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FAM124A and ROCK1
Number of citations of the paper that reports this interaction (PMID
25416956
)
0
Data Source:
BioGRID
(two hybrid)
FAM124A
ROCK1
Gene Name
family with sequence similarity 124A
Rho-associated, coiled-coil containing protein kinase 1
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Golgi Membrane
Ruffle
Centriole
Cytosol
Cytoskeleton
Plasma Membrane
Lamellipodium
Bleb
Molecular Function
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
GTP-Rho Binding
Metal Ion Binding
Biological Process
Apical Constriction
Protein Phosphorylation
Apoptotic Process
Cellular Component Disassembly Involved In Execution Phase Of Apoptosis
Smooth Muscle Contraction
Leukocyte Cell-cell Adhesion
Signal Transduction
Rho Protein Signal Transduction
Axon Guidance
Negative Regulation Of Angiogenesis
Membrane To Membrane Docking
Actin Cytoskeleton Organization
Regulation Of Cell Adhesion
Bleb Assembly
Regulation Of Actin Cytoskeleton Organization
Negative Regulation Of Neuron Apoptotic Process
Regulation Of Keratinocyte Differentiation
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Ephrin Receptor Signaling Pathway
Leukocyte Migration
Leukocyte Tethering Or Rolling
Myoblast Migration
Regulation Of Stress Fiber Assembly
Regulation Of Focal Adhesion Assembly
Positive Regulation Of Focal Adhesion Assembly
Regulation Of Establishment Of Cell Polarity
Regulation Of Cell Motility
Pathways
Signaling by GPCR
Apoptotic cleavage of cellular proteins
Axon guidance
Semaphorin interactions
Apoptotic execution phase
VEGFA-VEGFR2 Pathway
EPHB-mediated forward signaling
EPHA-mediated growth cone collapse
GPCR downstream signaling
Signaling by VEGF
Programmed Cell Death
EPH-Ephrin signaling
G alpha (12/13) signalling events
Sema4D in semaphorin signaling
Sema4D induced cell migration and growth-cone collapse
Drugs
HYDROXYFASUDIL
(S)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLINE)SULFONYL]-HOMOPIPERAZINE
5-(1,4-DIAZEPAN-1-SULFONYL)ISOQUINOLINE
(R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXANECARBOXAMIDE
Diseases
GWAS
Protein-Protein Interactions
27 interactors:
AES
CCDC33
CCDC36
CEP70
CGGBP1
DOCK8
FAM154A
FOXP2
INO80E
KIFC3
LNX1
NKAP
PHC2
PRKG1
RAB3IP
RBM10
ROCK1
SRPK1
STAC3
THAP1
TRIM41
TRIM54
ZBTB44
ZFP64
ZNF165
ZNF250
ZZZ3
32 interactors:
ADD1
ARHGAP24
C6orf165
CASP3
CASP7
CDC25A
CDC34
CRMP1
DES
DPYSL2
EZR
FAM124A
GFAP
IKBKB
IRS1
ITSN2
LIMK1
LIMK2
LMO2
MAGEB4
MSN
PFN2
POLR3C
PPP1R12A
PTK2
RDX
RHOA
RHOC
RND3
SMAD2
TSG101
VIM
Entrez ID
220108
6093
HPRD ID
08704
03414
Ensembl ID
ENSG00000150510
Uniprot IDs
Q86V42
Q13464
PDB IDs
1S1C
2ESM
2ETK
2ETR
2V55
3D9V
3NCZ
3NDM
3O0Z
3TV7
3TWJ
3V8S
Enriched GO Terms of Interacting Partners
?
RNA Metabolic Process
Transcription, DNA-templated
Gene Expression
RNA Biosynthetic Process
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Macromolecule Biosynthetic Process
Cellular Nitrogen Compound Metabolic Process
Macromolecule Biosynthetic Process
Regulation Of RNA Metabolic Process
Nitrogen Compound Metabolic Process
Putamen Development
Caudate Nucleus Development
Memory T Cell Proliferation
Regulation Of Gene Expression
Regulation Of Nitrogen Compound Metabolic Process
Regulation Of Transcription, DNA-templated
Regulation Of Metabolic Process
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Single Organismal Cell-cell Adhesion
Regulation Of MRNA Splicing, Via Spliceosome
Muscle System Process
Zonula Adherens Maintenance
Regulation Of MRNA Processing
Biosynthetic Process
Leukocyte Cell-cell Adhesion
Positive Regulation Of Anoikis
Cellular Metabolic Process
Regulation Of RNA Splicing
Membrane To Membrane Docking
Vocal Learning
Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis
Apical Constriction
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Righting Reflex
Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis
Regulation Of Cellular Component Organization
Cytoskeleton Organization
Negative Regulation Of Cell Projection Organization
Cellular Component Disassembly Involved In Execution Phase Of Apoptosis
Execution Phase Of Apoptosis
Cell Development
Regulation Of Cell Projection Organization
Cell Differentiation
Positive Regulation Of Metabolic Process
Epithelium Development
Axon Guidance
Movement Of Cell Or Subcellular Component
Actin Filament-based Process
Organelle Organization
Regulation Of Cellular Process
Anatomical Structure Development
Cell Morphogenesis Involved In Differentiation
Skeletal Muscle Satellite Cell Migration
Axonogenesis
Cell Morphogenesis
Neuron Projection Development
Axon Development
Neuron Differentiation
System Development
Cell Morphogenesis Involved In Neuron Differentiation
Regulation Of Neuron Projection Development
Cell Projection Organization
Response To Stimulus
Response To Growth Factor
Establishment Of Endothelial Barrier
Chemotaxis
Regulation Of Metabolic Process
Developmental Process
Enzyme Linked Receptor Protein Signaling Pathway
Generation Of Neurons
Neuron Projection Morphogenesis
Negative Regulation Of Neuron Projection Development
Locomotion
Neuron Development
Wound Healing, Spreading Of Cells
Neurogenesis
Negative Regulation Of Ruffle Assembly
Membrane To Membrane Docking
Tissue Development
Bergmann Glial Cell Differentiation
Positive Regulation Of Stress Fiber Assembly
Regulation Of Cytoskeleton Organization
Multicellular Organismal Development
Endothelial Cell Development
Positive Regulation Of Actin Filament Bundle Assembly
Tagcloud
?
angiogenic
au
contributor
decay
disperse
dispersion
ecs
eliciting
gtpase
herpesvirus
hsp27
kapb
kaposi
kaposin
ks
kshv
latently
likewise
mk2
p115rhogef
pb
pbs
reprogramming
restore
rhoa
ribonucleoprotein
sarcoma
secrete
secretory
Tagcloud (Difference)
?
angiogenic
au
contributor
decay
disperse
dispersion
ecs
eliciting
gtpase
herpesvirus
hsp27
kapb
kaposi
kaposin
ks
kshv
latently
likewise
mk2
p115rhogef
pb
pbs
reprogramming
restore
rhoa
ribonucleoprotein
sarcoma
secrete
secretory
Tagcloud (Intersection)
?