EPS15 and AP2A1

Number of citations of the paper that reports this interaction (PubMedID 9049247)
37

Data Source:
HPRD (in vivo, in vitro)

		EPS15	AP2A1
Description		epidermal growth factor receptor pathway substrate 15	adaptor related protein complex 2 subunit alpha 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane Clathrin-coated Pit Basal Plasma Membrane Membrane Aggresome Apical Plasma Membrane AP-2 Adaptor Complex Clathrin Coat Of Coated Pit Clathrin-coated Vesicle Early Endosome Membrane Synapse Ciliary Membrane Postsynaptic Endocytic Zone Glutamatergic Synapse	Cytosol Plasma Membrane Clathrin-coated Pit Synaptic Vesicle Cytoplasmic Side Of Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Membrane Coat AP-2 Adaptor Complex Clathrin Coat Of Trans-Golgi Network Vesicle Clathrin Adaptor Complex Clathrin-coated Vesicle Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Filopodium Tip Protein-containing Complex Endolysosome Membrane Clathrin-coated Endocytic Vesicle Postsynaptic Endocytic Zone Glutamatergic Synapse
	Molecular Function	Calcium Ion Binding Protein Binding SH3 Domain Binding Protein-macromolecule Adaptor Activity Polyubiquitin Modification-dependent Protein Binding Identical Protein Binding Ubiquitin Binding Cadherin Binding Metal Ion Binding	Protein Binding Protein Kinase Binding Clathrin Adaptor Activity Protein-containing Complex Binding Low-density Lipoprotein Particle Receptor Binding
	Biological Process	Positive Regulation Of Receptor Recycling Golgi To Endosome Transport Endocytosis Protein Transport Vesicle Organization Endosomal Transport Receptor-mediated Endocytosis Of Virus By Host Cell Endocytic Recycling Regulation Of Protein Localization Regulation Of Cell Population Proliferation Symbiont Entry Into Host Cell Clathrin Coat Assembly Ubiquitin-dependent Endocytosis Postsynaptic Neurotransmitter Receptor Internalization	Intracellular Protein Transport Golgi To Endosome Transport Endocytosis Positive Regulation Of Neuron Projection Development Protein Transport Vesicle-mediated Transport Positive Regulation Of Receptor-mediated Endocytosis Synaptic Vesicle Endocytosis Clathrin-dependent Endocytosis Postsynaptic Neurotransmitter Receptor Internalization Negative Regulation Of Hyaluronan Biosynthetic Process
Pathways		EGFR downregulation Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis InlB-mediated entry of Listeria monocytogenes into host cell Degradation of CDH1	Nef Mediated CD4 Down-regulation Retrograde neurotrophin signalling Retrograde neurotrophin signalling Nef Mediated CD8 Down-regulation MHC class II antigen presentation EPH-ephrin mediated repulsion of cells Trafficking of GluR2-containing AMPA receptors Recycling pathway of L1 Recycling pathway of L1 WNT5A-dependent internalization of FZD4 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis VLDLR internalisation and degradation LDL clearance Potential therapeutics for SARS
Drugs
Diseases
GWAS		Blood urea nitrogen levels ( 31152163) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Hip circumference adjusted for BMI ( 34021172) IgE grass sensitization ( 22036096) PR interval ( 30046033 32439900)	Appendicular lean mass ( 33097823)
Interacting Genes		62 interacting genes: AGFG1 AGFG2 AP1G1 AP2A1 AP2A2 CDC40 CLINT1 CORO7 CRK DLGAP5 DNM1 DNM2 DRAM1 EGFR ELF3 EPN1 EPN2 FCHO2 GRB2 HGS ITSN1 LAPTM5 LMTK3 MAPK14 MLLT10 MLLT6 MOB4 MTNR1A NAGPA NEDD4 NUMB NUMBL PALMD PICALM PRKN REPS2 RNF11 RNF26 SCAMP1 SH3BP4 SNAP91 SPART SPATA31E1 SPOPL STAM2 STAMBP STON2 SYNJ1 TC2N TFAP2A TMEM114 UBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2H UBQLN1 UBQLN3 USP8 WEE1	29 interacting genes: AP2S1 BIN1 CLINT1 DEK DNM2 DPYSL2 DSCAM DUX4 EHD1 EPN1 EPS15 GHR HIP1 NAGPA NUMB PICALM PIN1 PLK2 RAB11FIP2 RIT1 SHBG SHC1 SMAD9 SNAP29 SYNJ1 SYT3 SYT7 TOE1 UBC
Entrez ID		2060	160
HPRD ID		08968	03016
Ensembl ID		ENSG00000085832	ENSG00000196961
Uniprot IDs		A0A994J5A3 A0A994J5J3 B7Z240 P42566	O95782
PDB IDs		1C07 1EH2 1F8H 1FF1 2IV9 2JXC 4RH5 4RH9 4RHG 4S0G 5AWT 5AWU 5JP2
Enriched GO Terms of Interacting Partners?		Endocytosis Clathrin-coated Pit Import Into Cell Clathrin-coated Vesicle Receptor-mediated Endocytosis Vesicle-mediated Transport Clathrin-dependent Endocytosis Synaptic Vesicle Endocytosis Presynaptic Endocytosis Receptor Internalization Clathrin Coat Assembly Modification-dependent Protein Catabolic Process Vesicle Organization Vesicle-mediated Transport In Synapse Establishment Of Localization In Cell Endosome Vesicle Budding From Membrane Proteolysis Involved In Protein Catabolic Process Ubiquitin Conjugating Enzyme Activity Clathrin Binding Cytoplasmic Vesicle Clathrin Adaptor Activity Membrane Organization Cytosol Intracellular Vesicle Ubiquitin-dependent Protein Catabolic Process Protein Localization To Vacuole Post-translational Protein Modification Protein Ubiquitination Post-Golgi Vesicle-mediated Transport Protein Localization To Lysosome Vacuolar Transport Protein K48-linked Ubiquitination Establishment Of Protein Localization To Vacuole Membrane Coat Macromolecule Catabolic Process Clathrin Vesicle Coat Proteolysis Protein Targeting To Lysosome Cellular Localization Lysosomal Transport Negative Regulation Of Cellular Response To Growth Factor Stimulus Protein Modification By Small Protein Conjugation AP-2 Adaptor Complex Endocytic Vesicle Membrane Phosphatidylinositol-4,5-bisphosphate Binding Protein Polyubiquitination Synaptic Vesicle Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Catabolic Process	Endocytosis Import Into Cell Vesicle-mediated Transport Clathrin Binding Clathrin Coat Assembly Clathrin-coated Pit Clathrin-coated Vesicle Phospholipid Binding Receptor Internalization Clathrin Coat Of Coated Pit Vesicle-mediated Transport In Synapse Regulation Of Vesicle-mediated Transport Endosome Protein-containing Complex Assembly Phosphatidylinositol-4,5-bisphosphate Binding Ciliary Pocket Membrane Protein-containing Complex Organization Receptor-mediated Endocytosis Plasma Membrane Regulation Of Endocytosis Synaptic Vesicle Endocytosis Presynapse Presynaptic Endocytosis Regulation Of Amyloid-beta Formation Tau Protein Binding Cytoplasmic Vesicle Postsynaptic Neurotransmitter Receptor Internalization Endomembrane System Regulation Of Cellular Component Organization Regulation Of Amyloid Precursor Protein Catabolic Process Clathrin Vesicle Coat Ciliary Membrane Establishment Of Localization In Cell AP-2 Adaptor Complex Cytosol Establishment Of Protein Localization Vesicle Organization Cadherin Binding SNARE Binding Lipid Binding Endocytic Vesicle Membrane Cellular Component Assembly Glutamatergic Synapse Protein Transport Regulation Of Amide Metabolic Process Synaptic Vesicle Priming Membrane Clathrin Adaptor Activity Calcium Ion Sensor Activity Organelle Organization
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