NPPB and TNFRSF25

Data Source: HiPPIP (Novel)

		NPPB	TNFRSF25
Name		natriuretic peptide B	TNF receptor superfamily member 25
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Protein-containing Complex	Extracellular Region Cytosol Plasma Membrane Membrane
	Molecular Function	Signaling Receptor Binding Hormone Activity Protein Binding Diuretic Hormone Activity Guanylate Cyclase Activator Activity Hormone Receptor Binding	Tumor Necrosis Factor Receptor Activity Signaling Receptor Activity
	Biological Process	System Process Negative Regulation Of Systemic Arterial Blood Pressure Cardiac Conduction System Development CGMP Biosynthetic Process Protein Folding Cell Surface Receptor Signaling Pathway Receptor Guanylyl Cyclase Signaling Pathway Neuropeptide Signaling Pathway Body Fluid Secretion Regulation Of Blood Pressure Negative Regulation Of Angiogenesis CGMP-mediated Signaling Negative Regulation Of Cell Growth Killing Of Cells Of Another Organism Positive Regulation Of Urine Volume Positive Regulation Of Renal Sodium Excretion Vasodilation Regulation Of Vascular Permeability Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Blood Vessel Diameter Maintenance	Apoptotic Process Signal Transduction Cell Surface Receptor Signaling Pathway Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Apoptotic Process Apoptotic Signaling Pathway
Pathways		None	TNFs bind their physiological receptors
Drugs		Carvedilol Oxymetholone	None
GWAS		B-type natriuretic peptide levels ( 25561047 29237677 ) B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio ( 29237677 ) Blood pressure ( 21909110 ) Blood protein levels ( 30072576 ) Blood protein levels in cardiovascular risk ( 28369058 ) Diastolic blood pressure ( 27618452 28739976 ) Diastolic blood pressure (cigarette smoking interaction) ( 29455858 ) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962 ) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858 ) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858 ) Hip index ( 34021172 ) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962 ) N-terminal pro B-type natriuretic peptide levels ( 29237677 ) NT-proBNP levels in acute coronary syndrome ( 26908625 ) Pulse pressure ( 30578418 ) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962 ) Systolic blood pressure ( 28739976 27618452 27618447 19430483 ) Systolic blood pressure (cigarette smoking interaction) ( 29455858 ) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858 ) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858 ) Tuberculosis ( 29036319 )	No GWAS studies recorded
Novel Interactors		4 novel interactors: MTOR SLC45A1 SMARCA4 TNFRSF25	4 novel interactors: EIF2S2 NCOA7 NPPB SLC2A5
Interacting Genes		13 interacting genes: CYSRT1 EWSR1 GEMIN4 HDAC4 KRT40 KRTAP10-3 KRTAP10-9 NOTCH2NLA NPR1 NPR2 NPR3 PSMA3 SERTAD3	9 interacting genes: BAG4 DAP3 DYRK1A MAPK1 TNFRSF1A TNFSF12 TNFSF15 TRADD TRAF2
Entrez ID		4879	8718
HPRD ID		08974	04532
Ensembl ID		ENSG00000120937	ENSG00000215788
Uniprot IDs		P16860	Q93038
PDB IDs		1YK1 3N56	5YGP 5YGS
GO Terms Enriched among Interactors		Natriuretic Peptide Receptor Activity CGMP Biosynthetic Process Hormone Binding CGMP Metabolic Process Cyclic Nucleotide Biosynthetic Process Peptide Hormone Binding Cyclic Purine Nucleotide Metabolic Process Guanylate Cyclase Activity Positive Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Positive Regulation Of Urine Volume Receptor Guanylyl Cyclase Signaling Pathway Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Keratin Filament Phosphorus-oxygen Lyase Activity Regulation Of Urine Volume Purine Ribonucleotide Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase I Neuronal Action Potential Ribose Phosphate Biosynthetic Process Intermediate Filament Regulation Of Cell Growth Negative Regulation Of Cell Growth Regulation Of Blood Pressure Purine Nucleotide Biosynthetic Process G Protein-coupled Peptide Receptor Activity Regulation Of Myotube Differentiation Regulation Of Transcription By RNA Polymerase I Positive Regulation Of SCF-dependent Proteasomal Ubiquitin-dependent Catabolic Process Blood Circulation Nucleotide Biosynthetic Process ANPR-A Receptor Complex Vestibulocochlear Nerve Maturation Blood Vessel Remodeling D-glucose:proton Symporter Activity Galactose:proton Symporter Activity Regulation Of Glycolytic Process Negative Regulation Of Growth Purine-containing Compound Biosynthetic Process Cajal Body Regulation Of Locomotor Rhythm Regulation Of Carbohydrate Catabolic Process TFIIIC-class Transcription Factor Complex Binding Cumulus Cell Differentiation C-di-GMP Signaling Activation Of Meiosis Involved In Egg Activation Gastric Emptying Sucrose Transport Sucrose:proton Symporter Activity Nucleobase-containing Small Molecule Metabolic Process Regulation Of ATP Metabolic Process	Tumor Necrosis Factor Receptor Superfamily Complex Non-canonical NF-kappaB Signal Transduction Tumor Necrosis Factor Receptor Binding Apoptotic Signaling Pathway Tumor Necrosis Factor-mediated Signaling Pathway Tumor Necrosis Factor Binding Positive Regulation Of Extrinsic Apoptotic Signaling Pathway RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Programmed Cell Death Cell Death Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Cellular Response To Tumor Necrosis Factor Negative Regulation Of MRNA Metabolic Process Regulation Of Canonical NF-kappaB Signal Transduction Extrinsic Apoptotic Signaling Pathway Response To Tumor Necrosis Factor Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Apoptotic Signaling Pathway Cytokine-mediated Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Intracellular Signal Transduction Cell Surface Receptor Signaling Pathway Positive Regulation Of Inflammatory Response Intracellular Signaling Cassette Regulation Of Apoptotic Process Receptor Complex Regulation Of Programmed Cell Death Regulation Of Signal Transduction Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Histone H3T45 Kinase Activity Diuretic Hormone Activity Positive Regulation Of Protein Phosphorylation Response To Epidermal Growth Factor Fructose Import Across Plasma Membrane Positive Regulation Of Signal Transduction TORC2 Complex Disassembly Negative Regulation Of MRNA Modification Positive Regulation Of Phosphorylation Positive Regulation Of Intracellular Signal Transduction Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Phosphate Metabolic Process Cytosine Metabolic Process TRAF2-GSTP1 Complex TORC1 Complex Assembly