EPS15 and STAM2

Number of citations of the paper that reports this interaction (PubMedID 12551915)
0

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		EPS15	STAM2
Description		epidermal growth factor receptor pathway substrate 15	signal transducing adaptor molecule 2
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GO Annotations	Cellular Component	Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane Clathrin-coated Pit Basal Plasma Membrane Membrane Aggresome Apical Plasma Membrane AP-2 Adaptor Complex Clathrin Coat Of Coated Pit Clathrin-coated Vesicle Early Endosome Membrane Synapse Ciliary Membrane Postsynaptic Endocytic Zone Glutamatergic Synapse	Nucleoplasm Cytoplasm Endosome Cytosol Membrane Endocytic Vesicle Early Endosome Membrane ESCRT-0 Complex
	Molecular Function	Calcium Ion Binding Protein Binding SH3 Domain Binding Protein-macromolecule Adaptor Activity Polyubiquitin Modification-dependent Protein Binding Identical Protein Binding Ubiquitin Binding Cadherin Binding Metal Ion Binding	Protein Binding Phosphatidylinositol Binding Ubiquitin Binding
	Biological Process	Positive Regulation Of Receptor Recycling Golgi To Endosome Transport Endocytosis Protein Transport Vesicle Organization Endosomal Transport Receptor-mediated Endocytosis Of Virus By Host Cell Endocytic Recycling Regulation Of Protein Localization Regulation Of Cell Population Proliferation Symbiont Entry Into Host Cell Clathrin Coat Assembly Ubiquitin-dependent Endocytosis Postsynaptic Neurotransmitter Receptor Internalization	Signal Transduction Protein Transport Macroautophagy Multivesicular Body Assembly Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Membrane Fission
Pathways		EGFR downregulation Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis InlB-mediated entry of Listeria monocytogenes into host cell Degradation of CDH1	EGFR downregulation Ub-specific processing proteases Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis InlB-mediated entry of Listeria monocytogenes into host cell RHOU GTPase cycle Endosomal Sorting Complex Required For Transport (ESCRT)
Drugs
Diseases
GWAS		Blood urea nitrogen levels ( 31152163) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Hip circumference adjusted for BMI ( 34021172) IgE grass sensitization ( 22036096) PR interval ( 30046033 32439900)	Adverse response to chemotherapy in breast cancer (alopecia) ( 24025145) Metabolic syndrome ( 31170924) Pulse pressure ( 30224653)
Interacting Genes		62 interacting genes: AGFG1 AGFG2 AP1G1 AP2A1 AP2A2 CDC40 CLINT1 CORO7 CRK DLGAP5 DNM1 DNM2 DRAM1 EGFR ELF3 EPN1 EPN2 FCHO2 GRB2 HGS ITSN1 LAPTM5 LMTK3 MAPK14 MLLT10 MLLT6 MOB4 MTNR1A NAGPA NEDD4 NUMB NUMBL PALMD PICALM PRKN REPS2 RNF11 RNF26 SCAMP1 SH3BP4 SNAP91 SPART SPATA31E1 SPOPL STAM2 STAMBP STON2 SYNJ1 TC2N TFAP2A TMEM114 UBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2H UBQLN1 UBQLN3 USP8 WEE1	37 interacting genes: ABI2 ARRDC3 ATXN1 CBX5 CDC7 DAZAP2 EGFR ENTREP1 EPS15 HGS ITCH JAK1 JAK2 JAK3 KLHL42 L3MBTL2 LCP2 LITAF MAP3K1 PHF10 PLEKHB2 PTPN1 RNF11 SH2D4A STAMBP TIMM8A TYK2 UBE2D1 UBE2D2 UBE2D3 UBE2H UBQLN1 UBQLN4 USP8 VPS37C XRN1 ZC3H10
Entrez ID		2060	10254
HPRD ID		08968	05876
Ensembl ID		ENSG00000085832	ENSG00000115145
Uniprot IDs		A0A994J5A3 A0A994J5J3 B7Z240 P42566	O75886
PDB IDs		1C07 1EH2 1F8H 1FF1 2IV9 2JXC 4RH5 4RH9 4RHG 4S0G 5AWT 5AWU 5JP2	1X2Q 1X5B 2L0T 5CRV 5IXF
Enriched GO Terms of Interacting Partners?		Endocytosis Clathrin-coated Pit Import Into Cell Clathrin-coated Vesicle Receptor-mediated Endocytosis Vesicle-mediated Transport Clathrin-dependent Endocytosis Synaptic Vesicle Endocytosis Presynaptic Endocytosis Receptor Internalization Clathrin Coat Assembly Modification-dependent Protein Catabolic Process Vesicle Organization Vesicle-mediated Transport In Synapse Establishment Of Localization In Cell Endosome Vesicle Budding From Membrane Proteolysis Involved In Protein Catabolic Process Ubiquitin Conjugating Enzyme Activity Clathrin Binding Cytoplasmic Vesicle Clathrin Adaptor Activity Membrane Organization Cytosol Intracellular Vesicle Ubiquitin-dependent Protein Catabolic Process Protein Localization To Vacuole Post-translational Protein Modification Protein Ubiquitination Post-Golgi Vesicle-mediated Transport Protein Localization To Lysosome Vacuolar Transport Protein K48-linked Ubiquitination Establishment Of Protein Localization To Vacuole Membrane Coat Macromolecule Catabolic Process Clathrin Vesicle Coat Proteolysis Protein Targeting To Lysosome Cellular Localization Lysosomal Transport Negative Regulation Of Cellular Response To Growth Factor Stimulus Protein Modification By Small Protein Conjugation AP-2 Adaptor Complex Endocytic Vesicle Membrane Phosphatidylinositol-4,5-bisphosphate Binding Protein Polyubiquitination Synaptic Vesicle Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Catabolic Process	Endosome Growth Hormone Receptor Signaling Pathway Via JAK-STAT Growth Hormone Receptor Signaling Pathway Growth Hormone Receptor Binding Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Modification Process Proteolysis Involved In Protein Catabolic Process Cell Surface Receptor Signaling Pathway Via JAK-STAT Early Endosome Proteolysis Cell Surface Receptor Signaling Pathway Via STAT Extrinsic Component Of Plasma Membrane Ubiquitin Conjugating Enzyme Activity Macromolecule Catabolic Process Protein Metabolic Process Non-membrane Spanning Protein Tyrosine Kinase Activity Protein K48-linked Ubiquitination Protein-containing Complex Cytoplasmic Side Of Plasma Membrane Negative Regulation Of Signal Transduction Early Endosome Membrane Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Type II Interferon-mediated Signaling Pathway Regulation Of Primary Metabolic Process Regulation Of Protein Modification Process Negative Regulation Of Cell Communication Protein Tyrosine Kinase Activity Negative Regulation Of Signaling Post-translational Protein Modification Regulation Of Macromolecule Metabolic Process Regulation Of Protein Metabolic Process Interleukin-12 Receptor Complex Ubiquitin-protein Transferase Activity Protein Autoubiquitination Receptor Internalization Regulation Of Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Macromolecule Metabolic Process Catabolic Process Interleukin-23 Receptor Complex Cytosol Protein Polyubiquitination Endosome Membrane Regulation Of Metabolic Process Enzyme-linked Receptor Protein Signaling Pathway Proteasomal Protein Catabolic Process Interleukin-23-mediated Signaling Pathway Positive Regulation Of NK T Cell Proliferation CXCL12-activated CXCR4 Signaling Pathway
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