BCKDK and SPTA1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		BCKDK	SPTA1
Description		branched chain keto acid dehydrogenase kinase	spectrin alpha, erythrocytic 1
Image
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Oxoglutarate Dehydrogenase Complex	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cell Cortex Spectrin Cytoplasmic Side Of Plasma Membrane Spectrin-associated Cytoskeleton Actin Cytoskeleton Membrane Cell Junction Axon Cortical Cytoskeleton Cortical Actin Cytoskeleton Cuticular Plate Cell Projection
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine Phosphatase Activity Pyruvate Dehydrogenase (acetyl-transferring) Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Transferase Activity, Transferring Phosphorus-containing Groups [3-methyl-2-oxobutanoate Dehydrogenase (acetyl-transferring)] Kinase Activity Protein Serine Kinase Activity Catalytic Activity, Acting On A Protein	Actin Binding Structural Constituent Of Cytoskeleton Calcium Ion Binding Protein Binding Metal Ion Binding Actin Filament Binding
	Biological Process	L-isoleucine Catabolic Process L-leucine Catabolic Process L-valine Catabolic Process Spermatogenesis Lipid Biosynthetic Process Amino Acid Catabolic Process Branched-chain Amino Acid Catabolic Process Regulation Of Pyruvate Decarboxylation To Acetyl-CoA Regulation Of Glucose Metabolic Process	Lymphocyte Homeostasis Porphyrin-containing Compound Biosynthetic Process Plasma Membrane Organization Actin Filament Organization Regulation Of Cell Shape Actin Cytoskeleton Organization Hemopoiesis Positive Regulation Of T Cell Proliferation Actin Filament Capping
Pathways		Branched-chain amino acid catabolism Branched-chain ketoacid dehydrogenase kinase deficiency	NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins RAF/MAP kinase cascade COPI-mediated anterograde transport
Drugs		Adenosine 5'-[gamma-thio]triphosphate
Diseases			Hereditary spherocytosis (SPH) Hereditary elliptocytosis (HE)
GWAS		Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Parkinson's disease ( 25064009) Systolic blood pressure ( 31928498) Triglyceride levels ( 31928498) Waist circumference ( 31928498)	Glycated hemoglobin levels ( 20858683 34059833 28898252) Heel bone mineral density x serum urate levels interaction ( 34046847) Hemoglobin A1c levels ( 29844224) Hemoglobin levels ( 32327693) hemolysis of donated blood (osmotic) ( 34014839) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 32888494 27863252) Lymphocyte count ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular hemoglobin concentration ( 27863252 32888494 29403010) Mean corpuscular volume ( 32888494 29403010 27863252) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Neutrophil percentage of white cells ( 32888494 27863252) Night sleep phenotypes ( 27126917) Other erythrocyte phenotypes ( 19862010) Platelet distribution width ( 32888494) QRS duration ( 27577874) Red blood cell count ( 32888494) Red blood cell traits ( 23222517) Red cell distribution width ( 28957414 32888494 27863252) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 27863252 32888494) White blood cell count ( 32888494)
Interacting Genes		11 interacting genes: APP EPS8 FBXO7 FXR1 FXR2 LSM8 NR5A2 SPTA1 STAT3 TRAF4 UBC	27 interacting genes: ABI1 ABL1 ACTA1 ADD1 ANK1 BCKDK C21orf58 CCDC185 CIMAP1B DGCR6L ENAH EVL EXOSC5 FANCC FASLG GADD45GIP1 KRT75 PKP2 PLEC SLC9A2 SPTB SPTBN2 TSHZ2 TXN2 VASP YWHAQ ZNF326
Entrez ID		10295	6708
HPRD ID		12523	01685
Ensembl ID		ENSG00000103507	ENSG00000163554
Uniprot IDs		O14874	P02549
PDB IDs		8F5F 8F5J 8F5S 9DI9	1OWA 3LBX 5J4O
Enriched GO Terms of Interacting Partners?		Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Regulation Of Neuronal Synaptic Plasticity Neuron Projection Positive Regulation Of Catabolic Process Regulation Of Developmental Process Positive Regulation Of Small Molecule Metabolic Process Positive Regulation Of Long-term Neuronal Synaptic Plasticity Negative Regulation Of Long-term Synaptic Potentiation Regulation Of Purine Nucleotide Metabolic Process Regulation Of Stem Cell Differentiation Translation Regulator Activity Positive Regulation Of JNK Cascade Regulation Of Cell Differentiation Positive Regulation Of Protein Metabolic Process Regulation Of Intracellular Signal Transduction Positive Regulation Of MRNA Catabolic Process Regulation Of Biological Quality Stem Cell Population Maintenance Maintenance Of Cell Number Ubiquitin Protein Ligase Binding Regulation Of MiRNA-mediated Gene Silencing Dentate Gyrus Development Positive Regulation Of Phosphate Metabolic Process Regulation Of Post-transcriptional Gene Silencing Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Small Molecule Metabolic Process Regulation Of Cell Shape Regulation Of JNK Cascade Post-transcriptional Regulation Of Gene Expression Protein Heterodimerization Activity Actin Filament Capping Positive Regulation Of MRNA Metabolic Process Cytoplasmic Translational Initiation Amyloid-beta Complex Axon Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of Tumor Necrosis Factor Production Amylin Binding Positive Regulation Of ATP Metabolic Process Positive Regulation Of Toll Signaling Pathway Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Actin Filament Depolymerization Temperature Homeostasis Regulation Of Stress-activated Protein Kinase Signaling Cascade Regulation Of Stress-activated MAPK Cascade Zygotic Genome Activation Positive Regulation Of Guanylate Cyclase Activity Presynaptic Modulation Of Chemical Synaptic Transmission	Supramolecular Fiber Organization Actin Filament Organization Actin Polymerization Or Depolymerization Structural Constituent Of Cytoskeleton Profilin Binding Cytoskeleton Regulation Of Actin Filament-based Process Cytoskeleton Organization Regulation Of Actin Filament Polymerization Actin Binding Regulation Of Actin Filament Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Filopodium Cadherin Binding Lamellipodium Regulation Of Actin Cytoskeleton Organization Actin Filament Binding Actin Cytoskeleton Organization Actin Filament Capping Regulation Of Supramolecular Fiber Organization SH3 Domain Binding Negative Regulation Of Actin Filament Depolymerization Actin Filament-based Process Regulation Of Protein-containing Complex Assembly Regulation Of Cellular Component Size Focal Adhesion Negative Regulation Of Actin Filament Polymerization Spectrin-associated Cytoskeleton Regulation Of Actin Filament Depolymerization Spectrin Regulation Of Cytoskeleton Organization Intermediate Filament Organization Negative Regulation Of Protein-containing Complex Disassembly Cell Junction Regulation Of Protein Depolymerization Intermediate Filament Cytoskeleton Organization Ankyrin Binding Intermediate Filament-based Process Postsynapse Regulation Of Postsynaptic Specialization Assembly Cell Projection Cytoskeletal Anchor Activity Spectrin Binding Actin Cytoskeleton Skeletal Muscle Fiber Development Regulation Of Protein-containing Complex Disassembly Cellular Response To Fluid Shear Stress Myotube Cell Development Negative Regulation Of Protein-containing Complex Assembly
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