EIF4G1 and UBE3A

Number of citations of the paper that reports this interaction (PubMedID 35831314)
73

Data Source:
BioGRID (biochemical, two hybrid)

		EIF4G1	UBE3A
Description		eukaryotic translation initiation factor 4 gamma 1	ubiquitin protein ligase E3A
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Ribosome Cytoplasmic Stress Granule Membrane Eukaryotic Translation Initiation Factor 4F Complex	Proteasome Complex Nucleus Cytoplasm Cytosol Synaptic Vesicle Glutamatergic Synapse Postsynaptic Cytosol
	Molecular Function	RNA Binding MRNA Binding Translation Initiation Factor Activity Protein Binding ATP Binding Translation Factor Activity, RNA Binding Eukaryotic Initiation Factor 4E Binding Translation Initiation Factor Binding Molecular Adaptor Activity	Transcription Coactivator Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Behavioral Fear Response Cap-dependent Translational Initiation Translation Translational Initiation Regulation Of Translation Regulation Of Translational Initiation Negative Regulation Of Autophagy Neuron Differentiation Positive Regulation Of Cell Growth Cellular Response To Nutrient Levels MiRNA-mediated Gene Silencing By Inhibition Of Translation Positive Regulation Of Translation In Response To Endoplasmic Reticulum Stress Positive Regulation Of Neuron Differentiation Positive Regulation Of Protein Metabolic Process Regulation Of Cellular Response To Stress Energy Homeostasis Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Protein Localization To Cell Periphery Positive Regulation Of Eukaryotic Translation Initiation Factor 4F Complex Assembly Regulation Of Presynapse Assembly	Protein Polyubiquitination Ovarian Follicle Development Proteolysis Ubiquitin-dependent Protein Catabolic Process Brain Development Positive Regulation Of Macromolecule Metabolic Process Protein Ubiquitination Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Androgen Receptor Signaling Pathway Positive Regulation Of Protein Ubiquitination Cellular Response To Nutrient Levels Response To Progesterone Sperm Entry Regulation Of Circadian Rhythm Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Synaptic Plasticity Rhythmic Process Animal Organ Development System Development Modulation Of Chemical Synaptic Transmission Progesterone Receptor Signaling Pathway Protein Autoubiquitination Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Prostate Gland Growth Protein K48-linked Ubiquitination Regulation Of Primary Metabolic Process Positive Regulation Of Protein Localization To Lysosome Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling Positive Regulation Of Golgi Lumen Acidification Regulation Of Ubiquitin-dependent Protein Catabolic Process
Pathways		ISG15 antiviral mechanism L13a-mediated translational silencing of Ceruloplasmin expression mTORC1-mediated signalling Deadenylation of mRNA Deadenylation of mRNA AUF1 (hnRNP D0) binds and destabilizes mRNA Translation initiation complex formation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) M-decay: degradation of maternal mRNAs by maternally stored factors Z-decay: degradation of maternal mRNAs by zygotically expressed factors	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases			Prader-Willi and Angelman syndromes, including: Angelman syndrome (AS); Prader-Willi syndrome (PWS)
GWAS		Menarche (age at onset) ( 25231870) Red blood cell count ( 32888494)	Cardiac hypertrophy ( 21348951) Gene methylation in lung tissue ( 25713168) Obesity-related traits ( 23251661)
Interacting Genes		42 interacting genes: A1CF ANXA5 ATPAF2 CCDC57 CDKN2D CENPU CIB1 CTBP2 DTX2 EIF1 EIF3A EIF3B EIF3I EIF4A1 EIF4A2 EIF4E EIF5 ENKD1 FXR2 GK HSPB1 HTRA2 HUNK KRT31 KRT34 MKNK1 MKNK2 NCBP1 NCBP2 NTAQ1 PABPC1 PAK2 PDCD4 PEF1 RNF10 SMARCD1 SRPK2 SUMO2 TRAF2 UBE3A UPF2 ZFYVE9	165 interacting genes: ACTA2 ACTB ACTBL2 ACTR3 ADRM1 AFG3L1P AFTPH AHSP ALDH1A2 ANXA1 APP AR ARC ARHGDIB ASAP3 ATG9A BAK1 BARD1 BLK BPY2 BPY2B BPY2C BRCA1 CALR CAPN3 CDK1 CDK4 CDKN1B CEBPZ CGGBP1 CKB CRP CSTPP1 CTNNB1 DAZAP2 DDI2 DLG1 DLG4 E2F1 EAPP EEF1A2 EID1 EIF4G1 EML1 ENO1 ENO2 ESR1 FAF2 GFAP GOPC GTF3C1 HBA1 HPCAL4 HSP90AB1 HSPA2 HSPA4 HSPA5 IL24 JADE1 KLHL38 KRT1 KRT5 KRT7 KRT9 LCK LCN2 MAGEA12 MAGEA8 MAPK1 MAPK10 MARF1 MCM2 MCM4 MCM6 MCM7 MDM1 MDM2 MDM4 MEOX2 MSTO1 MYCBP MYCN NBPF14 NDUFA13 NELFCD NFX1 NHERF1 NOMO2 NR3C1 NR4A3 NUMBL PAICS PARVA PAX5 PAX6 PBRM1 PDE1B PDIA3 PDIA6 PGK1 PGR PKM PML POLE4 PPIA PPP1R3F PRAG1 PRDX1 PRKACA PRMT5 PRSS1 PSAP PTCD3 RAD23A RAD23B RARA RMI1 RNF152 RNF2 RPS15A RYBP SACS SCAMP1 SCRIB SERPINB2 SET SHBG SIPA1L1 SIRT6 SMAD9 SNAPC3 SOD1 SPINK1 SUMO3 TALDO1 TAT TBC1D14 TCF19 TMEM14B TP53 TP53BP2 TRIM65 TSC2 TTC23L TTC3 TUBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2G1 UBE2G2 UBE2L3 UBE2L6 UBE2N UBQLN2 UBR5 WBP2 WDR4 YOD1 YWHAE YWHAG ZNF250 ZNF446
Entrez ID		1981	7337
HPRD ID		06774	03375
Ensembl ID		ENSG00000114867	ENSG00000114062
Uniprot IDs		B2RU06 B2RU10 B4DSI9 O95065 Q04637 Q96I65	A0A6Q8PHE5 Q05086 Q9H2G0
PDB IDs		1LJ2 1UG3 2W97 4AZA 4F02 5EHC 5EI3 5EIR 5T46 5ZK5 6ZMW 8HUJ 8J7R 8OZ0	1C4Z 1D5F 1EQX 2KR1 4GIZ 4XR8 6SJV 6SLM 6TGK 6U19 7Q41 7QPB 8ENP 8EPT 8GCR 8JRN 8JRO 8JRP 8JRQ 8JRR 8R1F 8R1G 9CHT
Enriched GO Terms of Interacting Partners?		Translational Initiation Translation Initiation Factor Activity Cytoplasmic Translational Initiation Post-transcriptional Regulation Of Gene Expression Regulation Of Translation RNA Binding Regulation Of Protein Metabolic Process Regulation Of Translational Initiation RNA Cap Binding Formation Of Cytoplasmic Translation Initiation Complex Eukaryotic 48S Preinitiation Complex Eukaryotic 43S Preinitiation Complex Cytosol Cytoplasm Eukaryotic Translation Initiation Factor 3 Complex, EIF3m Translation Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay MRNA Binding Cytoplasmic Stress Granule Eukaryotic Translation Initiation Factor 4F Complex RNA 7-methylguanosine Cap Binding Eukaryotic Translation Initiation Factor 3 Complex Macromolecule Metabolic Process Protein-RNA Complex Assembly MRNA Transport Regulation Of MRNA Metabolic Process RNA Cap Binding Complex Nuclear Cap Binding Complex Multi-eIF Complex MRNA Export From Nucleus Protein Metabolic Process Protein Binding RNA Transport SnRNA Export From Nucleus Regulation Of Primary Metabolic Process RNA Export From Nucleus Cytoplasmic Ribonucleoprotein Granule Positive Regulation Of MRNA 3'-end Processing Viral Translational Termination-reinitiation Regulation Of Gene Expression Calcium-dependent Protein Serine/threonine Kinase Activity Cap-dependent Translational Initiation Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Nuclear-transcribed MRNA Catabolic Process Regulation Of Metabolic Process Nucleobase-containing Compound Transport Nucleus Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Regulation Of MRNA 3'-end Processing	Cytosol Nucleus Cytoplasm Ubiquitin Protein Ligase Binding Cellular Response To Stress Proteolysis Involved In Protein Catabolic Process Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Ubiquitin-protein Transferase Activity Nucleoplasm Regulation Of Cell Cycle Regulation Of Macromolecule Metabolic Process Response To Stress Protein-containing Complex Proteasomal Protein Catabolic Process Modification-dependent Protein Catabolic Process Regulation Of Mitotic Cell Cycle Extracellular Exosome Ubiquitin-dependent Protein Catabolic Process Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Programmed Cell Death Nuclear Receptor-mediated Signaling Pathway Protein Metabolic Process Regulation Of Gene Expression Regulation Of Apoptotic Process Protein Catabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Post-translational Protein Modification Positive Regulation Of Metabolic Process Macromolecule Metabolic Process Protein Binding Protein Modification By Small Protein Conjugation Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of Programmed Cell Death Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Protein Ubiquitination Positive Regulation Of Biosynthetic Process Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Negative Regulation Of Macromolecule Metabolic Process Macromolecule Catabolic Process Enzyme Binding Identical Protein Binding Regulation Of DNA-templated Transcription
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