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BCKDK and EPS8
Number of citations of the paper that reports this interaction (PubMedID
21988832
)
38
Data Source:
BioGRID
(two hybrid)
BCKDK
EPS8
Description
branched chain keto acid dehydrogenase kinase
EGFR pathway substrate 8, signaling adaptor
Image
GO Annotations
Cellular Component
Mitochondrion
Mitochondrial Matrix
Oxoglutarate Dehydrogenase Complex
Cytoplasm
Plasma Membrane
Brush Border
Cell Cortex
Postsynaptic Density
Membrane
NMDA Selective Glutamate Receptor Complex
Growth Cone
Vesicle
Stereocilium
Stereocilium Bundle
Stereocilium Tip
Ruffle Membrane
Cell Projection
Neuron Projection
Synapse
Extracellular Exosome
Glutamatergic Synapse
Molecular Function
Nucleotide Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Serine/threonine Phosphatase Activity
Pyruvate Dehydrogenase (acetyl-transferring) Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Transferase Activity, Transferring Phosphorus-containing Groups
[3-methyl-2-oxobutanoate Dehydrogenase (acetyl-transferring)] Kinase Activity
Protein Serine Kinase Activity
Catalytic Activity, Acting On A Protein
Actin Binding
Protein Binding
Small GTPase Binding
Biological Process
L-isoleucine Catabolic Process
L-leucine Catabolic Process
L-valine Catabolic Process
Spermatogenesis
Lipid Biosynthetic Process
Amino Acid Catabolic Process
Branched-chain Amino Acid Catabolic Process
Regulation Of Pyruvate Decarboxylation To Acetyl-CoA
Regulation Of Glucose Metabolic Process
Rho Protein Signal Transduction
Adult Locomotory Behavior
Regulation Of Cell Shape
Exit From Mitosis
Rac Protein Signal Transduction
Actin Cytoskeleton Organization
Regulation Of Actin Filament Length
Regulation Of Rho Protein Signal Transduction
Dendritic Cell Migration
Behavioral Response To Ethanol
Barbed-end Actin Filament Capping
Actin Filament Bundle Assembly
Actin Crosslink Formation
Actin Polymerization-dependent Cell Motility
Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels
Positive Regulation Of Ruffle Assembly
Cellular Response To Leukemia Inhibitory Factor
Pathways
Branched-chain amino acid catabolism
Branched-chain ketoacid dehydrogenase kinase deficiency
Sensory processing of sound by inner hair cells of the cochlea
Sensory processing of sound by outer hair cells of the cochlea
Drugs
Adenosine 5'-[gamma-thio]triphosphate
Diseases
GWAS
Bipolar disorder (
31043756
)
Bipolar I disorder (
31043756
)
Parkinson's disease (
25064009
)
Systolic blood pressure (
31928498
)
Triglyceride levels (
31928498
)
Waist circumference (
31928498
)
Metabolite levels (
23823483
)
Protein quantitative trait loci (
18464913
)
Interacting Genes
11 interacting genes:
APP
EPS8
FBXO7
FXR1
FXR2
LSM8
NR5A2
SPTA1
STAT3
TRAF4
UBC
61 interacting genes:
ABI1
ACTA1
ADAM22
AIMP2
ALDH7A1
ARMC1
BAIAP2
BCKDK
BLOC1S6
BORCS6
BYSL
C19orf25
C6orf141
C8orf33
CASK
CBL
CCDC85B
CSNK2B
CTNNA3
CXCL2
DNALI1
DVL1
EGFR
GOLGA8EP
GRB2
GULP1
HNRNPC
HOOK2
INPP5J
ITGB1
ITGB3
ITGB5
ITSN2
MAP1LC3B
MAP3K11
MRPL20
MYO15A
NACC2
NFKB2
PCM1
PROSER2
RCAN3
RFXAP
RSPH14
RUNX1T1
SCRN3
SERPINA5
SF3B3
SHB
SHC1
SLC27A4
SMARCE1
SOS1
SRC
TDP2
TEX28
TPRN
USP6NL
XAGE2
XRCC6
ZZZ3
Entrez ID
10295
2059
HPRD ID
12523
02563
Ensembl ID
ENSG00000103507
ENSG00000151491
Uniprot IDs
O14874
B4E3T6
Q12929
PDB IDs
8F5F
8F5J
8F5S
9DI9
2E8M
7TZK
Enriched GO Terms of Interacting Partners
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Regulation Of Long-term Neuronal Synaptic Plasticity
Regulation Of Translation At Presynapse, Modulating Synaptic Transmission
Regulation Of Neuronal Synaptic Plasticity
Neuron Projection
Positive Regulation Of Catabolic Process
Regulation Of Developmental Process
Positive Regulation Of Small Molecule Metabolic Process
Positive Regulation Of Long-term Neuronal Synaptic Plasticity
Negative Regulation Of Long-term Synaptic Potentiation
Regulation Of Purine Nucleotide Metabolic Process
Regulation Of Stem Cell Differentiation
Translation Regulator Activity
Positive Regulation Of JNK Cascade
Regulation Of Cell Differentiation
Positive Regulation Of Protein Metabolic Process
Regulation Of Intracellular Signal Transduction
Positive Regulation Of MRNA Catabolic Process
Regulation Of Biological Quality
Stem Cell Population Maintenance
Maintenance Of Cell Number
Ubiquitin Protein Ligase Binding
Regulation Of MiRNA-mediated Gene Silencing
Dentate Gyrus Development
Positive Regulation Of Phosphate Metabolic Process
Regulation Of Post-transcriptional Gene Silencing
Regulation Of Reactive Oxygen Species Metabolic Process
Regulation Of Small Molecule Metabolic Process
Regulation Of Cell Shape
Regulation Of JNK Cascade
Post-transcriptional Regulation Of Gene Expression
Protein Heterodimerization Activity
Actin Filament Capping
Positive Regulation Of MRNA Metabolic Process
Cytoplasmic Translational Initiation
Amyloid-beta Complex
Axon
Growth Cone Lamellipodium
Regulation Of Response To Calcium Ion
Regulation Of Tumor Necrosis Factor Production
Amylin Binding
Positive Regulation Of ATP Metabolic Process
Positive Regulation Of Toll Signaling Pathway
Regulation Of Long-term Synaptic Potentiation
Negative Regulation Of Actin Filament Depolymerization
Temperature Homeostasis
Regulation Of Stress-activated Protein Kinase Signaling Cascade
Regulation Of Stress-activated MAPK Cascade
Zygotic Genome Activation
Positive Regulation Of Guanylate Cyclase Activity
Presynaptic Modulation Of Chemical Synaptic Transmission
Epidermal Growth Factor Receptor Signaling Pathway
Filopodium
ERBB Signaling Pathway
Protein Tyrosine Kinase Activator Activity
Supramolecular Fiber Organization
Actin Filament Organization
Symbiont Entry Into Host Cell
Ephrin Receptor Binding
Actin Filament Bundle Organization
Actin Filament Bundle Assembly
Shc-EGFR Complex
Focal Adhesion
Enzyme-linked Receptor Protein Signaling Pathway
Wound Healing, Spreading Of Epidermal Cells
Phosphotyrosine Residue Binding
Biological Process Involved In Interaction With Host
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Developmental Process
Schwann Cell Development
Ruffle
SH3 Domain Binding
Cellular Response To Growth Factor Stimulus
Cellular Response To Platelet-derived Growth Factor Stimulus
Epidermal Growth Factor Binding
ERBB2 Signaling Pathway
Contractile Actin Filament Bundle Assembly
Stress Fiber Assembly
Response To Platelet-derived Growth Factor
Neuregulin Binding
Integrin Complex
C-X3-C Chemokine Binding
Cell Adhesion Mediated By Integrin
Response To Growth Factor
Wound Healing, Spreading Of Cells
Response To Activity
Neurotrophin TRKA Receptor Binding
Endocytosis
Insulin Receptor Signaling Pathway
Integrin Binding
Virus Receptor Activity
Insulin-like Growth Factor Receptor Signaling Pathway
Epidermal Growth Factor Receptor Binding
Heterotypic Cell-cell Adhesion
Actin-based Cell Projection
Cellular Developmental Process
Import Into Cell
Schaffer Collateral - CA1 Synapse
Ruffle Membrane
Integrin-mediated Signaling Pathway
Lamellipodium
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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