Wiki-Pi
About
Search
People
Updates
Search
EPS15 and NUMB
Number of citations of the paper that reports this interaction (PubMedID
37219487
)
66
Data Source:
BioGRID
(unspecified method, affinity chromatography technology)
HPRD
(in vitro, in vivo)
EPS15
NUMB
Description
epidermal growth factor receptor pathway substrate 15
NUMB endocytic adaptor protein
Image
GO Annotations
Cellular Component
Cytoplasm
Endosome
Early Endosome
Cytosol
Plasma Membrane
Clathrin-coated Pit
Basal Plasma Membrane
Membrane
Aggresome
Apical Plasma Membrane
AP-2 Adaptor Complex
Clathrin Coat Of Coated Pit
Clathrin-coated Vesicle
Early Endosome Membrane
Synapse
Ciliary Membrane
Postsynaptic Endocytic Zone
Glutamatergic Synapse
Cytoplasm
Endosome
Early Endosome
Plasma Membrane
Clathrin-coated Pit
Focal Adhesion
Endosome Membrane
Membrane
Basolateral Plasma Membrane
Clathrin-coated Vesicle
Cytoplasmic Vesicle
Apical Part Of Cell
Glutamatergic Synapse
Molecular Function
Calcium Ion Binding
Protein Binding
SH3 Domain Binding
Protein-macromolecule Adaptor Activity
Polyubiquitin Modification-dependent Protein Binding
Identical Protein Binding
Ubiquitin Binding
Cadherin Binding
Metal Ion Binding
Protein Binding
Beta-catenin Binding
Alpha-catenin Binding
Cadherin Binding
Biological Process
Positive Regulation Of Receptor Recycling
Golgi To Endosome Transport
Endocytosis
Protein Transport
Vesicle Organization
Endosomal Transport
Receptor-mediated Endocytosis Of Virus By Host Cell
Endocytic Recycling
Regulation Of Protein Localization
Regulation Of Cell Population Proliferation
Symbiont Entry Into Host Cell
Clathrin Coat Assembly
Ubiquitin-dependent Endocytosis
Postsynaptic Neurotransmitter Receptor Internalization
Nervous System Development
Neuroblast Proliferation
Axonogenesis
Lateral Ventricle Development
Neuroblast Division In Subventricular Zone
Positive Regulation Of Cell Migration
Forebrain Development
Adherens Junction Organization
Positive Regulation Of Neurogenesis
Regulation Of Postsynaptic Neurotransmitter Receptor Internalization
Negative Regulation Of Protein Localization To Plasma Membrane
Pathways
EGFR downregulation
Negative regulation of MET activity
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
InlB-mediated entry of Listeria monocytogenes into host cell
Degradation of CDH1
Activated NOTCH1 Transmits Signal to the Nucleus
Recycling pathway of L1
Degradation of GLI1 by the proteasome
Hedgehog 'on' state
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin
Drugs
Diseases
GWAS
Blood urea nitrogen levels (
31152163
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Hip circumference adjusted for BMI (
34021172
)
IgE grass sensitization (
22036096
)
PR interval (
30046033
32439900
)
Bipolar disorder with mood-incongruent psychosis (
23092984
)
Coronary artery calcification (
17903303
)
Hemoglobin (
32888494
)
Macular thickness (
30535121
)
Multisite chronic pain (
31194737
33830993
)
White matter hyperintensity volume x hypertension interaction (2df) (
33293549
)
Interacting Genes
62 interacting genes:
AGFG1
AGFG2
AP1G1
AP2A1
AP2A2
CDC40
CLINT1
CORO7
CRK
DLGAP5
DNM1
DNM2
DRAM1
EGFR
ELF3
EPN1
EPN2
FCHO2
GRB2
HGS
ITSN1
LAPTM5
LMTK3
MAPK14
MLLT10
MLLT6
MOB4
MTNR1A
NAGPA
NEDD4
NUMB
NUMBL
PALMD
PICALM
PRKN
REPS2
RNF11
RNF26
SCAMP1
SH3BP4
SNAP91
SPART
SPATA31E1
SPOPL
STAM2
STAMBP
STON2
SYNJ1
TC2N
TFAP2A
TMEM114
UBB
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2E1
UBE2H
UBQLN1
UBQLN3
USP8
WEE1
38 interacting genes:
AP2A1
AP2A2
APP
DPYSL2
EAF1
EGFR
EPS15
FBXO7
FRS3
IQGAP1
IRS1
ITCH
ITGB2
ITGB3
ITGB5
L1CAM
LNX1
LNX2
MAPK8IP2
MDM2
NEDD4
NOTCH1
NRON
OLIG1
PALS1
PDZK1IP1
PRKCA
PRKCB
PRKCD
PRKCE
PRKCG
PRKCH
PRKCZ
PTEN
RPL3
SIAH1
SPANXN2
TERF2
Entrez ID
2060
8650
HPRD ID
08968
04767
Ensembl ID
ENSG00000085832
ENSG00000133961
Uniprot IDs
A0A994J5A3
A0A994J5J3
B7Z240
P42566
P49757
PDB IDs
1C07
1EH2
1F8H
1FF1
2IV9
2JXC
4RH5
4RH9
4RHG
4S0G
5AWT
5AWU
5JP2
5NJJ
5NJK
Enriched GO Terms of Interacting Partners
?
Endocytosis
Clathrin-coated Pit
Import Into Cell
Clathrin-coated Vesicle
Receptor-mediated Endocytosis
Vesicle-mediated Transport
Clathrin-dependent Endocytosis
Synaptic Vesicle Endocytosis
Presynaptic Endocytosis
Receptor Internalization
Clathrin Coat Assembly
Modification-dependent Protein Catabolic Process
Vesicle Organization
Vesicle-mediated Transport In Synapse
Establishment Of Localization In Cell
Endosome
Vesicle Budding From Membrane
Proteolysis Involved In Protein Catabolic Process
Ubiquitin Conjugating Enzyme Activity
Clathrin Binding
Cytoplasmic Vesicle
Clathrin Adaptor Activity
Membrane Organization
Cytosol
Intracellular Vesicle
Ubiquitin-dependent Protein Catabolic Process
Protein Localization To Vacuole
Post-translational Protein Modification
Protein Ubiquitination
Post-Golgi Vesicle-mediated Transport
Protein Localization To Lysosome
Vacuolar Transport
Protein K48-linked Ubiquitination
Establishment Of Protein Localization To Vacuole
Membrane Coat
Macromolecule Catabolic Process
Clathrin Vesicle Coat
Proteolysis
Protein Targeting To Lysosome
Cellular Localization
Lysosomal Transport
Negative Regulation Of Cellular Response To Growth Factor Stimulus
Protein Modification By Small Protein Conjugation
AP-2 Adaptor Complex
Endocytic Vesicle Membrane
Phosphatidylinositol-4,5-bisphosphate Binding
Protein Polyubiquitination
Synaptic Vesicle
Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway
Catabolic Process
Diacylglycerol-dependent Serine/threonine Kinase Activity
Enzyme Binding
Plasma Membrane
Receptor Internalization
Positive Regulation Of Signaling
Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity
Protein Kinase C Signaling
Diacylglycerol-dependent, Calcium-independent Serine/threonine Kinase Activity
Protein-containing Complex
Positive Regulation Of Cell Communication
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Intracellular Signal Transduction
Apical Plasma Membrane
Positive Regulation Of Signal Transduction
Positive Regulation Of Superoxide Anion Generation
Regulation Of Superoxide Anion Generation
Regulation Of MAPK Cascade
Negative Regulation Of Apoptotic Process
Regulation Of Protein Localization
Regulation Of Signaling
Negative Regulation Of Programmed Cell Death
Endocytosis
Intracellular Signal Transduction
Regulation Of Biological Quality
Regulation Of Superoxide Metabolic Process
Postsynaptic Neurotransmitter Receptor Internalization
Positive Regulation Of MAPK Cascade
Regulation Of Apoptotic Process
Regulation Of Signal Transduction
Cell Activation
Negative Regulation Of Glial Cell Apoptotic Process
Ubiquitin-protein Transferase Activity
Regulation Of Cellular Component Organization
Regulation Of Programmed Cell Death
AP-2 Adaptor Complex
Positive Regulation Of Metabolic Process
Regulation Of Cell Communication
Receptor-mediated Endocytosis
Regulation Of Vesicle-mediated Transport
Apoptotic Process
Positive Regulation Of Catabolic Process
Extracellular Exosome
Signal Transduction
Positive Regulation Of ERK1 And ERK2 Cascade
Regulation Of Transport
Programmed Cell Death
Cell Death
Negative Regulation Of Insulin Receptor Signaling Pathway
Modulation Of Excitatory Postsynaptic Potential
Negative Regulation Of Cellular Response To Insulin Stimulus
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?