EIF4G1 and NCBP1

Number of citations of the paper that reports this interaction (PMID 11340157)
38

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		EIF4G1	NCBP1
Gene Name		eukaryotic translation initiation factor 4 gamma, 1	nuclear cap binding protein subunit 1, 80kDa
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Gene Ontology Annotations	Cellular Component	Cytosol Membrane Eukaryotic Translation Initiation Factor 4F Complex	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol MRNA Cap Binding Complex Nuclear Cap Binding Complex Ribonucleoprotein Complex
	Molecular Function	Translation Initiation Factor Activity Protein Binding Translation Factor Activity, Nucleic Acid Binding Poly(A) RNA Binding	RNA Cap Binding RNA Binding Protein Binding Poly(A) RNA Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening Translation Translational Initiation Regulation Of Translational Initiation Insulin Receptor Signaling Pathway Gene Expression Viral Process Cytokine-mediated Signaling Pathway Cellular Protein Metabolic Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Spliceosomal SnRNP Assembly MRNA Splicing, Via Spliceosome Transcription From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter Termination Of RNA Polymerase II Transcription 7-methylguanosine MRNA Capping MRNA Cleavage MRNA Export From Nucleus Regulation Of Translational Initiation Histone MRNA Metabolic Process RNA Splicing Gene Expression Viral Process Gene Silencing By RNA MRNA 3'-end Processing Positive Regulation Of MRNA 3'-end Processing NcRNA Metabolic Process MRNA Cis Splicing, Via Spliceosome Positive Regulation Of Viral Transcription
Pathways		Translation initiation complex formation IRS-mediated signalling mTOR signalling S6K1-mediated signalling mTOR signalling mTORC1-mediated signalling AUF1 (hnRNP D0) destabilizes mRNA IGF1R signaling cascade Deadenylation-dependent mRNA decay IRS-related events triggered by IGF1R Eukaryotic Translation Initiation S6K1 signalling Cap-dependent Translation Initiation PKB-mediated events PI3K Cascade Signaling by Insulin receptor Nonsense-Mediated Decay (NMD) Regulation of mRNA stability by proteins that bind AU-rich elements Insulin receptor signalling cascade Deadenylation of mRNA Translation ISG15 antiviral mechanism Interferon Signaling S6K1 signalling Cytokine Signaling in Immune system IRS-related events L13a-mediated translational silencing of Ceruloplasmin expression S6K1-mediated signalling Antiviral mechanism by IFN-stimulated genes mTORC1-mediated signalling Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S PKB-mediated events PI3K Cascade Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	mRNA Splicing Formation of HIV-1 elongation complex containing HIV-1 Tat RNA Polymerase II Transcription Abortive elongation of HIV-1 transcript in the absence of Tat HIV Infection Formation of the Early Elongation Complex Transport of the SLBP independent Mature mRNA Tat-mediated elongation of the HIV-1 transcript Cleavage of Growing Transcript in the Termination Region Processing of Intronless Pre-mRNAs RNA Polymerase II Pre-transcription Events SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs HIV Life Cycle Transport of Mature Transcript to Cytoplasm HIV Transcription Elongation SLBP independent Processing of Histone Pre-mRNAs Nonsense-Mediated Decay (NMD) Transport of Mature mRNA Derived from an Intronless Transcript Processing of Capped Intron-Containing Pre-mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Capping Transport of Mature mRNAs Derived from Intronless Transcripts mRNA Splicing - Minor Pathway Metabolism of non-coding RNA mRNA Splicing - Major Pathway mRNA 3'-end processing Late Phase of HIV Life Cycle Formation of RNA Pol II elongation complex Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) snRNP Assembly Formation of HIV elongation complex in the absence of HIV Tat Processing of Capped Intronless Pre-mRNA Formation of the HIV-1 Early Elongation Complex RNA Polymerase II Transcription Termination Transcription of the HIV genome Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS			Thyroid cancer (Papillary, radiation-related) ( 20350937)
Protein-Protein Interactions		24 interactors: ANXA5 CENPU EIF3A EIF3B EIF3I EIF4A1 EIF4A2 EIF4E EIF5 GK HNRNPD HSPB1 HTRA2 MKNK1 MKNK2 NCBP1 NCBP2 PABPC1 PAK2 PDCD4 TRAF2 UBE3A UPF2 ZFYVE9	14 interactors: BNIP1 BNIP2 BNIP3 C17orf85 EIF4G1 EIF4G2 HNRNPF HNRNPH1 NCBP2 RNF40 RPS6KB1 SNRPA1 STAU1 ZDHHC17
Entrez ID		1981	4686
HPRD ID		06774	02717
Ensembl ID		ENSG00000114867	ENSG00000136937
Uniprot IDs		B2RU06 B2RU10 B4DSI9 E7EUU4 E7EX73 E9PGM1 O95065 Q04637 Q96I65	Q09161
PDB IDs		1LJ2 1UG3 2W97 4F02	1H2T 1H2U 1H2V 1H6K 1N52 1N54 3FEX 3FEY
Enriched GO Terms of Interacting Partners?		Regulation Of Translation Regulation Of Translational Initiation Posttranscriptional Regulation Of Gene Expression Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process RNA Catabolic Process Translational Initiation Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process MRNA 3'-end Processing RNA 3'-end Processing Cellular Macromolecule Catabolic Process Aromatic Compound Catabolic Process Nuclear-transcribed MRNA Poly(A) Tail Shortening MRNA Metabolic Process Catabolic Process Viral Process Cellular Macromolecular Complex Assembly Nuclear Export MRNA Processing Regulation Of Gene Expression Translation Nucleocytoplasmic Transport Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear Transport Regulation Of Metabolic Process MRNA Export From Nucleus Ribonucleoprotein Complex Assembly Gene Expression RNA Export From Nucleus RNA Processing Formation Of Translation Preinitiation Complex Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay MRNA Transport RNA Transport Cellular Protein Metabolic Process RNA Localization Ribonucleoprotein Complex Biogenesis Regulation Of Cellular Process Gene Silencing By RNA Protein Metabolic Process Cytoplasmic Transport Cellular Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process MRNA Cis Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of MRNA 3'-end Processing	Regulation Of Translational Initiation MRNA Processing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions MRNA Metabolic Process RNA Processing Regulation Of Translation RNA Splicing Posttranscriptional Regulation Of Gene Expression Cell Death Death Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia Positive Regulation Of Viral Process MRNA 3'-end Processing Cellular Macromolecule Catabolic Process Endoplasmic Reticulum Membrane Fusion SnRNA Export From Nucleus Positive Regulation Of RNA Export From Nucleus Positive Regulation Of Skeletal Muscle Tissue Growth Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Regulation Of RNA Splicing Apoptotic Process Negative Regulation Of Cell Death RNA 3'-end Processing Positive Regulation By Virus Of Viral Protein Levels In Host Cell Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Mitochondrial Protein Catabolic Process Programmed Cell Death Catabolic Process Cellular Metabolic Process Skeletal Muscle Atrophy Negative Regulation Of Mitochondrial Fusion Granzyme-mediated Apoptotic Signaling Pathway Nuclear-transcribed MRNA Catabolic Process Viral Process RNA Localization Insulin Receptor Signaling Pathway Autophagic Cell Death Striated Muscle Atrophy Response To Leucine Regulation Of Mitochondrial Fusion Regulation Of Viral Process MRNA Catabolic Process Cellular Response To Cobalt Ion Muscle Atrophy RNA Catabolic Process Skeletal Muscle Adaptation Histone H2B Ubiquitination
Tagcloud ?		bioinformatics box burkitt cacgtgt carrying cdk4 chip compelling consensus consequently copyright imidazole interesting k562 leukaemia myc myelogenous owing p493 pi polyamide promoters protected pyrrole qpcr rationale recognizes reserved rights	adaptation cdna delayed elicited equivalent fundamental heat implicates ischaemia ischaemic isoform lethal mediating modulating myocardium pp2 preconditioning rabbit rda rendered reperfusion representational salvage se sham shock tgfbeta trip1 ventricle
Tagcloud (Difference) ?		bioinformatics box burkitt cacgtgt carrying cdk4 chip compelling consensus consequently copyright imidazole interesting k562 leukaemia myc myelogenous owing p493 pi polyamide promoters protected pyrrole qpcr rationale recognizes reserved rights	adaptation cdna delayed elicited equivalent fundamental heat implicates ischaemia ischaemic isoform lethal mediating modulating myocardium pp2 preconditioning rabbit rda rendered reperfusion representational salvage se sham shock tgfbeta trip1 ventricle
Tagcloud (Intersection) ?