EPS15 and SNAP91

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		EPS15	SNAP91
Description		epidermal growth factor receptor pathway substrate 15	synaptosome associated protein 91
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane Clathrin-coated Pit Basal Plasma Membrane Membrane Aggresome Apical Plasma Membrane AP-2 Adaptor Complex Clathrin Coat Of Coated Pit Clathrin-coated Vesicle Early Endosome Membrane Synapse Ciliary Membrane Postsynaptic Endocytic Zone Glutamatergic Synapse	Plasma Membrane Clathrin-coated Pit Synaptic Vesicle Membrane Clathrin-coated Vesicle Extrinsic Component Of Presynaptic Endocytic Zone Membrane
	Molecular Function	Calcium Ion Binding Protein Binding SH3 Domain Binding Protein-macromolecule Adaptor Activity Polyubiquitin Modification-dependent Protein Binding Identical Protein Binding Ubiquitin Binding Cadherin Binding Metal Ion Binding	SNARE Binding Protein Binding Phospholipid Binding 1-phosphatidylinositol Binding Phosphatidylinositol-4,5-bisphosphate Binding Protein Kinase Binding Clathrin Binding Clathrin Heavy Chain Binding
	Biological Process	Positive Regulation Of Receptor Recycling Golgi To Endosome Transport Endocytosis Protein Transport Vesicle Organization Endosomal Transport Receptor-mediated Endocytosis Of Virus By Host Cell Endocytic Recycling Regulation Of Protein Localization Regulation Of Cell Population Proliferation Symbiont Entry Into Host Cell Clathrin Coat Assembly Ubiquitin-dependent Endocytosis Postsynaptic Neurotransmitter Receptor Internalization	Vesicle Budding From Membrane Protein Transport Regulation Of Receptor-mediated Endocytosis Clathrin Coat Assembly Clathrin-dependent Endocytosis Regulation Of Clathrin-dependent Endocytosis
Pathways		EGFR downregulation Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis InlB-mediated entry of Listeria monocytogenes into host cell Degradation of CDH1	Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs
Diseases
GWAS		Blood urea nitrogen levels ( 31152163) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Hip circumference adjusted for BMI ( 34021172) IgE grass sensitization ( 22036096) PR interval ( 30046033 32439900)	Age-related hearing impairment ( 34108613) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Bipolar disorder with mood-incongruent psychosis ( 23092984) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Electrodermal activity ( 25387706) Macular thickness ( 30535121) Refractive error ( 32231278) Schizophrenia ( 28991256 29483656 30285260)
Interacting Genes		62 interacting genes: AGFG1 AGFG2 AP1G1 AP2A1 AP2A2 CDC40 CLINT1 CORO7 CRK DLGAP5 DNM1 DNM2 DRAM1 EGFR ELF3 EPN1 EPN2 FCHO2 GRB2 HGS ITSN1 LAPTM5 LMTK3 MAPK14 MLLT10 MLLT6 MOB4 MTNR1A NAGPA NEDD4 NUMB NUMBL PALMD PICALM PRKN REPS2 RNF11 RNF26 SCAMP1 SH3BP4 SNAP91 SPART SPATA31E1 SPOPL STAM2 STAMBP STON2 SYNJ1 TC2N TFAP2A TMEM114 UBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2H UBQLN1 UBQLN3 USP8 WEE1	15 interacting genes: ABI2 AP2A2 AP2B1 DNAJC5 EPS15 ERBB2 ERBB3 ERBB4 GEM MIPOL1 NECAP1 OGT PLCG1 TRAF3IP1 TUBA1B
Entrez ID		2060	9892
HPRD ID		08968	06391
Ensembl ID		ENSG00000085832	ENSG00000065609
Uniprot IDs		A0A994J5A3 A0A994J5J3 B7Z240 P42566	B7Z2N2 E9PDG8 O60641
PDB IDs		1C07 1EH2 1F8H 1FF1 2IV9 2JXC 4RH5 4RH9 4RHG 4S0G 5AWT 5AWU 5JP2
Enriched GO Terms of Interacting Partners?		Endocytosis Clathrin-coated Pit Import Into Cell Clathrin-coated Vesicle Receptor-mediated Endocytosis Vesicle-mediated Transport Clathrin-dependent Endocytosis Synaptic Vesicle Endocytosis Presynaptic Endocytosis Receptor Internalization Clathrin Coat Assembly Modification-dependent Protein Catabolic Process Vesicle Organization Vesicle-mediated Transport In Synapse Establishment Of Localization In Cell Endosome Vesicle Budding From Membrane Proteolysis Involved In Protein Catabolic Process Ubiquitin Conjugating Enzyme Activity Clathrin Binding Cytoplasmic Vesicle Clathrin Adaptor Activity Membrane Organization Cytosol Intracellular Vesicle Ubiquitin-dependent Protein Catabolic Process Protein Localization To Vacuole Post-translational Protein Modification Protein Ubiquitination Post-Golgi Vesicle-mediated Transport Protein Localization To Lysosome Vacuolar Transport Protein K48-linked Ubiquitination Establishment Of Protein Localization To Vacuole Membrane Coat Macromolecule Catabolic Process Clathrin Vesicle Coat Proteolysis Protein Targeting To Lysosome Cellular Localization Lysosomal Transport Negative Regulation Of Cellular Response To Growth Factor Stimulus Protein Modification By Small Protein Conjugation AP-2 Adaptor Complex Endocytic Vesicle Membrane Phosphatidylinositol-4,5-bisphosphate Binding Protein Polyubiquitination Synaptic Vesicle Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Catabolic Process	Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Postsynaptic Neurotransmitter Receptor Internalization Vesicle-mediated Transport In Synapse AP-2 Adaptor Complex Epidermal Growth Factor Receptor Signaling Pathway Basal Plasma Membrane Clathrin-coated Pit ERBB3:ERBB2 Complex ERBB Signaling Pathway ERBB2 Signaling Pathway Neuregulin Receptor Activity ErbB-3 Class Receptor Binding ERBB2-ERBB4 Signaling Pathway Presynaptic Endocytosis Cellular Response To Epidermal Growth Factor Stimulus Peptidyl-tyrosine Phosphorylation Response To Epidermal Growth Factor Postsynaptic Endocytic Zone ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway ERBB4 Signaling Pathway Positive Regulation Of Epithelial Cell Proliferation Receptor Internalization Clathrin Adaptor Complex Neuromuscular Junction Clathrin Adaptor Activity Endolysosome Membrane Heart Development Schwann Cell Development Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Post-anal Tail Morphogenesis Cytoplasmic Side Of Plasma Membrane Clathrin Coat Assembly Clathrin-coated Endocytic Vesicle Protein Tyrosine Kinase Activity Peripheral Nervous System Development Membrane Coat Clathrin-dependent Endocytosis Protein Localization To Postsynaptic Membrane Protein Localization To Postsynapse Regulation Of Epithelial Cell Proliferation Cellular Localization Establishment Of Localization In Cell Receptor-mediated Endocytosis Synaptic Vesicle Endocytosis Endocytosis Growth Factor Binding Receptor Complex Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Establishment Of Planar Polarity Involved In Nephron Morphogenesis
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