FANCG and CAPN1

Number of citations of the paper that reports this interaction (PMID 20518497)
4

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		FANCG	CAPN1
Gene Name		Fanconi anemia, complementation group G	calpain 1, (mu/I) large subunit
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Nucleolus Cytoplasm Mitochondrion Plasma Membrane Fanconi Anaemia Nuclear Complex	Cytoplasm Cytosol Plasma Membrane Focal Adhesion Membrane Extracellular Vesicular Exosome
	Molecular Function	Damaged DNA Binding Protein Binding	Calcium-dependent Cysteine-type Endopeptidase Activity Calcium Ion Binding Protein Binding
	Biological Process	Cell Cycle Checkpoint Ovarian Follicle Development DNA Repair Mitochondrion Organization Spermatid Development Response To Radiation	Proteolysis Positive Regulation Of Cell Proliferation Extracellular Matrix Disassembly Extracellular Matrix Organization Receptor Catabolic Process
Pathways		Fanconi Anemia pathway	Degradation of the extracellular matrix
Drugs
Diseases
GWAS
Protein-Protein Interactions		22 interactors: BRCA2 BRCC3 CAPN1 CDK1 CYP19A1 CYP2E1 ERCC4 FANCA FANCC FANCE FANCF FTSJ3 GABPB1 HES1 KRT19 PSMB1 RTN2 SAMD3 UIMC1 USHBP1 XRCC3 ZBED1	50 interactors: ACTC1 ACTN2 AES ARF6 BCL2L1 BID CAPNS1 CASP14 CAST CBL CDK5R1 CLEC4G COL1A1 COL3A1 CREG1 CTSC DES ECHS1 F2R F2RL1 FANCA FANCG FHL2 GNG12 GPT GRIN2B HNRNPD IL1A INPP4A ITGB3 KNG1 LAMTOR1 MYBPC3 NDUFB7 NFE2L1 NFKBIA PRMT5 PSEN2 PTGDS RAD21 SH3BGR SLIT3 SPTAN1 SPTBN1 STAT3 SYNE1 TINAGL1 TP53 UFSP2 VIM
Entrez ID		2189	823
HPRD ID		04262	00253
Ensembl ID		ENSG00000221829	ENSG00000014216
Uniprot IDs		O15287 Q53XM5	B2RDI5 B4DWH5 P07384
PDB IDs			1ZCM 2ARY
Enriched GO Terms of Interacting Partners?		Cellular Response To DNA Damage Stimulus DNA Repair DNA Metabolic Process Cellular Response To Stress Double-strand Break Repair Developmental Process Involved In Reproduction Heterocycle Metabolic Process Histone H2A K63-linked Deubiquitination Reproductive Structure Development Reproductive System Development Positive Regulation Of Mitotic Cell Cycle Single Organism Reproductive Process G2 DNA Damage Checkpoint Positive Regulation Of Cell Cycle Response To Stress Cellular Nitrogen Compound Metabolic Process Reproductive Process DNA Damage Checkpoint Nucleobase-containing Compound Metabolic Process Nitrogen Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Mitotic Cell Cycle Cell Cycle Checkpoint Double-strand Break Repair Via Homologous Recombination Recombinational Repair Nucleotide-excision Repair Cell Cycle Cellular Response To Stimulus Protein K63-linked Deubiquitination Female Gonad Development Development Of Primary Female Sexual Characteristics Histone Deubiquitination Cellular Metabolic Process Reproduction Cell Cycle Process Response To Stimulus Response To Ionizing Radiation Positive Regulation Of DNA Metabolic Process Histone Modification Response To X-ray Meiotic Nuclear Division Muscle Cell Development Positive Regulation Of DNA Repair Response To Radiation Response To Reactive Oxygen Species Meiotic Cell Cycle Regulation Of Cell Cycle Gonad Development Nucleotide-excision Repair Involved In Interstrand Cross-link Repair Negative Regulation Of Stomach Neuroendocrine Cell Differentiation	Apoptotic Process Regulation Of Signal Transduction Programmed Cell Death Cell Death Death Movement Of Cell Or Subcellular Component Response To Stimulus Regulation Of Cell Death Regulation Of Signaling Muscle Filament Sliding Actin-myosin Filament Sliding Developmental Process Regulation Of Apoptotic Process Positive Regulation Of Signal Transduction Anatomical Structure Development Organ Development Response To Organic Substance Actin-mediated Cell Contraction Cell Differentiation Cell Development Protein Localization To Nucleus Protein Localization To Organelle System Development Enzyme Linked Receptor Protein Signaling Pathway Actin Filament-based Movement Multicellular Organismal Development Cell Surface Receptor Signaling Pathway Muscle Contraction Response To External Stimulus Anatomical Structure Morphogenesis Cellular Response To Stimulus Cell Activation Regulation Of Cellular Process Muscle System Process Axon Guidance Positive Regulation Of Transport Blood Coagulation Hemostasis Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Cellular Localization Rhythmic Process Platelet Activation Wound Healing Negative Regulation Of Cell Death Positive Regulation Of Cell Death Regulation Of Protein Localization Regulation Of Cellular Component Organization Protein Import Into Nucleus Response To Stress
Tagcloud ?		24h 300mum 513a 5p abp aminobiphenyl array arrays arylamine bioinformatic carcinogen comet damage deregulation eventually exo1 hepg2 lig1 mirna mirnas parallel pcna pcr qrt rad18 repair ung validated xrcc2	5k3 alpl armitage beadchip bovinesnp50 bull catsper1 cohran dehygrogenase ethanolamine etnk1 friesian goldenhelix hibadh hydroxyisobutyrate kelch klhl1 loc785875 mc4r pdzrn4 prkcb rs110596818 rs110827324 rs110876480 rs29011704 sire srd5a2 svs7 trim36
Tagcloud (Difference) ?		24h 300mum 513a 5p abp aminobiphenyl array arrays arylamine bioinformatic carcinogen comet damage deregulation eventually exo1 hepg2 lig1 mirna mirnas parallel pcna pcr qrt rad18 repair ung validated xrcc2	5k3 alpl armitage beadchip bovinesnp50 bull catsper1 cohran dehygrogenase ethanolamine etnk1 friesian goldenhelix hibadh hydroxyisobutyrate kelch klhl1 loc785875 mc4r pdzrn4 prkcb rs110596818 rs110827324 rs110876480 rs29011704 sire srd5a2 svs7 trim36
Tagcloud (Intersection) ?