EIF4G1 and MKNK2

Number of citations of the paper that reports this interaction (PubMedID 12897141)
49

Data Source:
BioGRID (enzymatic study)

		EIF4G1	MKNK2
Description		eukaryotic translation initiation factor 4 gamma 1	MAPK interacting serine/threonine kinase 2
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Ribosome Cytoplasmic Stress Granule Membrane Eukaryotic Translation Initiation Factor 4F Complex	Nucleus Nucleoplasm Cytoplasm Nuclear Body PML Body
	Molecular Function	RNA Binding MRNA Binding Translation Initiation Factor Activity Protein Binding ATP Binding Translation Factor Activity, RNA Binding Eukaryotic Initiation Factor 4E Binding Translation Initiation Factor Binding Molecular Adaptor Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Calcium/calmodulin-dependent Protein Kinase Activity Protein Binding Calmodulin Binding ATP Binding Calcium-dependent Protein Serine/threonine Kinase Activity Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Behavioral Fear Response Cap-dependent Translational Initiation Translation Translational Initiation Regulation Of Translation Regulation Of Translational Initiation Negative Regulation Of Autophagy Neuron Differentiation Positive Regulation Of Cell Growth Cellular Response To Nutrient Levels MiRNA-mediated Gene Silencing By Inhibition Of Translation Positive Regulation Of Translation In Response To Endoplasmic Reticulum Stress Positive Regulation Of Neuron Differentiation Positive Regulation Of Protein Metabolic Process Regulation Of Cellular Response To Stress Energy Homeostasis Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Protein Localization To Cell Periphery Positive Regulation Of Eukaryotic Translation Initiation Factor 4F Complex Assembly Regulation Of Presynapse Assembly	Regulation Of Translation Protein Phosphorylation Apoptotic Process Cell Surface Receptor Signaling Pathway Hemopoiesis Intracellular Signal Transduction Cellular Response To Arsenic-containing Substance Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		ISG15 antiviral mechanism L13a-mediated translational silencing of Ceruloplasmin expression mTORC1-mediated signalling Deadenylation of mRNA Deadenylation of mRNA AUF1 (hnRNP D0) binds and destabilizes mRNA Translation initiation complex formation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) M-decay: degradation of maternal mRNAs by maternally stored factors Z-decay: degradation of maternal mRNAs by zygotically expressed factors
Drugs			Fostamatinib
Diseases
GWAS		Menarche (age at onset) ( 25231870) Red blood cell count ( 32888494)	Nonsyndromic cleft lip with or without cleft palate ( 28087736)
Interacting Genes		42 interacting genes: A1CF ANXA5 ATPAF2 CCDC57 CDKN2D CENPU CIB1 CTBP2 DTX2 EIF1 EIF3A EIF3B EIF3I EIF4A1 EIF4A2 EIF4E EIF5 ENKD1 FXR2 GK HSPB1 HTRA2 HUNK KRT31 KRT34 MKNK1 MKNK2 NCBP1 NCBP2 NTAQ1 PABPC1 PAK2 PDCD4 PEF1 RNF10 SMARCD1 SRPK2 SUMO2 TRAF2 UBE3A UPF2 ZFYVE9	13 interacting genes: CUL2 EIF4E EIF4G1 ESR1 ESR2 MAPK1 MAPK14 MAPK8 MESD PSMA1 RBX1 RPL7A VBP1
Entrez ID		1981	2872
HPRD ID		06774	05459
Ensembl ID		ENSG00000114867	ENSG00000099875
Uniprot IDs		B2RU06 B2RU10 B4DSI9 O95065 Q04637 Q96I65	B3KS07 Q9HBH9
PDB IDs		1LJ2 1UG3 2W97 4AZA 4F02 5EHC 5EI3 5EIR 5T46 5ZK5 6ZMW 8HUJ 8J7R 8OZ0	2AC3 2AC5 2HW7 6CJ5 6CJE 6CJH 6CJW 6CJY 6CK3 6CK6 6CKI 6JLR 8P9B 8XFM 9HRC
Enriched GO Terms of Interacting Partners?		Translational Initiation Translation Initiation Factor Activity Cytoplasmic Translational Initiation Post-transcriptional Regulation Of Gene Expression Regulation Of Translation RNA Binding Regulation Of Protein Metabolic Process Regulation Of Translational Initiation RNA Cap Binding Formation Of Cytoplasmic Translation Initiation Complex Eukaryotic 48S Preinitiation Complex Eukaryotic 43S Preinitiation Complex Cytosol Cytoplasm Eukaryotic Translation Initiation Factor 3 Complex, EIF3m Translation Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay MRNA Binding Cytoplasmic Stress Granule Eukaryotic Translation Initiation Factor 4F Complex RNA 7-methylguanosine Cap Binding Eukaryotic Translation Initiation Factor 3 Complex Macromolecule Metabolic Process Protein-RNA Complex Assembly MRNA Transport Regulation Of MRNA Metabolic Process RNA Cap Binding Complex Nuclear Cap Binding Complex Multi-eIF Complex MRNA Export From Nucleus Protein Metabolic Process Protein Binding RNA Transport SnRNA Export From Nucleus Regulation Of Primary Metabolic Process RNA Export From Nucleus Cytoplasmic Ribonucleoprotein Granule Positive Regulation Of MRNA 3'-end Processing Viral Translational Termination-reinitiation Regulation Of Gene Expression Calcium-dependent Protein Serine/threonine Kinase Activity Cap-dependent Translational Initiation Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Nuclear-transcribed MRNA Catabolic Process Regulation Of Metabolic Process Nucleobase-containing Compound Transport Nucleus Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Regulation Of MRNA 3'-end Processing	MAP Kinase Activity Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Nuclear Estrogen Receptor Activity Enzyme Binding Cellular Response To Lipid Response To Lipid Cellular Response To Amino Acid Starvation Response To Amino Acid Starvation Response To Nutrient Levels Cellular Response To Oxygen-containing Compound MAPK Cascade Energy Homeostasis Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Cellular Response To Nutrient Levels Estrogen Response Element Binding Ubiquitin-dependent Protein Catabolic Process Via The C-end Degron Rule Pathway Eukaryotic Translation Initiation Factor 4F Complex Protein Metabolic Process Post-transcriptional Regulation Of Gene Expression Cullin-RING Ubiquitin Ligase Complex Nucleus Negative Regulation Of Autophagy Mammary Gland Epithelial Cell Proliferation Cul2-RING Ubiquitin Ligase Complex Positive Regulation Of Cyclase Activity Cytosol Nuclear Steroid Receptor Activity Peptidyl-threonine Phosphorylation Intracellular Signal Transduction Negative Regulation Of Catabolic Process Regulation Of Autophagy Estrogen Receptor Signaling Pathway Negative Regulation Of Macromolecule Metabolic Process P38MAPK Cascade Mitotic Cell Cycle Phase Transition Response To UV Steroid Binding Regulation Of Inflammatory Response Cell Cycle Phase Transition Negative Regulation Of Inflammatory Response To Antigenic Stimulus Negative Regulation Of Metabolic Process Canonical Inflammasome Complex Assembly Behavioral Fear Response Behavioral Defense Response Cellular Response To Estradiol Stimulus Cellular Response To Starvation Regulation Of MRNA Stability Macromolecule Metabolic Process
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