EIF4G1 and EIF4A1

Number of citations of the paper that reports this interaction (PMID 9372926)
94

Data Source:
HPRD (in vitro, in vivo)

		EIF4G1	EIF4A1
Gene Name		eukaryotic translation initiation factor 4 gamma, 1	eukaryotic translation initiation factor 4A1
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Gene Ontology Annotations	Cellular Component	Cytosol Membrane Eukaryotic Translation Initiation Factor 4F Complex	Cytosol Membrane Eukaryotic Translation Initiation Factor 4F Complex Extracellular Vesicular Exosome
	Molecular Function	Translation Initiation Factor Activity Protein Binding Translation Factor Activity, Nucleic Acid Binding Poly(A) RNA Binding	RNA Cap Binding Double-stranded RNA Binding MRNA Binding Translation Initiation Factor Activity Helicase Activity Protein Binding ATP Binding Translation Factor Activity, Nucleic Acid Binding Poly(A) RNA Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening Translation Translational Initiation Regulation Of Translational Initiation Insulin Receptor Signaling Pathway Gene Expression Viral Process Cytokine-mediated Signaling Pathway Cellular Protein Metabolic Process	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening Translation Translational Initiation Gene Expression Viral Process Cytokine-mediated Signaling Pathway Organ Regeneration Cellular Protein Metabolic Process
Pathways		Translation initiation complex formation IRS-mediated signalling mTOR signalling S6K1-mediated signalling mTOR signalling mTORC1-mediated signalling AUF1 (hnRNP D0) destabilizes mRNA IGF1R signaling cascade Deadenylation-dependent mRNA decay IRS-related events triggered by IGF1R Eukaryotic Translation Initiation S6K1 signalling Cap-dependent Translation Initiation PKB-mediated events PI3K Cascade Signaling by Insulin receptor Nonsense-Mediated Decay (NMD) Regulation of mRNA stability by proteins that bind AU-rich elements Insulin receptor signalling cascade Deadenylation of mRNA Translation ISG15 antiviral mechanism Interferon Signaling S6K1 signalling Cytokine Signaling in Immune system IRS-related events L13a-mediated translational silencing of Ceruloplasmin expression S6K1-mediated signalling Antiviral mechanism by IFN-stimulated genes mTORC1-mediated signalling Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S PKB-mediated events PI3K Cascade Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	Translation initiation complex formation Translation Deadenylation of mRNA ISG15 antiviral mechanism Interferon Signaling Cytokine Signaling in Immune system L13a-mediated translational silencing of Ceruloplasmin expression Antiviral mechanism by IFN-stimulated genes Deadenylation-dependent mRNA decay Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Initiation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Cap-dependent Translation Initiation
Drugs
Diseases
GWAS
Protein-Protein Interactions		24 interactors: ANXA5 CENPU EIF3A EIF3B EIF3I EIF4A1 EIF4A2 EIF4E EIF5 GK HNRNPD HSPB1 HTRA2 MKNK1 MKNK2 NCBP1 NCBP2 PABPC1 PAK2 PDCD4 TRAF2 UBE3A UPF2 ZFYVE9	10 interactors: EIF4G1 EIF4G2 EIF4G3 LIG4 LPPR4 MAPK6 PAIP1 PRMT1 UCHL5 UPF2
Entrez ID		1981	1973
HPRD ID		06774	04030
Ensembl ID		ENSG00000114867	ENSG00000161960
Uniprot IDs		B2RU06 B2RU10 B4DSI9 E7EUU4 E7EX73 E9PGM1 O95065 Q04637 Q96I65	P60842
PDB IDs		1LJ2 1UG3 2W97 4F02	2G9N 2ZU6 3EIQ
Enriched GO Terms of Interacting Partners?		Regulation Of Translation Regulation Of Translational Initiation Posttranscriptional Regulation Of Gene Expression Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process RNA Catabolic Process Translational Initiation Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process MRNA 3'-end Processing RNA 3'-end Processing Cellular Macromolecule Catabolic Process Aromatic Compound Catabolic Process Nuclear-transcribed MRNA Poly(A) Tail Shortening MRNA Metabolic Process Catabolic Process Viral Process Cellular Macromolecular Complex Assembly Nuclear Export MRNA Processing Regulation Of Gene Expression Translation Nucleocytoplasmic Transport Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear Transport Regulation Of Metabolic Process MRNA Export From Nucleus Ribonucleoprotein Complex Assembly Gene Expression RNA Export From Nucleus RNA Processing Formation Of Translation Preinitiation Complex Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay MRNA Transport RNA Transport Cellular Protein Metabolic Process RNA Localization Ribonucleoprotein Complex Biogenesis Regulation Of Cellular Process Gene Silencing By RNA Protein Metabolic Process Cytoplasmic Transport Cellular Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process MRNA Cis Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of MRNA 3'-end Processing	Translational Initiation Regulation Of Translational Initiation Regulation Of Translation Posttranscriptional Regulation Of Gene Expression Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process Nuclear-transcribed MRNA Poly(A) Tail Shortening RNA Catabolic Process Translation Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Cellular Metabolic Process Cellular Macromolecule Catabolic Process DNA Ligation Involved In DNA Recombination Cellular Protein Metabolic Process MRNA 3'-end Processing Regulation Of Cellular Protein Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Cytokine-mediated Signaling Pathway Aromatic Compound Catabolic Process RNA 3'-end Processing Regulation Of Protein Metabolic Process Gene Expression MRNA Metabolic Process Viral Process Cellular Macromolecule Biosynthetic Process Cellular Response To Cytokine Stimulus Macromolecule Biosynthetic Process Negative Regulation Of Megakaryocyte Differentiation Protein Metabolic Process Lagging Strand Elongation Pro-B Cell Differentiation Response To Cytokine Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine Establishment Of Integrated Proviral Latency Negative Regulation Of Hematopoietic Progenitor Cell Differentiation Immunoglobulin V(D)J Recombination Establishment Of Viral Latency DNA Recombination T Cell Receptor V(D)J Recombination DNA Ligation Involved In DNA Repair Metabolic Process Catabolic Process Lymphoid Progenitor Cell Differentiation Peptidyl-arginine N-methylation Cellular Response To Organic Substance Cell Surface Receptor Signaling Pathway Histone H4-R3 Methylation RNA Metabolic Process DNA Ligation Cellular Response To Stimulus
Tagcloud ?		bioinformatics box burkitt cacgtgt carrying cdk4 chip compelling consensus consequently copyright imidazole interesting k562 leukaemia myc myelogenous owing p493 pi polyamide promoters protected pyrrole qpcr rationale recognizes reserved rights	classes constituents cycling cyclins dexd dysregulation eif4b eif4e helicase helicases impede mcf7 microrna motors oncogenic otherwise pcdc4 pdcd4 polysome preferential quadruplexes ribosome structured translatome ubiquitous unwind unwinding utrs
Tagcloud (Difference) ?		bioinformatics box burkitt cacgtgt carrying cdk4 chip compelling consensus consequently copyright imidazole interesting k562 leukaemia myc myelogenous owing p493 pi polyamide promoters protected pyrrole qpcr rationale recognizes reserved rights	classes constituents cycling cyclins dexd dysregulation eif4b eif4e helicase helicases impede mcf7 microrna motors oncogenic otherwise pcdc4 pdcd4 polysome preferential quadruplexes ribosome structured translatome ubiquitous unwind unwinding utrs
Tagcloud (Intersection) ?