EIF4G1 and EIF3B

Number of citations of the paper that reports this interaction (PubMedID 16541103)
38

Data Source:
HPRD (in vivo)

		EIF4G1	EIF3B
Description		eukaryotic translation initiation factor 4 gamma 1	eukaryotic translation initiation factor 3 subunit B
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Ribosome Cytoplasmic Stress Granule Membrane Eukaryotic Translation Initiation Factor 4F Complex	Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 3 Complex Cytoplasmic Stress Granule Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex Synapse Extracellular Exosome Eukaryotic Translation Initiation Factor 3 Complex, EIF3m
	Molecular Function	RNA Binding MRNA Binding Translation Initiation Factor Activity Protein Binding ATP Binding Translation Factor Activity, RNA Binding Eukaryotic Initiation Factor 4E Binding Translation Initiation Factor Binding Molecular Adaptor Activity	Nucleic Acid Binding RNA Binding Translation Initiation Factor Activity Protein Binding Translation Initiation Factor Binding Molecular Adaptor Activity
	Biological Process	Behavioral Fear Response Cap-dependent Translational Initiation Translation Translational Initiation Regulation Of Translation Regulation Of Translational Initiation Negative Regulation Of Autophagy Neuron Differentiation Positive Regulation Of Cell Growth Cellular Response To Nutrient Levels MiRNA-mediated Gene Silencing By Inhibition Of Translation Positive Regulation Of Translation In Response To Endoplasmic Reticulum Stress Positive Regulation Of Neuron Differentiation Positive Regulation Of Protein Metabolic Process Regulation Of Cellular Response To Stress Energy Homeostasis Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Protein Localization To Cell Periphery Positive Regulation Of Eukaryotic Translation Initiation Factor 4F Complex Assembly Regulation Of Presynapse Assembly	Formation Of Cytoplasmic Translation Initiation Complex Cytoplasmic Translational Initiation Translation Translational Initiation Regulation Of Translational Initiation IRES-dependent Viral Translational Initiation Viral Translational Termination-reinitiation
Pathways		ISG15 antiviral mechanism L13a-mediated translational silencing of Ceruloplasmin expression mTORC1-mediated signalling Deadenylation of mRNA Deadenylation of mRNA AUF1 (hnRNP D0) binds and destabilizes mRNA Translation initiation complex formation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) M-decay: degradation of maternal mRNAs by maternally stored factors Z-decay: degradation of maternal mRNAs by zygotically expressed factors	L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit
Drugs
Diseases
GWAS		Menarche (age at onset) ( 25231870) Red blood cell count ( 32888494)	Dimensional psychopathology (Social) ( 29496196)
Interacting Genes		42 interacting genes: A1CF ANXA5 ATPAF2 CCDC57 CDKN2D CENPU CIB1 CTBP2 DTX2 EIF1 EIF3A EIF3B EIF3I EIF4A1 EIF4A2 EIF4E EIF5 ENKD1 FXR2 GK HSPB1 HTRA2 HUNK KRT31 KRT34 MKNK1 MKNK2 NCBP1 NCBP2 NTAQ1 PABPC1 PAK2 PDCD4 PEF1 RNF10 SMARCD1 SRPK2 SUMO2 TRAF2 UBE3A UPF2 ZFYVE9	18 interacting genes: BRCA1 EIF3A EIF3G EIF3I EIF3J EIF4G1 GPRASP3 IL2RB LMO2 NDUFAB1 NF2 NREP PAIP1 PBX4 RPS6KB1 TBC1D23 TNNI1 UPF1
Entrez ID		1981	8662
HPRD ID		06774	06795
Ensembl ID		ENSG00000114867	ENSG00000106263
Uniprot IDs		B2RU06 B2RU10 B4DSI9 O95065 Q04637 Q96I65	P55884
PDB IDs		1LJ2 1UG3 2W97 4AZA 4F02 5EHC 5EI3 5EIR 5T46 5ZK5 6ZMW 8HUJ 8J7R 8OZ0	2KRB 2NLW 5K1H 6YBT 6ZMW 6ZON 6ZP4 6ZVJ 7A09 7QP6 7QP7 8OZ0 8PJ1 8PJ2 8PJ3 8PJ4 8PJ5 8PJ6 8XXN 9BLN
Enriched GO Terms of Interacting Partners?		Translational Initiation Translation Initiation Factor Activity Cytoplasmic Translational Initiation Post-transcriptional Regulation Of Gene Expression Regulation Of Translation RNA Binding Regulation Of Protein Metabolic Process Regulation Of Translational Initiation RNA Cap Binding Formation Of Cytoplasmic Translation Initiation Complex Eukaryotic 48S Preinitiation Complex Eukaryotic 43S Preinitiation Complex Cytosol Cytoplasm Eukaryotic Translation Initiation Factor 3 Complex, EIF3m Translation Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay MRNA Binding Cytoplasmic Stress Granule Eukaryotic Translation Initiation Factor 4F Complex RNA 7-methylguanosine Cap Binding Eukaryotic Translation Initiation Factor 3 Complex Macromolecule Metabolic Process Protein-RNA Complex Assembly MRNA Transport Regulation Of MRNA Metabolic Process RNA Cap Binding Complex Nuclear Cap Binding Complex Multi-eIF Complex MRNA Export From Nucleus Protein Metabolic Process Protein Binding RNA Transport SnRNA Export From Nucleus Regulation Of Primary Metabolic Process RNA Export From Nucleus Cytoplasmic Ribonucleoprotein Granule Positive Regulation Of MRNA 3'-end Processing Viral Translational Termination-reinitiation Regulation Of Gene Expression Calcium-dependent Protein Serine/threonine Kinase Activity Cap-dependent Translational Initiation Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Nuclear-transcribed MRNA Catabolic Process Regulation Of Metabolic Process Nucleobase-containing Compound Transport Nucleus Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Regulation Of MRNA 3'-end Processing	Cytoplasmic Translational Initiation Translational Initiation Translation Initiation Factor Activity Formation Of Cytoplasmic Translation Initiation Complex Eukaryotic Translation Initiation Factor 3 Complex Eukaryotic 48S Preinitiation Complex Eukaryotic 43S Preinitiation Complex Translation Viral Translational Termination-reinitiation Eukaryotic Translation Initiation Factor 3 Complex, EIF3m Protein-RNA Complex Assembly XY Body Regulation Of Translational Initiation Cytosol RNA Binding Positive Regulation Of Translation Behavioral Fear Response Behavioral Defense Response Fear Response Regulation Of Translation Positive Regulation Of Eukaryotic Translation Initiation Factor 4F Complex Assembly Acyl Carrier Activity
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