EIF4G1 and PDCD4

Number of citations of the paper that reports this interaction (PMID 12054647)
10

Data Source:
HPRD (in vitro)

		EIF4G1	PDCD4
Gene Name		eukaryotic translation initiation factor 4 gamma, 1	programmed cell death 4 (neoplastic transformation inhibitor)
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Gene Ontology Annotations	Cellular Component	Cytosol Membrane Eukaryotic Translation Initiation Factor 4F Complex	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Translation Initiation Factor Activity Protein Binding Translation Factor Activity, Nucleic Acid Binding Poly(A) RNA Binding	RNA Binding Protein Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening Translation Translational Initiation Regulation Of Translational Initiation Insulin Receptor Signaling Pathway Gene Expression Viral Process Cytokine-mediated Signaling Pathway Cellular Protein Metabolic Process	Apoptotic Process Cell Aging Negative Regulation Of JUN Kinase Activity Negative Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated
Pathways		Translation initiation complex formation IRS-mediated signalling mTOR signalling S6K1-mediated signalling mTOR signalling mTORC1-mediated signalling AUF1 (hnRNP D0) destabilizes mRNA IGF1R signaling cascade Deadenylation-dependent mRNA decay IRS-related events triggered by IGF1R Eukaryotic Translation Initiation S6K1 signalling Cap-dependent Translation Initiation PKB-mediated events PI3K Cascade Signaling by Insulin receptor Nonsense-Mediated Decay (NMD) Regulation of mRNA stability by proteins that bind AU-rich elements Insulin receptor signalling cascade Deadenylation of mRNA Translation ISG15 antiviral mechanism Interferon Signaling S6K1 signalling Cytokine Signaling in Immune system IRS-related events L13a-mediated translational silencing of Ceruloplasmin expression S6K1-mediated signalling Antiviral mechanism by IFN-stimulated genes mTORC1-mediated signalling Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S PKB-mediated events PI3K Cascade Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS
Protein-Protein Interactions		24 interactors: ANXA5 CENPU EIF3A EIF3B EIF3I EIF4A1 EIF4A2 EIF4E EIF5 GK HNRNPD HSPB1 HTRA2 MKNK1 MKNK2 NCBP1 NCBP2 PABPC1 PAK2 PDCD4 TRAF2 UBE3A UPF2 ZFYVE9	12 interactors: APOE BTRC CSNK2A1 EIF4A2 EIF4A3 EIF4G1 PSEN1 PSEN2 RPL5 RPLP1 RPS13 RPS6KA1
Entrez ID		1981	27250
HPRD ID		06774	10549
Ensembl ID		ENSG00000114867	ENSG00000150593
Uniprot IDs		B2RU06 B2RU10 B4DSI9 E7EUU4 E7EX73 E9PGM1 O95065 Q04637 Q96I65	B4DKX4 Q53EL6
PDB IDs		1LJ2 1UG3 2W97 4F02	2GGF 2KZT 2RG8 2ZU6 3EIJ
Enriched GO Terms of Interacting Partners?		Regulation Of Translation Regulation Of Translational Initiation Posttranscriptional Regulation Of Gene Expression Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process RNA Catabolic Process Translational Initiation Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process MRNA 3'-end Processing RNA 3'-end Processing Cellular Macromolecule Catabolic Process Aromatic Compound Catabolic Process Nuclear-transcribed MRNA Poly(A) Tail Shortening MRNA Metabolic Process Catabolic Process Viral Process Cellular Macromolecular Complex Assembly Nuclear Export MRNA Processing Regulation Of Gene Expression Translation Nucleocytoplasmic Transport Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear Transport Regulation Of Metabolic Process MRNA Export From Nucleus Ribonucleoprotein Complex Assembly Gene Expression RNA Export From Nucleus RNA Processing Formation Of Translation Preinitiation Complex Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay MRNA Transport RNA Transport Cellular Protein Metabolic Process RNA Localization Ribonucleoprotein Complex Biogenesis Regulation Of Cellular Process Gene Silencing By RNA Protein Metabolic Process Cytoplasmic Transport Cellular Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process MRNA Cis Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of MRNA 3'-end Processing	Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process RNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Catabolic Process Regulation Of Cellular Protein Metabolic Process Aromatic Compound Catabolic Process Cellular Macromolecule Catabolic Process Negative Regulation Of Cellular Metabolic Process Translational Initiation Regulation Of Protein Metabolic Process MRNA Metabolic Process Viral Process Nuclear-transcribed MRNA Poly(A) Tail Shortening Protein Metabolic Process Negative Regulation Of Cellular Protein Metabolic Process Posttranscriptional Regulation Of Gene Expression Cell Surface Receptor Signaling Pathway Cellular Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Positive Regulation Of Protein Catabolic Process Amyloid Precursor Protein Catabolic Process Regulation Of Translation MRNA 3'-end Processing Cellular Response To Organic Substance Viral Transcription Regulation Of Proteolysis Translation SRP-dependent Cotranslational Protein Targeting To Membrane Cotranslational Protein Targeting To Membrane Protein Targeting To ER Establishment Of Protein Localization To Endoplasmic Reticulum RNA 3'-end Processing Negative Regulation Of Catalytic Activity Protein Localization To Membrane Positive Regulation Of Cell Growth Beta-amyloid Metabolic Process Amyloid Precursor Protein Metabolic Process Protein Transport Regulation Of Protein Catabolic Process Protein Localization To Endoplasmic Reticulum Establishment Of Protein Localization Cellular Metabolic Process Membrane Protein Ectodomain Proteolysis Notch Receptor Processing Translational Termination Negative Regulation Of Apoptotic Process Regulation Of Catalytic Activity Positive Regulation Of Cellular Protein Catabolic Process
Tagcloud ?		bioinformatics box burkitt cacgtgt carrying cdk4 chip compelling consensus consequently copyright imidazole interesting k562 leukaemia myc myelogenous owing p493 pi polyamide promoters protected pyrrole qpcr rationale recognizes reserved rights	classes constituents cycling cyclins dexd dysregulation eif4a eif4a1 eif4b eif4e helicase helicases impede mcf7 microrna motors oncogenic otherwise pcdc4 polysome preferential quadruplexes ribosome structured translatome ubiquitous unwind unwinding utrs
Tagcloud (Difference) ?		bioinformatics box burkitt cacgtgt carrying cdk4 chip compelling consensus consequently copyright imidazole interesting k562 leukaemia myc myelogenous owing p493 pi polyamide promoters protected pyrrole qpcr rationale recognizes reserved rights	classes constituents cycling cyclins dexd dysregulation eif4a eif4a1 eif4b eif4e helicase helicases impede mcf7 microrna motors oncogenic otherwise pcdc4 polysome preferential quadruplexes ribosome structured translatome ubiquitous unwind unwinding utrs
Tagcloud (Intersection) ?