BCKDK and NR5A2

Number of citations of the paper that reports this interaction (PubMedID 15604093)
0

Data Source:
BioGRID (two hybrid)

		BCKDK	NR5A2
Description		branched chain keto acid dehydrogenase kinase	nuclear receptor subfamily 5 group A member 2
Image
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Oxoglutarate Dehydrogenase Complex	Chromatin Nucleus Nucleoplasm Chromosome Cytoplasm RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine Phosphatase Activity Pyruvate Dehydrogenase (acetyl-transferring) Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Transferase Activity, Transferring Phosphorus-containing Groups [3-methyl-2-oxobutanoate Dehydrogenase (acetyl-transferring)] Kinase Activity Protein Serine Kinase Activity Catalytic Activity, Acting On A Protein	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coregulator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Double-stranded DNA Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Phospholipid Binding Zinc Ion Binding Lipid Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	L-isoleucine Catabolic Process L-leucine Catabolic Process L-valine Catabolic Process Spermatogenesis Lipid Biosynthetic Process Amino Acid Catabolic Process Branched-chain Amino Acid Catabolic Process Regulation Of Pyruvate Decarboxylation To Acetyl-CoA Regulation Of Glucose Metabolic Process	Primary Ovarian Follicle Growth Inner Cell Mass Cell Differentiation Positive Regulation Of T Cell Anergy Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Spermatogenesis Bile Acid Metabolic Process Hormone-mediated Signaling Pathway Embryo Development Ending In Birth Or Egg Hatching Tissue Development Neurogenesis Intracellular Receptor Signaling Pathway Exocrine Pancreas Development Positive Regulation Of Glucocorticoid Biosynthetic Process Negative Regulation Of Chondrocyte Differentiation Somatic Stem Cell Population Maintenance Embryonic Cleavage Positive Regulation Of T Cell Proliferation Regulation Of Cell Population Proliferation Homeostatic Process Cholesterol Homeostasis Positive Regulation Of Viral Genome Replication Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Inflammatory Response Positive Regulation Of T Cell Activation Cartilage Development Sertoli Cell Development Pancreas Morphogenesis Acinar Cell Differentiation Calcineurin-mediated Signaling Morula Formation Zygotic Genome Activation Cellular Response To Leukemia Inhibitory Factor Positive Regulation Of Stem Cell Differentiation Positive Regulation Of Tendon Cell Differentiation
Pathways		Branched-chain amino acid catabolism Branched-chain ketoacid dehydrogenase kinase deficiency	Estrogen-dependent gene expression
Drugs		Adenosine 5'-[gamma-thio]triphosphate
Diseases
GWAS		Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Parkinson's disease ( 25064009) Systolic blood pressure ( 31928498) Triglyceride levels ( 31928498) Waist circumference ( 31928498)	Age at voice drop ( 27182965) Cerebrospinal T-tau levels ( 28247064) Cervical high-risk human papilloma virus infection (persistent) ( 33225922) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) FEV1 ( 30804560) Gamma glutamyl transferase levels ( 29403010 33339817) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hepcidin/transferrin saturation ratio ( 27846281) Hyperinsulinemia in obesity ( 30327367) Hyperinsulinemia x BMI interaction ( 30327367) Inflammatory bowel disease ( 28067908) LDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) Length of menstrual cycle ( 30202859) Lung adenocarcinoma ( 28604730) Lung function (FVC) ( 30804560 30061609) Menarche (age at onset) ( 25231870) Myopia ( 27182965) Nicotine dependence ( 28440896) Non-alcoholic fatty liver disease activity score in non-alcoholic fatty liver disease ( 31311600) Pancreatic cancer ( 29422604 20101243 25086665 27579533 26098869) Refractive error ( 32231278) Rheumatoid arthritis ( 25014791) Ulcerative colitis ( 28067908) Uric acid levels ( 21294900) Urinary albumin excretion ( 30220432)
Interacting Genes		11 interacting genes: APP EPS8 FBXO7 FXR1 FXR2 LSM8 NR5A2 SPTA1 STAT3 TRAF4 UBC	24 interacting genes: ALB BCKDK CTNNB1 DDB2 EDF1 FTH1 GTF2H2C HSP90B1 NCOA1 NCOA3 NPPA NR0B2 NR1I2 NRIP1 NSD1 PNRC1 PNRC2 POLR2D PROX1 RAD54L2 RANBP2 SMARCD3 SREBF1 UBE2I
Entrez ID		10295	2494
HPRD ID		12523	06830
Ensembl ID		ENSG00000103507	ENSG00000116833
Uniprot IDs		O14874	F1D8R9 O00482
PDB IDs		8F5F 8F5J 8F5S 9DI9	1YOK 1YUC 1ZDU 2A66 3PLZ 3TX7 4DOR 4DOS 4IS8 4ONI 4PLD 4PLE 4RWV 5L0M 5L11 5SYZ 5UNJ 6OQX 6OQY 6OR1 6VC2 6VIF 7JYD 7JYE 7TT8 8F8M 8PKI
Enriched GO Terms of Interacting Partners?		Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Regulation Of Neuronal Synaptic Plasticity Neuron Projection Positive Regulation Of Catabolic Process Regulation Of Developmental Process Positive Regulation Of Small Molecule Metabolic Process Positive Regulation Of Long-term Neuronal Synaptic Plasticity Negative Regulation Of Long-term Synaptic Potentiation Regulation Of Purine Nucleotide Metabolic Process Regulation Of Stem Cell Differentiation Translation Regulator Activity Positive Regulation Of JNK Cascade Regulation Of Cell Differentiation Positive Regulation Of Protein Metabolic Process Regulation Of Intracellular Signal Transduction Positive Regulation Of MRNA Catabolic Process Regulation Of Biological Quality Stem Cell Population Maintenance Maintenance Of Cell Number Ubiquitin Protein Ligase Binding Regulation Of MiRNA-mediated Gene Silencing Dentate Gyrus Development Positive Regulation Of Phosphate Metabolic Process Regulation Of Post-transcriptional Gene Silencing Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Small Molecule Metabolic Process Regulation Of Cell Shape Regulation Of JNK Cascade Post-transcriptional Regulation Of Gene Expression Protein Heterodimerization Activity Actin Filament Capping Positive Regulation Of MRNA Metabolic Process Cytoplasmic Translational Initiation Amyloid-beta Complex Axon Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of Tumor Necrosis Factor Production Amylin Binding Positive Regulation Of ATP Metabolic Process Positive Regulation Of Toll Signaling Pathway Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Actin Filament Depolymerization Temperature Homeostasis Regulation Of Stress-activated Protein Kinase Signaling Cascade Regulation Of Stress-activated MAPK Cascade Zygotic Genome Activation Positive Regulation Of Guanylate Cyclase Activity Presynaptic Modulation Of Chemical Synaptic Transmission	Nuclear Receptor Binding Nuclear Retinoid X Receptor Binding Nuclear Retinoic Acid Receptor Binding Nucleus Nuclear Estrogen Receptor Binding Transcription Coregulator Binding Protein-containing Complex Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Chromatin Transcription Coregulator Activity Positive Regulation Of RNA Metabolic Process Transcription Coactivator Activity Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Nucleoplasm Nuclear Thyroid Hormone Receptor Binding Acinar Cell Differentiation Regulation Of Metabolic Process SUMO Ligase Complex Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Intracellular Receptor Signaling Pathway Response To Estradiol Regulation Of Nucleobase-containing Compound Metabolic Process DNA-templated Transcription Regulation Of Primary Metabolic Process Rhythmic Process Regulation Of Neuroblast Proliferation Negative Regulation Of Transcription By RNA Polymerase II Circadian Rhythm Regulation Of RNA Metabolic Process Transcription By RNA Polymerase II Positive Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Biosynthetic Process Neuron Fate Determination Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Protein-containing Complex Binding Nucleobase-containing Compound Biosynthetic Process Lens Morphogenesis In Camera-type Eye Hypothalamus Development Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Neural Precursor Cell Proliferation Negative Regulation Of Macromolecule Metabolic Process SUMO Transferase Activity
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?