EIF4G1 and EIF5

Number of citations of the paper that reports this interaction (PubMedID 35271311)
106

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, in vitro)

		EIF4G1	EIF5
Description		eukaryotic translation initiation factor 4 gamma 1	eukaryotic translation initiation factor 5
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Ribosome Cytoplasmic Stress Granule Membrane Eukaryotic Translation Initiation Factor 4F Complex	Nucleus Cytoplasm Cytosol Plasma Membrane Synapse
	Molecular Function	RNA Binding MRNA Binding Translation Initiation Factor Activity Protein Binding ATP Binding Translation Factor Activity, RNA Binding Eukaryotic Initiation Factor 4E Binding Translation Initiation Factor Binding Molecular Adaptor Activity	Nucleotide Binding RNA Binding Translation Initiation Factor Activity GDP-dissociation Inhibitor Activity GTPase Activator Activity Protein Binding GTP Binding Cadherin Binding Eukaryotic Initiation Factor EIF2 Binding
	Biological Process	Behavioral Fear Response Cap-dependent Translational Initiation Translation Translational Initiation Regulation Of Translation Regulation Of Translational Initiation Negative Regulation Of Autophagy Neuron Differentiation Positive Regulation Of Cell Growth Cellular Response To Nutrient Levels MiRNA-mediated Gene Silencing By Inhibition Of Translation Positive Regulation Of Translation In Response To Endoplasmic Reticulum Stress Positive Regulation Of Neuron Differentiation Positive Regulation Of Protein Metabolic Process Regulation Of Cellular Response To Stress Energy Homeostasis Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Protein Localization To Cell Periphery Positive Regulation Of Eukaryotic Translation Initiation Factor 4F Complex Assembly Regulation Of Presynapse Assembly	Formation Of Cytoplasmic Translation Initiation Complex Translation Translational Initiation Regulation Of Translational Initiation Ribosome Assembly
Pathways		ISG15 antiviral mechanism L13a-mediated translational silencing of Ceruloplasmin expression mTORC1-mediated signalling Deadenylation of mRNA Deadenylation of mRNA AUF1 (hnRNP D0) binds and destabilizes mRNA Translation initiation complex formation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) M-decay: degradation of maternal mRNAs by maternally stored factors Z-decay: degradation of maternal mRNAs by zygotically expressed factors	Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit
Drugs
Diseases
GWAS		Menarche (age at onset) ( 25231870) Red blood cell count ( 32888494)	Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 26426971) Monocyte count ( 29403010) Number of sexual partners ( 30643258) Red blood cell traits ( 23222517)
Interacting Genes		42 interacting genes: A1CF ANXA5 ATPAF2 CCDC57 CDKN2D CENPU CIB1 CTBP2 DTX2 EIF1 EIF3A EIF3B EIF3I EIF4A1 EIF4A2 EIF4E EIF5 ENKD1 FXR2 GK HSPB1 HTRA2 HUNK KRT31 KRT34 MKNK1 MKNK2 NCBP1 NCBP2 NTAQ1 PABPC1 PAK2 PDCD4 PEF1 RNF10 SMARCD1 SRPK2 SUMO2 TRAF2 UBE3A UPF2 ZFYVE9	18 interacting genes: APP CDC42 CEBPA CSNK2A1 CSNK2B DUSP12 EIF1AX EIF1AY EIF2S2 EIF3D EIF3G EIF4G1 EIF4G2 HSPB1 NCBP2 NRGN OGT PUM1
Entrez ID		1981	1983
HPRD ID		06774	03417
Ensembl ID		ENSG00000114867	ENSG00000100664
Uniprot IDs		B2RU06 B2RU10 B4DSI9 O95065 Q04637 Q96I65	P55010
PDB IDs		1LJ2 1UG3 2W97 4AZA 4F02 5EHC 5EI3 5EIR 5T46 5ZK5 6ZMW 8HUJ 8J7R 8OZ0	2E9H 2G2K 2IU1 8OZ0 8PJ2 8PJ3
Enriched GO Terms of Interacting Partners?		Translational Initiation Translation Initiation Factor Activity Cytoplasmic Translational Initiation Post-transcriptional Regulation Of Gene Expression Regulation Of Translation RNA Binding Regulation Of Protein Metabolic Process Regulation Of Translational Initiation RNA Cap Binding Formation Of Cytoplasmic Translation Initiation Complex Eukaryotic 48S Preinitiation Complex Eukaryotic 43S Preinitiation Complex Cytosol Cytoplasm Eukaryotic Translation Initiation Factor 3 Complex, EIF3m Translation Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay MRNA Binding Cytoplasmic Stress Granule Eukaryotic Translation Initiation Factor 4F Complex RNA 7-methylguanosine Cap Binding Eukaryotic Translation Initiation Factor 3 Complex Macromolecule Metabolic Process Protein-RNA Complex Assembly MRNA Transport Regulation Of MRNA Metabolic Process RNA Cap Binding Complex Nuclear Cap Binding Complex Multi-eIF Complex MRNA Export From Nucleus Protein Metabolic Process Protein Binding RNA Transport SnRNA Export From Nucleus Regulation Of Primary Metabolic Process RNA Export From Nucleus Cytoplasmic Ribonucleoprotein Granule Positive Regulation Of MRNA 3'-end Processing Viral Translational Termination-reinitiation Regulation Of Gene Expression Calcium-dependent Protein Serine/threonine Kinase Activity Cap-dependent Translational Initiation Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Nuclear-transcribed MRNA Catabolic Process Regulation Of Metabolic Process Nucleobase-containing Compound Transport Nucleus Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Regulation Of MRNA 3'-end Processing	Translational Initiation Translation Initiation Factor Activity Cytoplasmic Translational Initiation Regulation Of Translational Initiation Translation Regulation Of Translation Translation Factor Activity, RNA Binding Cap-dependent Translational Initiation Post-transcriptional Regulation Of Gene Expression Macromolecule Biosynthetic Process Regulation Of Protein Metabolic Process Cytosol RNA Binding Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Protein Metabolic Process Viral Translational Termination-reinitiation Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Macromolecule Metabolic Process Positive Regulation Of Cell Growth Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process Regulation Of Proteolysis Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Catabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cell Cycle Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Eukaryotic Translation Initiation Factor 4F Complex Formation Of Cytoplasmic Translation Initiation Complex Eukaryotic Translation Initiation Factor 3 Complex Positive Regulation Of Growth MRNA Binding Regulation Of Synapse Organization Sin3-type Complex Translation Initiation Factor Binding Positive Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Protein Catabolic Process Cellular Component Assembly Regulation Of Growth Regulation Of Presynapse Organization Regulation Of Presynapse Assembly PcG Protein Complex Post-transcriptional Gene Silencing Negative Regulation Of Proteolysis Viral Process
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