PPL PRKAB2 RAB11A RAB3A RAB3D RAB3IL1 RAB8A RAB8B RUFY1 SFN SSX2 SUV39H2 TBC1D21 TEPSIN TRAPPC6A TXNDC5 ZBTB16 ZNF410 ZNF76
Entrez ID		220108	117177
HPRD ID		08704	10565
Ensembl ID		ENSG00000150510	ENSG00000127328
Uniprot IDs		Q86V42	Q96QF0
PDB IDs			4LHX 4LHY 4LHZ 4UJ3 4UJ4 4UJ5 6F6P
Enriched GO Terms of Interacting Partners?		Identical Protein Binding Zinc Ion Binding	Myosin V Binding Protein Transport Synaptic Vesicle Regulation Of Neuronal Synaptic Plasticity Establishment Of Protein Localization To Postsynaptic Membrane Neurotransmitter Receptor Transport To Postsynaptic Membrane Neurotransmitter Receptor Transport To Plasma Membrane Neurotransmitter Receptor Transport, Endosome To Postsynaptic Membrane Neurotransmitter Receptor Transport, Endosome To Plasma Membrane Exocytosis Plasma Membrane To Endosome Transport Intracellular Protein Localization Vesicle Organization GTPase Activity Vesicle-mediated Transport Endosome To Plasma Membrane Protein Transport Neurotransmitter Receptor Transport Endocytic Recycling Trans-Golgi Network Transport Vesicle Endosome Establishment Of Protein Localization Phagocytic Vesicle GTP Binding Vesicle-mediated Transport In Synapse GTP-dependent Protein Binding Secretion By Cell Cytoplasmic Vesicle Recycling Endosome Membrane Extracellular Exosome Regulation Of Long-term Neuronal Synaptic Plasticity Trans-Golgi Network Membrane Organelle Organization Glycerol-3-phosphate Dehydrogenase (quinone) Activity Protein Localization To Postsynapse Protein Localization To Postsynaptic Membrane Endosomal Transport Regulation Of Presynaptic Dense Core Granule Exocytosis Evoked Neurotransmitter Secretion Negative Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Centromeric Synaptic Vesicle Endosomal Processing Coated Vesicle Membrane Organelle Fusion
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