NPPB and KRTAP10-9

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		NPPB	KRTAP10-9
Description		natriuretic peptide B	keratin associated protein 10-9
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Protein-containing Complex	Cytosol Intermediate Filament Keratin Filament
	Molecular Function	Signaling Receptor Binding Hormone Activity Protein Binding Diuretic Hormone Activity Guanylate Cyclase Activator Activity Hormone Receptor Binding	Protein Binding
	Biological Process	System Process Negative Regulation Of Systemic Arterial Blood Pressure Cardiac Conduction System Development CGMP Biosynthetic Process Protein Folding Cell Surface Receptor Signaling Pathway Receptor Guanylyl Cyclase Signaling Pathway Neuropeptide Signaling Pathway Body Fluid Secretion Regulation Of Blood Pressure Negative Regulation Of Angiogenesis CGMP-mediated Signaling Negative Regulation Of Cell Growth Killing Of Cells Of Another Organism Positive Regulation Of Urine Volume Positive Regulation Of Renal Sodium Excretion Vasodilation Regulation Of Vascular Permeability Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Blood Vessel Diameter Maintenance
Pathways			Keratinization
Drugs		Carvedilol Oxymetholone
Diseases
GWAS		B-type natriuretic peptide levels ( 25561047 29237677) B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio ( 29237677) Blood pressure ( 21909110) Blood protein levels ( 30072576) Blood protein levels in cardiovascular risk ( 28369058) Diastolic blood pressure ( 27618452 28739976) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Hip index ( 34021172) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) N-terminal pro B-type natriuretic peptide levels ( 29237677) NT-proBNP levels in acute coronary syndrome ( 26908625) Pulse pressure ( 30578418) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962) Systolic blood pressure ( 28739976 27618452 27618447 19430483) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Tuberculosis ( 29036319)
Interacting Genes		13 interacting genes: CYSRT1 EWSR1 GEMIN4 HDAC4 KRT40 KRTAP10-3 KRTAP10-9 NOTCH2NLA NPR1 NPR2 NPR3 PSMA3 SERTAD3	239 interacting genes: ADAMTSL4 ALDH3B1 ALPI ANKS1A ARFGAP1 ATXN7L1 AVPI1 BCL6B BMP7 BRME1 C10orf62 C11orf87 C22orf39 CATIP CATSPER1 CBX2 CCDC26 CD300LG CDKL3 CHIC2 CHRD CHRNG CKS1B CLK4 CNNM3 CRCT1 CREB5 CST9L CXCL16 CYSRT1 DHRS1 DHX57 DMRT3 DOCK2 EIF4E2 EZH2 FAM124B FAM161A FAM74A4 FAM76B FARS2 FBXW5 GABARAPL1 GABARAPL2 GATA2 GLIDR GLP1R GLRX3 GNE GPATCH2L GSTP1 GUCD1 HBG1 HBZ HCK HES6 HOXA1 HOXB9 HOXC8 HPCAL1 HSBP1 HSD3B7 IGSF8 INPP5D IQUB ITGB4 ITGB5 KAT5 KIAA0040 KIF9 KLHL38 KRT20 KRT83 KRTAP1-1 KRTAP1-3 KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP12-1 KRTAP12-3 KRTAP26-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-11 KRTAP5-2 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-7 KRTAP5-9 KRTAP9-2 KRTAP9-3 KRTAP9-4 KRTAP9-8 LCE1A LCE1B LCE1C LCE1D LCE1E LCE1F LCE2A LCE2B LCE2C LCE2D LCE3A LCE3B LCE3C LCE3D LCE3E LCE4A LCE5A LUZP4 MAB21L3 MAPKBP1 MAZ MED30 MEOX2 MOBP MT1DP MXI1 MYPOP NAXD NBPF19 NECTIN3 NKD1 NOTCH2NLA NPBWR2 NPDC1 NPPB NR1D2 NUFIP2 OTX1 PCSK5 PDE9A PDGFRB PGAP2 PGLS PIGS PIN1 PLSCR1 POU4F2 PRKAA2 PRKAB2 PRPF31 PTGER3 PTPMT1 PVR RAB7A RASD1 RHNO1 RSPO2 SCARB1 SCNM1 SEMA3B SHFL SLC23A1 SLC6A20 SMARCE1 SMCP SPACA9 SPATA3 SPATA31J1 SPATA8 SPG7 SPRY1 SPRY2 STK16 TBC1D16 TBC1D23 TBC1D26 TEDC2 TGOLN2 THAP10 TLE5 TNFRSF6B TNP2 TRIM41 TRIM42 TXNDC5 TYMSOS TYRO3 UTP23 VGLL3 WNT11 WT1 WT1-AS XCL2 YIPF3 YY1 ZBTB24 ZBTB38 ZBTB9 ZFYVE26 ZNF124 ZNF155 ZNF165 ZNF20 ZNF251 ZNF264 ZNF275 ZNF286A ZNF317 ZNF319 ZNF417 ZNF433 ZNF439 ZNF440 ZNF473 ZNF490 ZNF491 ZNF497 ZNF524 ZNF564 ZNF572 ZNF578 ZNF581 ZNF587 ZNF599 ZNF625 ZNF688 ZNF696 ZNF697 ZNF699 ZNF764 ZNF774 ZNF777 ZNF792 ZNF80 ZNF837 ZNF844 ZNF860 ZSCAN21 ZSCAN26
Entrez ID		4879	386676
HPRD ID		08974	11195
Ensembl ID		ENSG00000120937	ENSG00000221837
Uniprot IDs		P16860	P60411
PDB IDs		1YK1 3N56
Enriched GO Terms of Interacting Partners?		Natriuretic Peptide Receptor Activity CGMP Biosynthetic Process Hormone Binding CGMP Metabolic Process Cyclic Nucleotide Biosynthetic Process Peptide Hormone Binding Cyclic Purine Nucleotide Metabolic Process Guanylate Cyclase Activity Positive Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Positive Regulation Of Urine Volume Receptor Guanylyl Cyclase Signaling Pathway Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Keratin Filament Phosphorus-oxygen Lyase Activity Regulation Of Urine Volume Purine Ribonucleotide Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase I Neuronal Action Potential Ribose Phosphate Biosynthetic Process Intermediate Filament Regulation Of Cell Growth Negative Regulation Of Cell Growth Regulation Of Blood Pressure Purine Nucleotide Biosynthetic Process G Protein-coupled Peptide Receptor Activity Regulation Of Myotube Differentiation Regulation Of Transcription By RNA Polymerase I Positive Regulation Of SCF-dependent Proteasomal Ubiquitin-dependent Catabolic Process Blood Circulation Nucleotide Biosynthetic Process ANPR-A Receptor Complex Vestibulocochlear Nerve Maturation Blood Vessel Remodeling D-glucose:proton Symporter Activity Galactose:proton Symporter Activity Regulation Of Glycolytic Process Negative Regulation Of Growth Purine-containing Compound Biosynthetic Process Cajal Body Regulation Of Locomotor Rhythm Regulation Of Carbohydrate Catabolic Process TFIIIC-class Transcription Factor Complex Binding Cumulus Cell Differentiation C-di-GMP Signaling Activation Of Meiosis Involved In Egg Activation Gastric Emptying Sucrose Transport Sucrose:proton Symporter Activity Nucleobase-containing Small Molecule Metabolic Process Regulation Of ATP Metabolic Process	Intermediate Filament Keratin Filament Keratinization Epidermis Development DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Transcription By RNA Polymerase II Zinc Ion Binding DNA Binding Hair Cycle Tissue Development Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Activity Lung Growth
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