EPS15 and STAM2

Number of citations of the paper that reports this interaction (PMID 12551915)
84

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		EPS15	STAM2
Gene Name		epidermal growth factor receptor pathway substrate 15	signal transducing adaptor molecule (SH3 domain and ITAM motif) 2
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Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Coated Pit Membrane AP-2 Adaptor Complex Early Endosome Membrane Intracellular Membrane-bounded Organelle Ciliary Membrane	Nucleoplasm Cytoplasm Cytosol Early Endosome Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Calcium Ion Binding Protein Binding SH3 Domain Binding Polyubiquitin Binding Identical Protein Binding	Protein Binding
	Biological Process	Golgi To Endosome Transport Endocytosis Epidermal Growth Factor Receptor Signaling Pathway Cell Proliferation Protein Transport Vesicle Organization Endocytic Recycling Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Clathrin Coat Assembly	Intracellular Protein Transport Epidermal Growth Factor Receptor Signaling Pathway Endosomal Transport Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Membrane Organization
Pathways		Signaling by EGFR EGFR downregulation Signaling by EGFR in Cancer Signaling by Ligand-Responsive EGFR Variants in Cancer Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by EGFRvIII in Cancer	Signaling by EGFR EGFR downregulation Endosomal Sorting Complex Required For Transport (ESCRT) Signaling by EGFR in Cancer Signaling by Ligand-Responsive EGFR Variants in Cancer Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by EGFRvIII in Cancer
Drugs
Diseases
GWAS		IgE grass sensitization ( 22036096)
Protein-Protein Interactions		42 interactors: AGFG1 AGFG2 AP2A1 AP2A2 CLINT1 CORO7 CRK DNM1 DNM2 EGFR ELF3 EPN1 EPN2 GRB2 HGS ITSN1 ITSN2 LAPTM5 MOB4 NAGPA NEDD4 NUMB NUMBL OPTN PARK2 REPS2 RNF11 SCAMP1 SNAP91 SPG20 STAM2 STAMBP STON2 SYNJ1 TFAP2A UBB UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2H UBQLN1	34 interactors: ABI2 ARRDC3 ATXN1 CBX5 DAZAP2 EGFR EPS15 FAM189A2 HGS ITCH JAK1 JAK2 JAK3 KLHL42 L3MBTL2 LCP2 LITAF PHF10 PLEKHB2 PTPN1 RNF11 SH2D4A STAMBP TIMM8A TYK2 UBC UBE2D1 UBE2D2 UBE2D3 UBE2H UBQLN4 USP8 VPS37C XRN1
Entrez ID		2060	10254
HPRD ID		08968	05876
Ensembl ID		ENSG00000085832	ENSG00000115145
Uniprot IDs		B1AUU8 B7Z240 H7BYP0 P42566	O75886
PDB IDs		1C07 1EH2 1F8H 1FF1 2IV9 2JXC	1X2Q 1X5B 2L0T
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Endocytosis Vesicle-mediated Transport Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Protein K48-linked Ubiquitination Enzyme Linked Receptor Protein Signaling Pathway Negative Regulation Of Signal Transduction Protein Polyubiquitination Negative Regulation Of Signaling Regulation Of Signal Transduction Regulation Of Signaling Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Signaling Cell Communication Transport Post-Golgi Vesicle-mediated Transport Cellular Localization Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Neuron Development Neurotrophin TRK Receptor Signaling Pathway Neuron Projection Development Establishment Of Localization In Cell Neuron Projection Morphogenesis Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Neurotrophin Signaling Pathway Intracellular Transport Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Neuron Differentiation Cell Surface Receptor Signaling Pathway Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Ubiquitination Cellular Response To Growth Factor Stimulus Establishment Of Protein Localization Response To Growth Factor Regulation Of Intracellular Signal Transduction Ephrin Receptor Signaling Pathway Protein Modification By Small Protein Conjugation Cellular Response To Hypoxia Protein Monoubiquitination Protein Catabolic Process Cellular Response To Decreased Oxygen Levels Receptor Internalization Protein Targeting To Lysosome	Regulation Of Innate Immune Response Innate Immune Response Regulation Of Immune Response Enzyme Linked Receptor Protein Signaling Pathway Protein K48-linked Ubiquitination Protein Polyubiquitination Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Protein Catabolic Process Immune Response Regulation Of Immune System Process Defense Response Protein Catabolic Process Cellular Macromolecule Catabolic Process Cellular Protein Modification Process Peptidyl-tyrosine Autophosphorylation Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Regulation Of Protein Catabolic Process Protein Ubiquitination Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress JAK-STAT Cascade Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Regulation Of DNA-templated Transcription In Response To Stress Protein Modification By Small Protein Conjugation Activation Of Innate Immune Response Cellular Protein Metabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Immune Response-regulating Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Interferon-gamma-mediated Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Regulation Of Response To Interferon-gamma Toll-like Receptor 4 Signaling Pathway Regulation Of Signal Transduction Regulation Of ERBB Signaling Pathway Positive Regulation Of Innate Immune Response Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Negative Regulation Of Signal Transduction Protein Autophosphorylation Regulation Of Cytokine-mediated Signaling Pathway Cellular Response To Hypoxia
Tagcloud ?		6g4 adaptin adaptins ap cerevisiae clathrin coimmunoprecipitated delineated end3 endocytosis glutathione homology immunoprecipitates immunoreactivity kd keeping mammals metabolically mu2 nh2 nih3t3 pheromone polypeptides precipitated saccharomyces sets sigma transferase ubiquitous	adaptors coimmunoprecipitated comprises dok1 epcs epo epor erythroblast erythroblasts gab1 hemoglobinizing homo irs2 orf phosphoproteomics phosphotyrosine primates propagates py rhex sapiens sh2d2a shc1 sprouty spry1 spry2 transducing ut7epo validating
Tagcloud (Difference) ?		6g4 adaptin adaptins ap cerevisiae clathrin delineated end3 endocytosis glutathione homology immunoprecipitates immunoreactivity kd keeping mammals metabolically mu2 nh2 nih3t3 pheromone polypeptides precipitated saccharomyces sets sigma transferase ubiquitous	adaptors comprises dok1 epcs epo epor erythroblast erythroblasts gab1 hemoglobinizing homo irs2 orf phosphoproteomics phosphotyrosine primates propagates py rhex sapiens sh2d2a shc1 sprouty spry1 spry2 transducing ut7epo validating
Tagcloud (Intersection) ?		coimmunoprecipitated