RFXAP and RFX5

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology)
HPRD (in vivo, two hybrid)

		RFXAP	RFX5
Description		regulatory factor X associated protein	regulatory factor X5
Image
GO Annotations	Cellular Component	Nucleus Nuclear Speck RNA Polymerase II Transcription Regulator Complex	Chromatin Nucleus Nucleoplasm RNA Polymerase II Transcription Regulator Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coregulator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Positive Regulation Of MHC Class II Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of MHC Class II Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II
Pathways
Drugs
Diseases		Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency Bare lymphocyte syndrome (BLS) type2	Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency Bare lymphocyte syndrome (BLS) type2
GWAS		Metabolite levels ( 23823483) Perioperative myocardial infarction in coronary artery bypass surgery ( 25948407)	Body mass index ( 26426971)
Interacting Genes		4 interacting genes: EPS8 RFX5 RFXANK SMARCA4	6 interacting genes: APP CFAP298 CIITA HDAC2 RFXANK RFXAP
Entrez ID		5994	5993
HPRD ID		03515	03517
Ensembl ID		ENSG00000133111	ENSG00000143390
Uniprot IDs		O00287	P48382
PDB IDs		2KW3	2KW3 3V30
Enriched GO Terms of Interacting Partners?		Positive Regulation Of MHC Class II Biosynthetic Process Transcription Coregulator Binding	Positive Regulation Of MHC Class II Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Cellular Response To Catecholamine Stimulus Response To Catecholamine Positive Regulation Of DNA-templated Transcription Negative Regulation Of Transcription By Competitive Promoter Binding Histone Deacetylase Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Dendrite Development Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Response To Amyloid-beta Positive Regulation Of Toll Signaling Pathway Nucleus Positive Regulation Of Male Mating Behavior Positive Regulation Of Interleukin-1 Production Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Acetylcholine Receptor Activator Activity PTB Domain Binding Positive Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Golgi Lumen Regulation Of Interleukin-1 Production Positive Regulation Of Tumor Necrosis Factor Production Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Cell Projection Organization Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Protein De-2-hydroxyisobutyrylase Activity Protein Lysine Delactylase Activity Fungiform Papilla Formation Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway
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