FAM124A and ZZZ3

Number of citations: 56 (PubMedID 25416956)
Data Source: BioGRID (two hybrid)

		FAM124A	ZZZ3
Name		family with sequence similarity 124 member A	zinc finger ZZ-type containing 3
Structure		No pdb structure
GO Annotations	Cellular Component	None	Nucleus Nucleoplasm Nucleolus Mitotic Spindle ATAC Complex
	Molecular Function	Protein Binding	DNA Binding Protein Binding Zinc Ion Binding Histone Binding Metal Ion Binding
	Biological Process	None	Chromatin Organization Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Regulation Of Embryonic Development Regulation Of Cell Division Regulation Of Cell Cycle
Pathways		None	HATs acetylate histones Formation of WDR5-containing histone-modifying complexes
GWAS		Cerebral amyloid angiopathy x sex interaction in Alzheimer’s disease ( 34020725 ) Cerebrospinal fluid clusterin levels ( 26545630 ) Lipoprotein (a) levels ( 30108283 ) Metabolite levels ( 23823483 ) Placental abruption ( 29884306 ) Refractive error ( 32231278 ) Rheumatoid arthritis (ACPA-negative) ( 24532677 )	A body shape index ( 34021172 ) Body mass index ( 28448500 ) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500 ) Body mass index in physically active individuals ( 28448500 ) Height ( 31562340 ) Hip circumference ( 25673412 ) Lung adenocarcinoma ( 28604730 ) Lung cancer ( 28604730 ) Obesity ( 23563607 ) Platelet count ( 32888494 ) Type 2 diabetes (age of onset) ( 28060188 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )
Interacting Genes		30 interacting genes: BEND7 CCDC33 CEP70 CGGBP1 DOCK8 FOXP2 IHO1 IL16 INO80E KIFC3 LNX1 NCK2 NKAP PHC2 PRKG1 RAB3IP RBM10 ROCK1 SAXO1 SRPK1 STAC3 THAP1 TLE5 TRIM41 TRIM54 ZBTB44 ZFP64 ZNF165 ZNF250 ZZZ3	21 interacting genes: BLZF1 CARD9 DNAJB11 EFHC2 EPS8 FAM124A GATA1 GOLGA2 IKBKG LZTR1 MAML3 PBXIP1 PCBD2 PICK1 PPP1R13B TRAF2 TRIM22 ZBTB9 ZNF212 ZNF496 ZNF513
Entrez ID		220108	26009
HPRD ID		08704	15907
Ensembl ID		ENSG00000150510	ENSG00000036549
Uniprot IDs		Q86V42	Q8IYH5
PDB IDs		Not available	2FC7 2YUM 6E83 6E86
GO Terms Enriched among Interactors		Identical Protein Binding Zinc Ion Binding	Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Signaling Adaptor Activity Positive Regulation Of RNA Metabolic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Canonical NF-kappaB Signal Transduction Identical Protein Binding