NPPB and NPR1

Number of citations: 0 (PubMedID 15709752)
Data Source: BioGRID (pull down), HPRD (in vitro, in vivo)

		NPPB	NPR1
Name		natriuretic peptide B	natriuretic peptide receptor 1
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Protein-containing Complex	Plasma Membrane Membrane Receptor Complex ANPR-A Receptor Complex
	Molecular Function	Signaling Receptor Binding Hormone Activity Protein Binding Diuretic Hormone Activity Guanylate Cyclase Activator Activity Hormone Receptor Binding	Nucleotide Binding Peptide Receptor Activity Guanylate Cyclase Activity Protein Kinase Activity ATP Binding GTP Binding G Protein-coupled Peptide Receptor Activity Lyase Activity Phosphorus-oxygen Lyase Activity Natriuretic Peptide Receptor Activity Peptide Hormone Binding Hormone Binding
	Biological Process	System Process Negative Regulation Of Systemic Arterial Blood Pressure Cardiac Conduction System Development CGMP Biosynthetic Process Protein Folding Cell Surface Receptor Signaling Pathway Receptor Guanylyl Cyclase Signaling Pathway Neuropeptide Signaling Pathway Body Fluid Secretion Regulation Of Blood Pressure Negative Regulation Of Angiogenesis CGMP-mediated Signaling Negative Regulation Of Cell Growth Killing Of Cells Of Another Organism Positive Regulation Of Urine Volume Positive Regulation Of Renal Sodium Excretion Vasodilation Regulation Of Vascular Permeability Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Blood Vessel Diameter Maintenance	CGMP Biosynthetic Process Cell Surface Receptor Signaling Pathway Receptor Guanylyl Cyclase Signaling Pathway G Protein-coupled Receptor Signaling Pathway Body Fluid Secretion Blood Circulation Regulation Of Blood Pressure Cyclic Nucleotide Biosynthetic Process Positive Regulation Of CGMP-mediated Signaling Negative Regulation Of Angiogenesis CGMP-mediated Signaling Negative Regulation Of Cell Growth Intracellular Signal Transduction Positive Regulation Of Urine Volume Positive Regulation Of Renal Sodium Excretion Dopamine Metabolic Process Regulation Of Vascular Permeability Negative Regulation Of Smooth Muscle Cell Proliferation Blood Vessel Diameter Maintenance
Pathways		None	Physiological factors
Drugs		Carvedilol Oxymetholone	Nitroprusside Nitroglycerin Isosorbide dinitrate Amyl Nitrite Erythrityl tetranitrate Nesiritide Ularitide
GWAS		B-type natriuretic peptide levels ( 25561047 29237677 ) B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio ( 29237677 ) Blood pressure ( 21909110 ) Blood protein levels ( 30072576 ) Blood protein levels in cardiovascular risk ( 28369058 ) Diastolic blood pressure ( 27618452 28739976 ) Diastolic blood pressure (cigarette smoking interaction) ( 29455858 ) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962 ) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858 ) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858 ) Hip index ( 34021172 ) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962 ) N-terminal pro B-type natriuretic peptide levels ( 29237677 ) NT-proBNP levels in acute coronary syndrome ( 26908625 ) Pulse pressure ( 30578418 ) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962 ) Systolic blood pressure ( 28739976 27618452 27618447 19430483 ) Systolic blood pressure (cigarette smoking interaction) ( 29455858 ) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858 ) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858 ) Tuberculosis ( 29036319 )	Mean arterial pressure ( 27618448 ) Systolic blood pressure ( 27618448 )
Novel Interactors		4 novel interactors: MTOR SLC45A1 SMARCA4 TNFRSF25	None recorded
Interacting Genes		13 interacting genes: CYSRT1 EWSR1 GEMIN4 HDAC4 KRT40 KRTAP10-3 KRTAP10-9 NOTCH2NLA NPR1 NPR2 NPR3 PSMA3 SERTAD3	7 interacting genes: ATF7IP MTDH NPPA NPPB NPPC PRKG1 UBE2D2
Entrez ID		4879	4881
HPRD ID		08974	00165
Ensembl ID		ENSG00000120937	ENSG00000169418
Uniprot IDs		P16860	A0A140VJE6 P16066
PDB IDs		1YK1 3N56	8TG9 8TGA 9BCL 9BCN 9BCO 9BCP 9BCQ 9BCS 9BCV
GO Terms Enriched among Interactors		Natriuretic Peptide Receptor Activity CGMP Biosynthetic Process Hormone Binding CGMP Metabolic Process Cyclic Nucleotide Biosynthetic Process Peptide Hormone Binding Cyclic Purine Nucleotide Metabolic Process Guanylate Cyclase Activity Positive Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Positive Regulation Of Urine Volume Receptor Guanylyl Cyclase Signaling Pathway Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Keratin Filament Phosphorus-oxygen Lyase Activity Regulation Of Urine Volume Purine Ribonucleotide Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase I Neuronal Action Potential Ribose Phosphate Biosynthetic Process Intermediate Filament Regulation Of Cell Growth Negative Regulation Of Cell Growth Regulation Of Blood Pressure Purine Nucleotide Biosynthetic Process G Protein-coupled Peptide Receptor Activity Regulation Of Myotube Differentiation Regulation Of Transcription By RNA Polymerase I Positive Regulation Of SCF-dependent Proteasomal Ubiquitin-dependent Catabolic Process Blood Circulation Nucleotide Biosynthetic Process ANPR-A Receptor Complex Vestibulocochlear Nerve Maturation Blood Vessel Remodeling D-glucose:proton Symporter Activity Galactose:proton Symporter Activity Regulation Of Glycolytic Process Negative Regulation Of Growth Purine-containing Compound Biosynthetic Process Cajal Body Regulation Of Locomotor Rhythm Regulation Of Carbohydrate Catabolic Process TFIIIC-class Transcription Factor Complex Binding Cumulus Cell Differentiation C-di-GMP Signaling Activation Of Meiosis Involved In Egg Activation Gastric Emptying Sucrose Transport Sucrose:proton Symporter Activity Nucleobase-containing Small Molecule Metabolic Process Regulation Of ATP Metabolic Process	Hormone Receptor Binding CGMP-mediated Signaling Guanylate Cyclase Activator Activity Receptor Guanylyl Cyclase Signaling Pathway CGMP Biosynthetic Process CGMP Metabolic Process Cyclic Nucleotide Biosynthetic Process Blood Vessel Diameter Maintenance Regulation Of Tube Size Cyclic Purine Nucleotide Metabolic Process Regulation Of Vascular Permeability Vasodilation Vascular Process In Circulatory System Positive Regulation Of CGMP-mediated Signaling Circulatory System Process Cell Growth Involved In Cardiac Muscle Cell Development Hormone Activity Regulation Of CGMP-mediated Signaling Purine Ribonucleotide Biosynthetic Process Cardiac Conduction System Development Bone Growth Ribose Phosphate Biosynthetic Process Purine Nucleotide Biosynthetic Process Negative Regulation Of Systemic Arterial Blood Pressure Nucleotide Biosynthetic Process Protein Folding Purine-containing Compound Biosynthetic Process Protein-containing Complex Nucleoside Phosphate Biosynthetic Process Purine Ribonucleotide Metabolic Process Negative Regulation Of Blood Pressure Organ Growth Ribonucleotide Metabolic Process Intracellular Signaling Cassette Ribose Phosphate Metabolic Process Cardiac Muscle Tissue Development Purine Nucleotide Metabolic Process Developmental Growth Negative Regulation Of Collecting Lymphatic Vessel Constriction Signaling Receptor Binding Diuretic Hormone Activity Nucleotide Metabolic Process Carbohydrate Derivative Biosynthetic Process Neuropeptide Signaling Pathway Neuropeptide Receptor Binding Response To 3-methylcholanthrene Purine-containing Compound Metabolic Process Cumulus Cell Differentiation C-di-GMP Signaling Multicellular Organismal Locomotion