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EIF4G1 and PAK2
Number of citations of the paper that reports this interaction (PubMedID
16281055
)
37
Data Source:
HPRD
(in vivo)
EIF4G1
PAK2
Description
eukaryotic translation initiation factor 4 gamma 1
p21 (RAC1) activated kinase 2
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Cytosol
Ribosome
Cytoplasmic Stress Granule
Membrane
Eukaryotic Translation Initiation Factor 4F Complex
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Plasma Membrane
Cell-cell Junction
Focal Adhesion
Postsynaptic Density
Membrane
Nuclear Speck
Secretory Granule
Perinuclear Region Of Cytoplasm
Glutamatergic Synapse
Molecular Function
RNA Binding
MRNA Binding
Translation Initiation Factor Activity
Protein Binding
ATP Binding
Translation Factor Activity, RNA Binding
Eukaryotic Initiation Factor 4E Binding
Translation Initiation Factor Binding
Molecular Adaptor Activity
Nucleotide Binding
Catalytic Activity
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Protein Kinase Binding
Protein Tyrosine Kinase Activator Activity
Small GTPase Binding
Identical Protein Binding
Cadherin Binding
Protein Serine Kinase Activity
Biological Process
Behavioral Fear Response
Cap-dependent Translational Initiation
Translation
Translational Initiation
Regulation Of Translation
Regulation Of Translational Initiation
Negative Regulation Of Autophagy
Neuron Differentiation
Positive Regulation Of Cell Growth
Cellular Response To Nutrient Levels
MiRNA-mediated Gene Silencing By Inhibition Of Translation
Positive Regulation Of Translation In Response To Endoplasmic Reticulum Stress
Positive Regulation Of Neuron Differentiation
Positive Regulation Of Protein Metabolic Process
Regulation Of Cellular Response To Stress
Energy Homeostasis
Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle
Positive Regulation Of Protein Localization To Cell Periphery
Positive Regulation Of Eukaryotic Translation Initiation Factor 4F Complex Assembly
Regulation Of Presynapse Assembly
Stimulatory C-type Lectin Receptor Signaling Pathway
Cardiac Muscle Hypertrophy
Protein Phosphorylation
Negative Regulation Of Protein Kinase Activity
Apoptotic Process
Signal Transduction
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Cellular Response To Starvation
Cell Migration
Adherens Junction Assembly
Intracellular Signal Transduction
Negative Regulation Of Apoptotic Process
Regulation Of MAPK Cascade
Protein Autophosphorylation
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Regulation Of Axonogenesis
Regulation Of Cytoskeleton Organization
Negative Regulation Of Stress Fiber Assembly
Protein Maturation
Dendritic Spine Development
Bicellular Tight Junction Assembly
Cellular Response To Transforming Growth Factor Beta Stimulus
Execution Phase Of Apoptosis
Regulation Of Actin Filament Organization
Protein Localization To Cell-cell Junction
Positive Regulation Of Execution Phase Of Apoptosis
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways
ISG15 antiviral mechanism
L13a-mediated translational silencing of Ceruloplasmin expression
mTORC1-mediated signalling
Deadenylation of mRNA
Deadenylation of mRNA
AUF1 (hnRNP D0) binds and destabilizes mRNA
Translation initiation complex formation
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Ribosomal scanning and start codon recognition
GTP hydrolysis and joining of the 60S ribosomal subunit
Regulation of expression of SLITs and ROBOs
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
M-decay: degradation of maternal mRNAs by maternally stored factors
Z-decay: degradation of maternal mRNAs by zygotically expressed factors
Nef and signal transduction
Generation of second messenger molecules
Regulation of PAK-2p34 activity by PS-GAP/RHG10
Regulation of activated PAK-2p34 by proteasome mediated degradation
Stimulation of the cell death response by PAK-2p34
FCERI mediated MAPK activation
FCERI mediated MAPK activation
CD28 dependent Vav1 pathway
Ephrin signaling
Sema3A PAK dependent Axon repulsion
Activation of RAC1
VEGFA-VEGFR2 Pathway
Smooth Muscle Contraction
VEGFR2 mediated vascular permeability
CD209 (DC-SIGN) signaling
RHO GTPases activate PAKs
RHO GTPases activate PAKs
MAPK6/MAPK4 signaling
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
CDC42 GTPase cycle
RAC1 GTPase cycle
RAC2 GTPase cycle
RHOQ GTPase cycle
RHOH GTPase cycle
RHOG GTPase cycle
RHOJ GTPase cycle
RHOU GTPase cycle
RAC3 GTPase cycle
RHOV GTPase cycle
Drugs
Fostamatinib
Diseases
GWAS
Menarche (age at onset) (
25231870
)
Red blood cell count (
32888494
)
Asthma (
31959851
)
Atrial fibrillation (
29892015
)
Eosinophil count (
32888494
27863252
)
Glucose homeostasis traits (
25524916
)
Lymphocyte count (
27863252
32888494
)
Malaria (
31844061
)
Mean corpuscular hemoglobin concentration (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Monocyte count (
27863252
32888494
)
Neutrophil count (
32888494
)
Platelet count (
27863252
32888494
)
Platelet distribution width (
32888494
)
Plateletcrit (
27863252
32888494
)
Red cell distribution width (
32888494
)
Reticulocyte fraction of red cells (
32888494
)
Sum eosinophil basophil counts (
27863252
)
Total ventricular volume (Alzheimer's disease interaction) (
21116278
)
White blood cell count (
27863252
32888494
)
Interacting Genes
42 interacting genes:
A1CF
ANXA5
ATPAF2
CCDC57
CDKN2D
CENPU
CIB1
CTBP2
DTX2
EIF1
EIF3A
EIF3B
EIF3I
EIF4A1
EIF4A2
EIF4E
EIF5
ENKD1
FXR2
GK
HSPB1
HTRA2
HUNK
KRT31
KRT34
MKNK1
MKNK2
NCBP1
NCBP2
NTAQ1
PABPC1
PAK2
PDCD4
PEF1
RNF10
SMARCD1
SRPK2
SUMO2
TRAF2
UBE3A
UPF2
ZFYVE9
54 interacting genes:
ABI1
ABI2
ABI3
ABL1
APP
ARHGAP10
ARHGEF6
ARHGEF7
BRAF
CASP3
CDC42
CEBPA
DOCK2
DSCR9
DST
EIF4B
EIF4G1
EP300
FYN
GRB2
H4C6
HCK
LCK
LIMK1
LYN
MAPK1
MAPK3
MKNK1
MYC
MYL2
MYLK
NCK1
NPHP1
OGT
PACSIN3
PPM1A
RAC1
RAF1
RIOK3
RPS6
SH3GL2
SH3KBP1
SH3PXD2A
SH3RF1
SH3RF3
SNX33
SNX9
SORBS1
SORBS2
SORBS3
SRC
SYN1
VIM
YES1
Entrez ID
1981
5062
HPRD ID
06774
05428
Ensembl ID
ENSG00000114867
ENSG00000180370
Uniprot IDs
B2RU06
B2RU10
B4DSI9
O95065
Q04637
Q96I65
A8K5M4
Q13177
PDB IDs
1LJ2
1UG3
2W97
4AZA
4F02
5EHC
5EI3
5EIR
5T46
5ZK5
6ZMW
8HUJ
8J7R
8OZ0
3PCS
Enriched GO Terms of Interacting Partners
?
Translational Initiation
Translation Initiation Factor Activity
Cytoplasmic Translational Initiation
Post-transcriptional Regulation Of Gene Expression
Regulation Of Translation
RNA Binding
Regulation Of Protein Metabolic Process
Regulation Of Translational Initiation
RNA Cap Binding
Formation Of Cytoplasmic Translation Initiation Complex
Eukaryotic 48S Preinitiation Complex
Eukaryotic 43S Preinitiation Complex
Cytosol
Cytoplasm
Eukaryotic Translation Initiation Factor 3 Complex, EIF3m
Translation
Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay
MRNA Binding
Cytoplasmic Stress Granule
Eukaryotic Translation Initiation Factor 4F Complex
RNA 7-methylguanosine Cap Binding
Eukaryotic Translation Initiation Factor 3 Complex
Macromolecule Metabolic Process
Protein-RNA Complex Assembly
MRNA Transport
Regulation Of MRNA Metabolic Process
RNA Cap Binding Complex
Nuclear Cap Binding Complex
Multi-eIF Complex
MRNA Export From Nucleus
Protein Metabolic Process
Protein Binding
RNA Transport
SnRNA Export From Nucleus
Regulation Of Primary Metabolic Process
RNA Export From Nucleus
Cytoplasmic Ribonucleoprotein Granule
Positive Regulation Of MRNA 3'-end Processing
Viral Translational Termination-reinitiation
Regulation Of Gene Expression
Calcium-dependent Protein Serine/threonine Kinase Activity
Cap-dependent Translational Initiation
Regulation Of Macromolecule Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Nuclear-transcribed MRNA Catabolic Process
Regulation Of Metabolic Process
Nucleobase-containing Compound Transport
Nucleus
Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay
Regulation Of MRNA 3'-end Processing
Regulation Of Cellular Component Organization
Cytosol
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Intracellular Signal Transduction
Regulation Of Vesicle-mediated Transport
Cytoskeleton Organization
Positive Regulation Of Cellular Component Organization
Fc-gamma Receptor Signaling Pathway
Positive Regulation Of Supramolecular Fiber Organization
Cytoplasm
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Enzyme-linked Receptor Protein Signaling Pathway
Immune Response-activating Cell Surface Receptor Signaling Pathway
Fc Receptor Mediated Stimulatory Signaling Pathway
Regulation Of MAPK Cascade
Focal Adhesion
Protein Phosphorylation
Ephrin Receptor Binding
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Peptidyl-tyrosine Phosphorylation
Organelle Organization
Regulation Of Protein Metabolic Process
Intracellular Signaling Cassette
Fc Receptor Signaling Pathway
Phosphorylation
Positive Regulation Of Cytoskeleton Organization
Signal Transduction
Anchoring Junction
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Organelle Organization
Cell Surface Receptor Signaling Pathway
Regulation Of Protein-containing Complex Assembly
Immune Response-activating Signaling Pathway
Actin Cytoskeleton Organization
Non-membrane Spanning Protein Tyrosine Kinase Activity
Endocytosis
Regulation Of Cell Activation
Regulation Of Transport
Regulation Of Immune System Process
Positive Regulation Of Immune System Process
Phosphotyrosine Residue Binding
Regulation Of Supramolecular Fiber Organization
Regulation Of Endocytosis
Regulation Of T Cell Activation
Ephrin Receptor Signaling Pathway
Regulation Of Intracellular Signal Transduction
Supramolecular Fiber Organization
Actin Filament-based Process
Protein Kinase Activity
Lamellipodium
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Tagcloud (Intersection)
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