FAM124A and NKAP

Number of citations: 0 (PubMedID 16189514)
Data Source: BioGRID (two hybrid), HPRD (two hybrid)

		FAM124A	NKAP
Name		family with sequence similarity 124 member A	NFKB activating protein
Structure		No pdb structure
GO Annotations	Cellular Component	None	Nucleus Nucleoplasm Cytosol
	Molecular Function	Protein Binding	Chromatin Binding RNA Binding Protein Binding Chromatin DNA Binding
	Biological Process	None	Negative Regulation Of Transcription By RNA Polymerase II Notch Signaling Pathway Hemopoiesis Granulocyte Differentiation T Cell Differentiation In Thymus Somatic Stem Cell Population Maintenance Negative Regulation Of DNA-templated Transcription Positive Regulation Of Alpha-beta T Cell Differentiation Hematopoietic Stem Cell Proliferation
Pathways		None	mRNA Splicing - Major Pathway
GWAS		Cerebral amyloid angiopathy x sex interaction in Alzheimer’s disease ( 34020725 ) Cerebrospinal fluid clusterin levels ( 26545630 ) Lipoprotein (a) levels ( 30108283 ) Metabolite levels ( 23823483 ) Placental abruption ( 29884306 ) Refractive error ( 32231278 ) Rheumatoid arthritis (ACPA-negative) ( 24532677 )	No GWAS studies recorded
Interacting Genes		30 interacting genes: BEND7 CCDC33 CEP70 CGGBP1 DOCK8 FOXP2 IHO1 IL16 INO80E KIFC3 LNX1 NCK2 NKAP PHC2 PRKG1 RAB3IP RBM10 ROCK1 SAXO1 SRPK1 STAC3 THAP1 TLE5 TRIM41 TRIM54 ZBTB44 ZFP64 ZNF165 ZNF250 ZZZ3	17 interacting genes: AP1M1 CEP70 DHX15 FAM124A FRA10AC1 LUC7L2 OGT PCBP2 PRPF3 PRPF40A RBM39 RBMX2 SRPK1 SRPK2 THAP1 TTC14 U2AF1
Entrez ID		220108	79576
HPRD ID		08704	06666
Ensembl ID		ENSG00000150510	ENSG00000101882
Uniprot IDs		Q86V42	Q8N5F7
PDB IDs		Not available	6QDV 7W5B 8C6J 9FMD
GO Terms Enriched among Interactors		Identical Protein Binding Zinc Ion Binding	RNA Splicing MRNA Metabolic Process MRNA Processing Nuclear Speck RNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Processing RNA Splicing, Via Transesterification Reactions RNA Binding Nucleic Acid Metabolic Process Protein-RNA Complex Assembly Nucleobase-containing Compound Metabolic Process Nucleic Acid Binding Spliceosomal Complex Assembly RS Domain Binding Spliceosomal Complex Nucleoplasm U2-type Prespliceosome U1 SnRNP Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing Macromolecule Metabolic Process Positive Regulation Of Viral Genome Replication Regulation Of RNA Splicing Protein-containing Complex Assembly Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Nucleus Negative Regulation Of Viral Genome Replication Cellular Component Assembly U2-type Precatalytic Spliceosome Positive Regulation Of Viral Process Protein-containing Complex Organization Cajal Body Negative Regulation Of Viral Process Regulation Of Viral Genome Replication U2-type Post-mRNA Release Spliceosomal Complex Protein O-acetylglucosaminyltransferase Activity Innate Immune Response Regulation Of MRNA Metabolic Process Nuclear Speck Organization