EIF4G1 and EIF1

Number of citations of the paper that reports this interaction (PubMedID 29987188)
45

Data Source:
BioGRID (protein complementation assay)

		EIF4G1	EIF1
Description		eukaryotic translation initiation factor 4 gamma 1	eukaryotic translation initiation factor 1
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Ribosome Cytoplasmic Stress Granule Membrane Eukaryotic Translation Initiation Factor 4F Complex	Nucleus Cytoplasm Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex Multi-eIF Complex
	Molecular Function	RNA Binding MRNA Binding Translation Initiation Factor Activity Protein Binding ATP Binding Translation Factor Activity, RNA Binding Eukaryotic Initiation Factor 4E Binding Translation Initiation Factor Binding Molecular Adaptor Activity	RNA Binding Translation Initiation Factor Activity Protein Binding Translation Factor Activity, RNA Binding Ribosomal Small Subunit Binding
	Biological Process	Behavioral Fear Response Cap-dependent Translational Initiation Translation Translational Initiation Regulation Of Translation Regulation Of Translational Initiation Negative Regulation Of Autophagy Neuron Differentiation Positive Regulation Of Cell Growth Cellular Response To Nutrient Levels MiRNA-mediated Gene Silencing By Inhibition Of Translation Positive Regulation Of Translation In Response To Endoplasmic Reticulum Stress Positive Regulation Of Neuron Differentiation Positive Regulation Of Protein Metabolic Process Regulation Of Cellular Response To Stress Energy Homeostasis Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Protein Localization To Cell Periphery Positive Regulation Of Eukaryotic Translation Initiation Factor 4F Complex Assembly Regulation Of Presynapse Assembly	Translation Translational Initiation Regulation Of Translational Initiation Regulation Of Gene Expression Regulation Of Primary Metabolic Process
Pathways		ISG15 antiviral mechanism L13a-mediated translational silencing of Ceruloplasmin expression mTORC1-mediated signalling Deadenylation of mRNA Deadenylation of mRNA AUF1 (hnRNP D0) binds and destabilizes mRNA Translation initiation complex formation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) M-decay: degradation of maternal mRNAs by maternally stored factors Z-decay: degradation of maternal mRNAs by zygotically expressed factors
Drugs
Diseases
GWAS		Menarche (age at onset) ( 25231870) Red blood cell count ( 32888494)
Interacting Genes		42 interacting genes: A1CF ANXA5 ATPAF2 CCDC57 CDKN2D CENPU CIB1 CTBP2 DTX2 EIF1 EIF3A EIF3B EIF3I EIF4A1 EIF4A2 EIF4E EIF5 ENKD1 FXR2 GK HSPB1 HTRA2 HUNK KRT31 KRT34 MKNK1 MKNK2 NCBP1 NCBP2 NTAQ1 PABPC1 PAK2 PDCD4 PEF1 RNF10 SMARCD1 SRPK2 SUMO2 TRAF2 UBE3A UPF2 ZFYVE9	9 interacting genes: APP CEBPA EIF4G1 HMGB1 HMGB2 MAPK6 OLFM2 RASA1 UPF2
Entrez ID		1981	10209
HPRD ID		06774	15449
Ensembl ID		ENSG00000114867	ENSG00000173812
Uniprot IDs		B2RU06 B2RU10 B4DSI9 O95065 Q04637 Q96I65	P41567 Q6IAV3
PDB IDs		1LJ2 1UG3 2W97 4AZA 4F02 5EHC 5EI3 5EIR 5T46 5ZK5 6ZMW 8HUJ 8J7R 8OZ0	2IF1 4KZX 4KZY 6YBW 6ZMW 6ZP4 6ZVJ 7A09 7QP6 8PJ1 8PPK 8PPL 8XXN 9BLN
Enriched GO Terms of Interacting Partners?		Translational Initiation Translation Initiation Factor Activity Cytoplasmic Translational Initiation Post-transcriptional Regulation Of Gene Expression Regulation Of Translation RNA Binding Regulation Of Protein Metabolic Process Regulation Of Translational Initiation RNA Cap Binding Formation Of Cytoplasmic Translation Initiation Complex Eukaryotic 48S Preinitiation Complex Eukaryotic 43S Preinitiation Complex Cytosol Cytoplasm Eukaryotic Translation Initiation Factor 3 Complex, EIF3m Translation Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay MRNA Binding Cytoplasmic Stress Granule Eukaryotic Translation Initiation Factor 4F Complex RNA 7-methylguanosine Cap Binding Eukaryotic Translation Initiation Factor 3 Complex Macromolecule Metabolic Process Protein-RNA Complex Assembly MRNA Transport Regulation Of MRNA Metabolic Process RNA Cap Binding Complex Nuclear Cap Binding Complex Multi-eIF Complex MRNA Export From Nucleus Protein Metabolic Process Protein Binding RNA Transport SnRNA Export From Nucleus Regulation Of Primary Metabolic Process RNA Export From Nucleus Cytoplasmic Ribonucleoprotein Granule Positive Regulation Of MRNA 3'-end Processing Viral Translational Termination-reinitiation Regulation Of Gene Expression Calcium-dependent Protein Serine/threonine Kinase Activity Cap-dependent Translational Initiation Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Nuclear-transcribed MRNA Catabolic Process Regulation Of Metabolic Process Nucleobase-containing Compound Transport Nucleus Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Regulation Of MRNA 3'-end Processing	RAGE Receptor Binding Chemoattractant Activity Positive Regulation Of Developmental Process Regulation Of Developmental Process Positive Chemotaxis Positive Regulation Of Cell Differentiation Supercoiled DNA Binding DNA Geometric Change DNA Topological Change Regulation Of Cell Differentiation DNA Binding, Bending DNA Conformation Change Four-way Junction DNA Binding V(D)J Recombination Positive Regulation Of Defense Response Positive Regulation Of Monocyte Chemotaxis Regulation Of Presynapse Organization Regulation Of Presynapse Assembly DNA-binding Transcription Factor Binding Negative Regulation Of Gene Expression Regulation Of Monocyte Chemotaxis Inflammatory Response To Antigenic Stimulus Condensed Chromosome Response To Steroid Hormone Positive Regulation Of Gene Expression Positive Regulation Of Interferon-beta Production Somatic Cell DNA Recombination Negative Regulation Of Macromolecule Biosynthetic Process Transcription Cis-regulatory Region Binding Defense Response Negative Regulation Of Biosynthetic Process Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of Carbohydrate Catabolic Process Macrophage Activation Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Interleukin-1 Beta Production Protein-containing Complex Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Animal Organ Regeneration RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Eukaryotic Translation Initiation Factor 4F Complex Assembly Calcium-dependent Protein Kinase Regulator Activity Regulation Of Restriction Endodeoxyribonuclease Activity Damaged DNA Binding Positive Regulation Of Myeloid Progenitor Cell Differentiation Double-strand Break Repair Via Nonhomologous End Joining Regulation Of Interferon-beta Production
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