EPS15 and ELF3

Number of citations of the paper that reports this interaction (PubMedID 10064583)
53

Data Source:
HPRD (two hybrid, in vivo)

		EPS15	ELF3
Description		epidermal growth factor receptor pathway substrate 15	E74 like ETS transcription factor 3
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GO Annotations	Cellular Component	Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane Clathrin-coated Pit Basal Plasma Membrane Membrane Aggresome Apical Plasma Membrane AP-2 Adaptor Complex Clathrin Coat Of Coated Pit Clathrin-coated Vesicle Early Endosome Membrane Synapse Ciliary Membrane Postsynaptic Endocytic Zone Glutamatergic Synapse	Chromatin Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol
	Molecular Function	Calcium Ion Binding Protein Binding SH3 Domain Binding Protein-macromolecule Adaptor Activity Polyubiquitin Modification-dependent Protein Binding Identical Protein Binding Ubiquitin Binding Cadherin Binding Metal Ion Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Positive Regulation Of Receptor Recycling Golgi To Endosome Transport Endocytosis Protein Transport Vesicle Organization Endosomal Transport Receptor-mediated Endocytosis Of Virus By Host Cell Endocytic Recycling Regulation Of Protein Localization Regulation Of Cell Population Proliferation Symbiont Entry Into Host Cell Clathrin Coat Assembly Ubiquitin-dependent Endocytosis Postsynaptic Neurotransmitter Receptor Internalization	Blastocyst Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Inflammatory Response Anatomical Structure Morphogenesis Cell Differentiation Extracellular Matrix Organization Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Mammary Gland Involution
Pathways		EGFR downregulation Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis InlB-mediated entry of Listeria monocytogenes into host cell Degradation of CDH1	Pre-NOTCH Transcription and Translation
Drugs
Diseases
GWAS		Blood urea nitrogen levels ( 31152163) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Hip circumference adjusted for BMI ( 34021172) IgE grass sensitization ( 22036096) PR interval ( 30046033 32439900)	Systemic lupus erythematosus ( 33272962)
Interacting Genes		62 interacting genes: AGFG1 AGFG2 AP1G1 AP2A1 AP2A2 CDC40 CLINT1 CORO7 CRK DLGAP5 DNM1 DNM2 DRAM1 EGFR ELF3 EPN1 EPN2 FCHO2 GRB2 HGS ITSN1 LAPTM5 LMTK3 MAPK14 MLLT10 MLLT6 MOB4 MTNR1A NAGPA NEDD4 NUMB NUMBL PALMD PICALM PRKN REPS2 RNF11 RNF26 SCAMP1 SH3BP4 SNAP91 SPART SPATA31E1 SPOPL STAM2 STAMBP STON2 SYNJ1 TC2N TFAP2A TMEM114 UBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2H UBQLN1 UBQLN3 USP8 WEE1	16 interacting genes: AR CREBBP EGFR EP300 EPS15 JUN MED23 MYC NFE2L2 NFKB1 PAK1 SOX9 TAF9 TBP XRCC5 XRCC6
Entrez ID		2060	1999
HPRD ID		08968	03722
Ensembl ID		ENSG00000085832	ENSG00000163435
Uniprot IDs		A0A994J5A3 A0A994J5J3 B7Z240 P42566	P78545
PDB IDs		1C07 1EH2 1F8H 1FF1 2IV9 2JXC 4RH5 4RH9 4RHG 4S0G 5AWT 5AWU 5JP2	2E8P
Enriched GO Terms of Interacting Partners?		Endocytosis Clathrin-coated Pit Import Into Cell Clathrin-coated Vesicle Receptor-mediated Endocytosis Vesicle-mediated Transport Clathrin-dependent Endocytosis Synaptic Vesicle Endocytosis Presynaptic Endocytosis Receptor Internalization Clathrin Coat Assembly Modification-dependent Protein Catabolic Process Vesicle Organization Vesicle-mediated Transport In Synapse Establishment Of Localization In Cell Endosome Vesicle Budding From Membrane Proteolysis Involved In Protein Catabolic Process Ubiquitin Conjugating Enzyme Activity Clathrin Binding Cytoplasmic Vesicle Clathrin Adaptor Activity Membrane Organization Cytosol Intracellular Vesicle Ubiquitin-dependent Protein Catabolic Process Protein Localization To Vacuole Post-translational Protein Modification Protein Ubiquitination Post-Golgi Vesicle-mediated Transport Protein Localization To Lysosome Vacuolar Transport Protein K48-linked Ubiquitination Establishment Of Protein Localization To Vacuole Membrane Coat Macromolecule Catabolic Process Clathrin Vesicle Coat Proteolysis Protein Targeting To Lysosome Cellular Localization Lysosomal Transport Negative Regulation Of Cellular Response To Growth Factor Stimulus Protein Modification By Small Protein Conjugation AP-2 Adaptor Complex Endocytic Vesicle Membrane Phosphatidylinositol-4,5-bisphosphate Binding Protein Polyubiquitination Synaptic Vesicle Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Catabolic Process	Transcription Cis-regulatory Region Binding Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Initiation Positive Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Initiation Positive Regulation Of Macromolecule Metabolic Process Regulation Of MiRNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Intracellular Signaling Cassette MAPK Cascade Transcription Regulator Complex Positive Regulation Of MiRNA Metabolic Process Positive Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Protein-containing Complex Regulation Of Transcription Initiation By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of MiRNA Transcription Positive Regulation Of Biosynthetic Process Regulation Of RNA Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Nucleobase-containing Compound Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process DNA-templated Transcription Protein-DNA Complex Nucleoplasm Macromolecule Biosynthetic Process Chromatin Chromatin Binding Transcription Coactivator Binding Nucleic Acid Metabolic Process Regulation Of Cell Differentiation Positive Regulation Of MiRNA Transcription Regulation Of Immune System Process DNA Binding Negative Regulation Of Apoptotic Process Damaged DNA Binding Regulation Of Macromolecule Metabolic Process Cellular Response To Radiation Negative Regulation Of Programmed Cell Death DNA-binding Transcription Factor Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Intracellular Signal Transduction
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