EPS15 and CLINT1

Number of citations of the paper that reports this interaction (PMID 12429846)
33

Data Source:
BioGRID (pull down)

		EPS15	CLINT1
Gene Name		epidermal growth factor receptor pathway substrate 15	clathrin interactor 1
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Coated Pit Membrane AP-2 Adaptor Complex Early Endosome Membrane Intracellular Membrane-bounded Organelle Ciliary Membrane	Nucleoplasm Golgi Apparatus Cytosol Membrane Clathrin-coated Vesicle Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm
	Molecular Function	Calcium Ion Binding Protein Binding SH3 Domain Binding Polyubiquitin Binding Identical Protein Binding	Protein Binding Lipid Binding Clathrin Binding
	Biological Process	Golgi To Endosome Transport Endocytosis Epidermal Growth Factor Receptor Signaling Pathway Cell Proliferation Protein Transport Vesicle Organization Endocytic Recycling Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Clathrin Coat Assembly	Post-Golgi Vesicle-mediated Transport Endocytosis Clathrin Coat Assembly Membrane Organization
Pathways		Signaling by EGFR EGFR downregulation Signaling by EGFR in Cancer Signaling by Ligand-Responsive EGFR Variants in Cancer Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by EGFRvIII in Cancer	Golgi Associated Vesicle Biogenesis trans-Golgi Network Vesicle Budding Clathrin derived vesicle budding
Drugs
Diseases
GWAS		IgE grass sensitization ( 22036096)
Protein-Protein Interactions		42 interactors: AGFG1 AGFG2 AP2A1 AP2A2 CLINT1 CORO7 CRK DNM1 DNM2 EGFR ELF3 EPN1 EPN2 GRB2 HGS ITSN1 ITSN2 LAPTM5 MOB4 NAGPA NEDD4 NUMB NUMBL OPTN PARK2 REPS2 RNF11 SCAMP1 SNAP91 SPG20 STAM2 STAMBP STON2 SYNJ1 TFAP2A UBB UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2H UBQLN1	12 interactors: AP1G1 AP2A1 AP2B1 CALM1 CLTC DNM1 EPS15 GGA1 GGA2 GGA3 JUN YWHAG
Entrez ID		2060	9685
HPRD ID		08968	06273
Ensembl ID		ENSG00000085832	ENSG00000113282
Uniprot IDs		B1AUU8 B7Z240 H7BYP0 P42566	Q14677
PDB IDs		1C07 1EH2 1F8H 1FF1 2IV9 2JXC	1XGW 2QY7 2V8S
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Endocytosis Vesicle-mediated Transport Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Protein K48-linked Ubiquitination Enzyme Linked Receptor Protein Signaling Pathway Negative Regulation Of Signal Transduction Protein Polyubiquitination Negative Regulation Of Signaling Regulation Of Signal Transduction Regulation Of Signaling Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Signaling Cell Communication Transport Post-Golgi Vesicle-mediated Transport Cellular Localization Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Neuron Development Neurotrophin TRK Receptor Signaling Pathway Neuron Projection Development Establishment Of Localization In Cell Neuron Projection Morphogenesis Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Neurotrophin Signaling Pathway Intracellular Transport Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Neuron Differentiation Cell Surface Receptor Signaling Pathway Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Ubiquitination Cellular Response To Growth Factor Stimulus Establishment Of Protein Localization Response To Growth Factor Regulation Of Intracellular Signal Transduction Ephrin Receptor Signaling Pathway Protein Modification By Small Protein Conjugation Cellular Response To Hypoxia Protein Monoubiquitination Protein Catabolic Process Cellular Response To Decreased Oxygen Levels Receptor Internalization Protein Targeting To Lysosome	Establishment Of Localization In Cell Protein Transport Intracellular Protein Transport Vesicle-mediated Transport Establishment Of Protein Localization Intracellular Transport Cellular Localization Protein Localization Cellular Protein Localization Transport Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Post-Golgi Vesicle-mediated Transport Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Regulation Of Defense Response To Virus By Virus Negative Regulation Of Hyaluronan Biosynthetic Process Clathrin-mediated Endocytosis Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Antigen Processing And Presentation Of Peptide Antigen Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Golgi Vesicle Transport Regulation Of ERBB Signaling Pathway Regulation Of Defense Response To Virus Antigen Processing And Presentation Endocytosis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Ephrin Receptor Signaling Pathway Receptor-mediated Endocytosis Golgi To Endosome Transport Membrane Organization Regulation Of Protein Autophosphorylation Response To External Stimulus Endosomal Transport Axon Development Cellular Response To Growth Factor Stimulus Neurotrophin TRK Receptor Signaling Pathway Response To Growth Factor Neurotrophin Signaling Pathway Receptor Internalization Regulation Of Immune System Process Cytoplasmic Transport Organelle Organization Immune System Process Nervous System Development Negative Regulation Of Protein Phosphorylation Cell Differentiation
Tagcloud ?		6g4 adaptin adaptins ap cerevisiae clathrin coimmunoprecipitated delineated end3 endocytosis glutathione homology immunoprecipitates immunoreactivity kd keeping mammals metabolically mu2 nh2 nih3t3 pheromone polypeptides precipitated saccharomyces sets sigma transferase ubiquitous	02mum 13mum 29ml aps consolidated cyp1a2 cyp2b6 cyp2c19 cyp2c8 cyp3a4 cyp450 dpa formations hlms invitro1 isozyme ketoconazole khellactone km1 m4 m5 m6 menten metabolisms michaelis naphthoflavone praeruptorin pyranocoumarins uhplc
Tagcloud (Difference) ?		6g4 adaptin adaptins ap cerevisiae clathrin coimmunoprecipitated delineated end3 endocytosis glutathione homology immunoprecipitates immunoreactivity kd keeping mammals metabolically mu2 nh2 nih3t3 pheromone polypeptides precipitated saccharomyces sets sigma transferase ubiquitous	02mum 13mum 29ml aps consolidated cyp1a2 cyp2b6 cyp2c19 cyp2c8 cyp3a4 cyp450 dpa formations hlms invitro1 isozyme ketoconazole khellactone km1 m4 m5 m6 menten metabolisms michaelis naphthoflavone praeruptorin pyranocoumarins uhplc
Tagcloud (Intersection) ?