RFXAP and RFXANK

Number of citations of the paper that reports this interaction (PubMedID 11463838)
33

Data Source:
HPRD (in vitro, in vivo)

		RFXAP	RFXANK
Description		regulatory factor X associated protein	regulatory factor X associated ankyrin containing protein
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GO Annotations	Cellular Component	Nucleus Nuclear Speck RNA Polymerase II Transcription Regulator Complex	Nucleus Nucleoplasm Cytoplasm Cytosol Intercellular Bridge RNA Polymerase II Transcription Regulator Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Histone Deacetylase Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Positive Regulation Of MHC Class II Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II	Ras Protein Signal Transduction Positive Regulation Of MHC Class II Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II
Pathways
Drugs
Diseases		Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency Bare lymphocyte syndrome (BLS) type2	Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency Bare lymphocyte syndrome (BLS) type2
GWAS		Metabolite levels ( 23823483) Perioperative myocardial infarction in coronary artery bypass surgery ( 25948407)	Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Bipolar II disorder ( 31043756) Refractive error ( 32231278)
Interacting Genes		4 interacting genes: EPS8 RFX5 RFXANK SMARCA4	6 interacting genes: CIITA HDAC4 HDAC5 RAF1 RFX5 RFXAP
Entrez ID		5994	8625
HPRD ID		03515	04435
Ensembl ID		ENSG00000133111	ENSG00000064490
Uniprot IDs		O00287	A0A024R7P0 O14593
PDB IDs		2KW3	3UXG 3V30 6MEW
Enriched GO Terms of Interacting Partners?		Positive Regulation Of MHC Class II Biosynthetic Process Transcription Coregulator Binding	Positive Regulation Of MHC Class II Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Biosynthetic Process Interferon-mediated Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Histone Deacetylase Activity, Hydrolytic Mechanism Positive Regulation Of RNA Metabolic Process Protein Lysine Deacetylase Activity Type II Interferon-mediated Signaling Pathway Positive Regulation Of Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Histone Deacetylase Binding Negative Regulation Of Myotube Differentiation Histone Deacetylase Activity DNA-binding Transcription Factor Binding DNA-binding Transcription Activator Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Negative Regulation Of Striated Muscle Cell Differentiation Histone Deacetylase Complex Regulation Of Macromolecule Biosynthetic Process Regulation Of Myotube Differentiation Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Metabolic Process Negative Regulation Of Muscle Cell Differentiation Regulation Of RNA Metabolic Process Lipid Localization Cytokine-mediated Signaling Pathway Nuclear Speck Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Regulation Of Striated Muscle Cell Differentiation Lymphocyte Activation Death-inducing Signaling Complex Assembly Stress-induced Mitochondrial Fusion Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process B Cell Differentiation Leukocyte Activation RNA Polymerase II Transcription Regulator Complex Negative Regulation Of RNA Metabolic Process Regulation Of Muscle Cell Differentiation Cell Activation Negative Regulation Of Nucleobase-containing Compound Metabolic Process
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