FANCG and ERCC4

Number of citations of the paper that reports this interaction (PMID 20518486)
6

Data Source:
BioGRID (two hybrid)

		FANCG	ERCC4
Gene Name		Fanconi anemia, complementation group G	excision repair cross-complementation group 4
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Nucleolus Cytoplasm Mitochondrion Plasma Membrane Fanconi Anaemia Nuclear Complex	Nucleotide-excision Repair Complex Nucleotide-excision Repair Factor 1 Complex Chromosome, Telomeric Region Nuclear Chromosome, Telomeric Region Nucleus Nucleoplasm Transcription Factor TFIID Complex
	Molecular Function	Damaged DNA Binding Protein Binding	Single-stranded DNA Endodeoxyribonuclease Activity TFIID-class Transcription Factor Binding Damaged DNA Binding Single-stranded DNA Binding Endodeoxyribonuclease Activity Protein Binding Protein C-terminus Binding Structure-specific DNA Binding Protein N-terminus Binding
	Biological Process	Cell Cycle Checkpoint Ovarian Follicle Development DNA Repair Mitochondrion Organization Spermatid Development Response To Radiation	Resolution Of Meiotic Recombination Intermediates Nucleotide-excision Repair, DNA Damage Removal Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Catabolic Process, Endonucleolytic DNA Repair Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair Nucleotide-excision Repair, DNA Incision, 3'-to Lesion Nucleotide-excision Repair, DNA Incision, 5'-to Lesion Response To UV UV Protection Telomere Maintenance Via Telomere Shortening Negative Regulation Of Telomere Maintenance Nucleotide-excision Repair, DNA Incision Nucleotide-excision Repair Involved In Interstrand Cross-link Repair
Pathways		Fanconi Anemia pathway	Nucleotide Excision Repair Global Genomic NER (GG-NER) Transcription-coupled NER (TC-NER) Formation of incision complex in GG-NER Formation of transcription-coupled NER (TC-NER) repair complex Dual incision reaction in GG-NER Dual incision reaction in TC-NER
Drugs
Diseases
GWAS			Bilirubin levels ( 22085899) Conduct disorder (symptom count) ( 20585324) Metabolic syndrome ( 20694148)
Protein-Protein Interactions		22 interactors: BRCA2 BRCC3 CAPN1 CDK1 CYP19A1 CYP2E1 ERCC4 FANCA FANCC FANCE FANCF FTSJ3 GABPB1 HES1 KRT19 PSMB1 RTN2 SAMD3 UIMC1 USHBP1 XRCC3 ZBED1	7 interactors: ERCC1 FANCG GTF2H1 RAD52 SLX1A SLX4 SPTAN1
Entrez ID		2189	2072
HPRD ID		04262	00594
Ensembl ID		ENSG00000221829	ENSG00000175595
Uniprot IDs		O15287 Q53XM5	Q92889
PDB IDs			1Z00 2A1J 2AQ0 2KN7
Enriched GO Terms of Interacting Partners?		Cellular Response To DNA Damage Stimulus DNA Repair DNA Metabolic Process Cellular Response To Stress Double-strand Break Repair Developmental Process Involved In Reproduction Heterocycle Metabolic Process Histone H2A K63-linked Deubiquitination Reproductive Structure Development Reproductive System Development Positive Regulation Of Mitotic Cell Cycle Single Organism Reproductive Process G2 DNA Damage Checkpoint Positive Regulation Of Cell Cycle Response To Stress Cellular Nitrogen Compound Metabolic Process Reproductive Process DNA Damage Checkpoint Nucleobase-containing Compound Metabolic Process Nitrogen Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Mitotic Cell Cycle Cell Cycle Checkpoint Double-strand Break Repair Via Homologous Recombination Recombinational Repair Nucleotide-excision Repair Cell Cycle Cellular Response To Stimulus Protein K63-linked Deubiquitination Female Gonad Development Development Of Primary Female Sexual Characteristics Histone Deubiquitination Cellular Metabolic Process Reproduction Cell Cycle Process Response To Stimulus Response To Ionizing Radiation Positive Regulation Of DNA Metabolic Process Histone Modification Response To X-ray Meiotic Nuclear Division Muscle Cell Development Positive Regulation Of DNA Repair Response To Radiation Response To Reactive Oxygen Species Meiotic Cell Cycle Regulation Of Cell Cycle Gonad Development Nucleotide-excision Repair Involved In Interstrand Cross-link Repair Negative Regulation Of Stomach Neuroendocrine Cell Differentiation	DNA Repair Cellular Response To DNA Damage Stimulus DNA Catabolic Process Double-strand Break Repair DNA Metabolic Process DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing DNA Recombination Cellular Response To Stress Double-strand Break Repair Via Homologous Recombination Recombinational Repair Nucleotide-excision Repair DNA Catabolic Process, Endonucleolytic DNA Double-strand Break Processing Aromatic Compound Catabolic Process Nucleotide-excision Repair, DNA Damage Removal DNA Catabolic Process, Exonucleolytic Cellular Macromolecule Catabolic Process Response To Stress Transcription-coupled Nucleotide-excision Repair Nucleic Acid Phosphodiester Bond Hydrolysis Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Response To Stimulus Post-embryonic Hemopoiesis Nucleotide-excision Repair, DNA Incision, 5'-to Lesion Nucleotide-excision Repair, DNA Incision, 3'-to Lesion Nitrogen Compound Metabolic Process Catabolic Process Pyrimidine Dimer Repair By Nucleotide-excision Repair Response To Intra-S DNA Damage Checkpoint Signaling DNA Recombinase Assembly Gonad Development Nucleotide-excision Repair, DNA Incision Replicative Cell Aging Development Of Primary Sexual Characteristics Interstrand Cross-link Repair Germ Cell Development Cellular Response To Stimulus Negative Regulation Of Telomere Maintenance Sex Differentiation Pyrimidine Dimer Repair UV Protection Response To Sucrose Regulation Of Telomere Maintenance Response To Radiation Isotype Switching Termination Of RNA Polymerase I Transcription Transcription Elongation From RNA Polymerase I Promoter
Tagcloud ?		24h 300mum 513a 5p abp aminobiphenyl array arrays arylamine bioinformatic carcinogen comet damage deregulation eventually exo1 hepg2 lig1 mirna mirnas parallel pcna pcr qrt rad18 repair ung validated xrcc2	additively additivity adducts african americans bonferroni bulky cancerous carolina corrected departures ds eradicate ercc2 hnc interacted jointly ner os platinum remove rs2607755 rs3136038 rs3136130 rs50871 suggestively uncorrected whites xpc
Tagcloud (Difference) ?		24h 300mum 513a 5p abp aminobiphenyl array arrays arylamine bioinformatic carcinogen comet damage deregulation eventually exo1 hepg2 lig1 mirna mirnas parallel pcna pcr qrt rad18 repair ung validated xrcc2	additively additivity adducts african americans bonferroni bulky cancerous carolina corrected departures ds eradicate ercc2 hnc interacted jointly ner os platinum remove rs2607755 rs3136038 rs3136130 rs50871 suggestively uncorrected whites xpc
Tagcloud (Intersection) ?