NPPB

Gene Name		natriuretic peptide B
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Protein Complex
	Molecular Function	Receptor Binding Hormone Activity Diuretic Hormone Activity
	Biological Process	CGMP Biosynthetic Process Cell Surface Receptor Signaling Pathway Receptor Guanylyl Cyclase Signaling Pathway Body Fluid Secretion Regulation Of Blood Pressure Negative Regulation Of Angiogenesis Negative Regulation Of Cell Growth Positive Regulation Of Urine Volume Positive Regulation Of Renal Sodium Excretion Regulation Of Vasodilation Regulation Of Vascular Permeability Regulation Of Blood Vessel Size
Pathways
Drugs		Carvedilol
Diseases
GWAS		Blood pressure ( 21909110) Systolic blood pressure ( 19430483)
Protein-protein Interactions		10 interactors: EWSR1 HDAC4 KRT40 KRTAP10-3 KRTAP10-9 NOTCH2NL NPR1 NPR2 NPR3 PSMA3
Entrez ID		4879
HPRD ID		08974
Ensembl ID		ENSG00000120937
Uniprot IDs		P16860
PDB IDs		1YK1 3N56
Enriched GO Terms of Interacting Partners?		Receptor Guanylyl Cyclase Signaling Pathway Positive Regulation Of Urine Volume CGMP Biosynthetic Process Regulation Of Blood Pressure CGMP Metabolic Process Intracellular Signal Transduction Cyclic Purine Nucleotide Metabolic Process Negative Regulation Of Smooth Muscle Cell Proliferation Blood Circulation Cyclic Nucleotide Biosynthetic Process Cyclic Nucleotide Metabolic Process Renal System Process Regulation Of Smooth Muscle Cell Proliferation Body Fluid Secretion Skeletal System Development Signal Transduction Negative Regulation Of Cell Proliferation Negative Regulation Of Oocyte Maturation Signaling Purine Nucleotide Biosynthetic Process Ribose Phosphate Biosynthetic Process Cell Communication Negative Regulation Of Oocyte Development Osteoclast Proliferation Pancreatic Juice Secretion Negative Regulation Of Glycolytic Process Peptidyl-lysine Deacetylation Response To Denervation Involved In Regulation Of Muscle Adaptation Cellular Response To Stimulus Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus Ossification Response To Inactivity Ribonucleotide Metabolic Process Nucleotide Biosynthetic Process Purine Nucleotide Metabolic Process Ribose Phosphate Metabolic Process Negative Regulation Of Myotube Differentiation Positive Regulation Of Renal Sodium Excretion Positive Regulation Of Protein Sumoylation Positive Regulation Of CGMP Biosynthetic Process Regulation Of Skeletal Muscle Fiber Development Cardiac Muscle Hypertrophy In Response To Stress Positive Regulation Of Nitric-oxide Synthase Activity Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of CGMP Metabolic Process Regulation Of Protein Sumoylation Negative Regulation Of Striated Muscle Cell Differentiation Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Adenylate Cyclase Activity Regulation Of Renal Sodium Excretion
Tagcloud ?		0x10 18x10 75x10 americans ancestry architecture arr blacks bnp cardioprotective checked cogent consortium copies directions dosages echogen gwa imputed klkb1 logarithmically lvm motivate natriuretic relations residuals rs198389 rs3733402 whites