EPS15 and AGFG1

Number of citations of the paper that reports this interaction (PubMedID 9303539)
48

Data Source:
BioGRID (biochemical)
HPRD (two hybrid, in vitro, in vivo)

		EPS15	AGFG1
Description		epidermal growth factor receptor pathway substrate 15	ArfGAP with FG repeats 1
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GO Annotations	Cellular Component	Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane Clathrin-coated Pit Basal Plasma Membrane Membrane Aggresome Apical Plasma Membrane AP-2 Adaptor Complex Clathrin Coat Of Coated Pit Clathrin-coated Vesicle Early Endosome Membrane Synapse Ciliary Membrane Postsynaptic Endocytic Zone Glutamatergic Synapse	Nucleus Nuclear Pore Cytoplasm Cytosol Cytoplasmic Vesicle Cell Projection Neuronal Cell Body
	Molecular Function	Calcium Ion Binding Protein Binding SH3 Domain Binding Protein-macromolecule Adaptor Activity Polyubiquitin Modification-dependent Protein Binding Identical Protein Binding Ubiquitin Binding Cadherin Binding Metal Ion Binding	DNA Binding RNA Binding GTPase Activator Activity Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Positive Regulation Of Receptor Recycling Golgi To Endosome Transport Endocytosis Protein Transport Vesicle Organization Endosomal Transport Receptor-mediated Endocytosis Of Virus By Host Cell Endocytic Recycling Regulation Of Protein Localization Regulation Of Cell Population Proliferation Symbiont Entry Into Host Cell Clathrin Coat Assembly Ubiquitin-dependent Endocytosis Postsynaptic Neurotransmitter Receptor Internalization	Acrosome Assembly MRNA Export From Nucleus Spermatogenesis Spermatid Nucleus Differentiation Cell Differentiation Intermediate Filament Organization MRNA Transport
Pathways		EGFR downregulation Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis InlB-mediated entry of Listeria monocytogenes into host cell Degradation of CDH1	Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs
Diseases
GWAS		Blood urea nitrogen levels ( 31152163) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Hip circumference adjusted for BMI ( 34021172) IgE grass sensitization ( 22036096) PR interval ( 30046033 32439900)	Airway hyperresponsiveness ( 23984888) Asthma ( 31959851) Mild influenza (H1N1) infection ( 26379185)
Interacting Genes		62 interacting genes: AGFG1 AGFG2 AP1G1 AP2A1 AP2A2 CDC40 CLINT1 CORO7 CRK DLGAP5 DNM1 DNM2 DRAM1 EGFR ELF3 EPN1 EPN2 FCHO2 GRB2 HGS ITSN1 LAPTM5 LMTK3 MAPK14 MLLT10 MLLT6 MOB4 MTNR1A NAGPA NEDD4 NUMB NUMBL PALMD PICALM PRKN REPS2 RNF11 RNF26 SCAMP1 SH3BP4 SNAP91 SPART SPATA31E1 SPOPL STAM2 STAMBP STON2 SYNJ1 TC2N TFAP2A TMEM114 UBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2H UBQLN1 UBQLN3 USP8 WEE1	15 interacting genes: APC APP DNAJC5 EPS15 EPS15L1 ITSN1 MFHAS1 NYAP2 OGT PKIA POLE2 RNF216 TRIM54 VAMP7 XPO1
Entrez ID		2060	3267
HPRD ID		08968	02918
Ensembl ID		ENSG00000085832	ENSG00000173744
Uniprot IDs		A0A994J5A3 A0A994J5J3 B7Z240 P42566	A0A0S2Z444 P52594
PDB IDs		1C07 1EH2 1F8H 1FF1 2IV9 2JXC 4RH5 4RH9 4RHG 4S0G 5AWT 5AWU 5JP2	2D9L 2OLM 2VX8
Enriched GO Terms of Interacting Partners?		Endocytosis Clathrin-coated Pit Import Into Cell Clathrin-coated Vesicle Receptor-mediated Endocytosis Vesicle-mediated Transport Clathrin-dependent Endocytosis Synaptic Vesicle Endocytosis Presynaptic Endocytosis Receptor Internalization Clathrin Coat Assembly Modification-dependent Protein Catabolic Process Vesicle Organization Vesicle-mediated Transport In Synapse Establishment Of Localization In Cell Endosome Vesicle Budding From Membrane Proteolysis Involved In Protein Catabolic Process Ubiquitin Conjugating Enzyme Activity Clathrin Binding Cytoplasmic Vesicle Clathrin Adaptor Activity Membrane Organization Cytosol Intracellular Vesicle Ubiquitin-dependent Protein Catabolic Process Protein Localization To Vacuole Post-translational Protein Modification Protein Ubiquitination Post-Golgi Vesicle-mediated Transport Protein Localization To Lysosome Vacuolar Transport Protein K48-linked Ubiquitination Establishment Of Protein Localization To Vacuole Membrane Coat Macromolecule Catabolic Process Clathrin Vesicle Coat Proteolysis Protein Targeting To Lysosome Cellular Localization Lysosomal Transport Negative Regulation Of Cellular Response To Growth Factor Stimulus Protein Modification By Small Protein Conjugation AP-2 Adaptor Complex Endocytic Vesicle Membrane Phosphatidylinositol-4,5-bisphosphate Binding Protein Polyubiquitination Synaptic Vesicle Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Catabolic Process	Clathrin-coated Pit Vesicle-mediated Transport In Synapse Regulation Of Protein Localization Negative Regulation Of Protein Localization To Nucleus Clathrin Coat Of Coated Pit Establishment Of Localization In Cell Postsynaptic Endocytic Zone Vesicle-mediated Transport Intracellular Transport Platelet Alpha Granule Cytoplasm Plasma Membrane Bounded Cell Projection Cellular Localization Regulation Of Protein Catabolic Process Negative Regulation Of Microtubule Depolymerization Regulation Of Protein Localization To Nucleus Regulation Of Microtubule Depolymerization Negative Regulation Of Protein Serine/threonine Kinase Activity Intracellular Signal Transduction Negative Regulation Of Microtubule Polymerization Or Depolymerization Lamellipodium Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Toll-like Receptor Signaling Pathway Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Signaling Positive Regulation Of Toll Signaling Pathway Regulation Of CAMP/PKA Signal Transduction Endocytosis Cytoplasmic Vesicle Negative Regulation Of CAMP-dependent Protein Kinase Activity Presynaptic Endocytosis Synaptic Vesicle Endocytosis Exocytosis Negative Regulation Of Type I Interferon Production Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Negative Regulation Of Signal Transduction Regulation Of Mitotic Cell Cycle Protein-containing Complex Organization Apoptotic Process Presynapse Regulation Of Glycolytic Process Programmed Cell Death Negative Regulation Of Protein Localization Synapse Protein-macromolecule Adaptor Activity Azurophil Granule Membrane Cell Death
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