EPS15 and DNM2

Number of citations of the paper that reports this interaction (PMID 11483962)
18

Data Source:
HPRD (in vitro, in vivo)

		EPS15	DNM2
Gene Name		epidermal growth factor receptor pathway substrate 15	dynamin 2
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Coated Pit Membrane AP-2 Adaptor Complex Early Endosome Membrane Intracellular Membrane-bounded Organelle Ciliary Membrane	Golgi Membrane Cytoplasm Golgi Apparatus Cytosol Microtubule Plasma Membrane Coated Pit Focal Adhesion Postsynaptic Density Growth Cone Midbody Endocytic Vesicle Membrane Postsynaptic Membrane Extracellular Vesicular Exosome
	Molecular Function	Calcium Ion Binding Protein Binding SH3 Domain Binding Polyubiquitin Binding Identical Protein Binding	GTPase Activity Protein Binding GTP Binding Microtubule Binding SH3 Domain Binding Enzyme Binding
	Biological Process	Golgi To Endosome Transport Endocytosis Epidermal Growth Factor Receptor Signaling Pathway Cell Proliferation Protein Transport Vesicle Organization Endocytic Recycling Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Clathrin Coat Assembly	G2/M Transition Of Mitotic Cell Cycle Regulation Of Transcription, DNA-templated Post-Golgi Vesicle-mediated Transport Endocytosis Receptor-mediated Endocytosis Signal Transduction Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Regulation Of Axon Extension Receptor Internalization Transferrin Transport Positive Regulation Of Apoptotic Process Small Molecule Metabolic Process Positive Regulation Of Transcription, DNA-templated Nitric Oxide Metabolic Process Synaptic Vesicle Transport Neuron Projection Morphogenesis Regulation Of Nitric-oxide Synthase Activity Membrane Organization Negative Regulation Of Membrane Tubulation
Pathways		Signaling by EGFR EGFR downregulation Signaling by EGFR in Cancer Signaling by Ligand-Responsive EGFR Variants in Cancer Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by EGFRvIII in Cancer	Retrograde neurotrophin signalling Axon guidance Gap junction degradation Golgi Associated Vesicle Biogenesis L1CAM interactions Recycling pathway of L1 Clathrin derived vesicle budding Lysosome Vesicle Biogenesis Metabolism of nitric oxide Gap junction trafficking and regulation NOSTRIN mediated eNOS trafficking MHC class II antigen presentation eNOS activation and regulation trans-Golgi Network Vesicle Budding Innate Immune System Formation of annular gap junctions Signalling by NGF Gap junction trafficking NGF signalling via TRKA from the plasma membrane Toll-Like Receptors Cascades Toll Like Receptor 4 (TLR4) Cascade Adaptive Immune System
Drugs
Diseases
GWAS		IgE grass sensitization ( 22036096)	Coronary heart disease ( 21347282)
Protein-Protein Interactions		42 interactors: AGFG1 AGFG2 AP2A1 AP2A2 CLINT1 CORO7 CRK DNM1 DNM2 EGFR ELF3 EPN1 EPN2 GRB2 HGS ITSN1 ITSN2 LAPTM5 MOB4 NAGPA NEDD4 NUMB NUMBL OPTN PARK2 REPS2 RNF11 SCAMP1 SNAP91 SPG20 STAM2 STAMBP STON2 SYNJ1 TFAP2A UBB UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2H UBQLN1	52 interactors: AMPH AOC1 AP2A1 APP ATF7IP ATXN3 BIN1 CCDC90B CCR5 CCT7 CDK1 CTTN DDX39B DNM1 DYNC1I1 DYNLL1 EIF3L EPS15 FNBP1 FNBP1L GDF9 GRB2 HCK HMGB1 ITSN1 ITSN2 KDR MAN1B1 MANEA MPHOSPH6 MPP6 PDE6G PFN1 PPIB PSTPIP1 PTK2 RPS2 RWDD2B SH3GL2 SH3GLB1 SHANK1 SHANK2 SNX9 SPRY2 SRC TIAM2 TRIP10 TYK2 VAV1 WBP4 ZBTB16 ZFAND6
Entrez ID		2060	1785
HPRD ID		08968	03852
Ensembl ID		ENSG00000085832	ENSG00000079805
Uniprot IDs		B1AUU8 B7Z240 H7BYP0 P42566	P50570 Q8N1K8
PDB IDs		1C07 1EH2 1F8H 1FF1 2IV9 2JXC	2YS1
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Endocytosis Vesicle-mediated Transport Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Protein K48-linked Ubiquitination Enzyme Linked Receptor Protein Signaling Pathway Negative Regulation Of Signal Transduction Protein Polyubiquitination Negative Regulation Of Signaling Regulation Of Signal Transduction Regulation Of Signaling Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Signaling Cell Communication Transport Post-Golgi Vesicle-mediated Transport Cellular Localization Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Neuron Development Neurotrophin TRK Receptor Signaling Pathway Neuron Projection Development Establishment Of Localization In Cell Neuron Projection Morphogenesis Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Neurotrophin Signaling Pathway Intracellular Transport Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Neuron Differentiation Cell Surface Receptor Signaling Pathway Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Ubiquitination Cellular Response To Growth Factor Stimulus Establishment Of Protein Localization Response To Growth Factor Regulation Of Intracellular Signal Transduction Ephrin Receptor Signaling Pathway Protein Modification By Small Protein Conjugation Cellular Response To Hypoxia Protein Monoubiquitination Protein Catabolic Process Cellular Response To Decreased Oxygen Levels Receptor Internalization Protein Targeting To Lysosome	Endocytosis Vesicle-mediated Transport Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cellular Response To Growth Factor Stimulus Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Response To Growth Factor Regulation Of ERBB Signaling Pathway Movement Of Cell Or Subcellular Component Locomotion Cellular Response To Organic Substance Chemotaxis Cellular Localization Regulation Of Signal Transduction Regulation Of Signaling Transport Neurotrophin TRK Receptor Signaling Pathway Viral Process Positive Regulation Of Cellular Component Biogenesis Peptidyl-tyrosine Autophosphorylation Neurotrophin Signaling Pathway Regulation Of Apoptotic Process Regulation Of Protein Complex Assembly Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Establishment Of Localization In Cell Regulation Of Cell Death Negative Regulation Of ERBB Signaling Pathway Neuron Projection Morphogenesis Positive Regulation Of Protein Complex Assembly Neuron Projection Development Axon Guidance Cell Projection Morphogenesis Cell Part Morphogenesis Regulation Of Cellular Component Organization Cell Morphogenesis Involved In Neuron Differentiation Positive Regulation Of Catalytic Activity Response To Organic Substance Nervous System Development Neuron Development Cell Projection Organization Response To External Stimulus Apoptotic Process Cellular Component Assembly Programmed Cell Death Cell Migration Immune System Process Axonogenesis Cell Death
Tagcloud ?		6g4 adaptin adaptins ap cerevisiae clathrin coimmunoprecipitated delineated end3 endocytosis glutathione homology immunoprecipitates immunoreactivity kd keeping mammals metabolically mu2 nh2 nih3t3 pheromone polypeptides precipitated saccharomyces sets sigma transferase ubiquitous	bcl11b cadherin discovered druggable exhibitedthe fat1 fbxw7 frequencies guide harboured herc1 jak jak3 lymphoblastic mll2 mutational notch1 notch2 phf6 recurrent regulators reln secretase splicing subclonal unfavourable warranted wt1 zrsr2
Tagcloud (Difference) ?		6g4 adaptin adaptins ap cerevisiae clathrin coimmunoprecipitated delineated end3 endocytosis glutathione homology immunoprecipitates immunoreactivity kd keeping mammals metabolically mu2 nh2 nih3t3 pheromone polypeptides precipitated saccharomyces sets sigma transferase ubiquitous	bcl11b cadherin discovered druggable exhibitedthe fat1 fbxw7 frequencies guide harboured herc1 jak jak3 lymphoblastic mll2 mutational notch1 notch2 phf6 recurrent regulators reln secretase splicing subclonal unfavourable warranted wt1 zrsr2
Tagcloud (Intersection) ?