EIF4G1 and GK

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		EIF4G1	GK
Gene Name		eukaryotic translation initiation factor 4 gamma, 1	glycerol kinase
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Membrane Eukaryotic Translation Initiation Factor 4F Complex	Nucleus Mitochondrial Outer Membrane Cytosol Extracellular Vesicular Exosome
	Molecular Function	Translation Initiation Factor Activity Protein Binding Translation Factor Activity, Nucleic Acid Binding Poly(A) RNA Binding	Glycerol Kinase Activity Protein Binding ATP Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening Translation Translational Initiation Regulation Of Translational Initiation Insulin Receptor Signaling Pathway Gene Expression Viral Process Cytokine-mediated Signaling Pathway Cellular Protein Metabolic Process	Glycerol Metabolic Process Triglyceride Metabolic Process Phosphorylation Triglyceride Biosynthetic Process Glycerol Catabolic Process Glucose Homeostasis Cellular Lipid Metabolic Process Small Molecule Metabolic Process Glycerol-3-phosphate Biosynthetic Process
Pathways		Translation initiation complex formation IRS-mediated signalling mTOR signalling S6K1-mediated signalling mTOR signalling mTORC1-mediated signalling AUF1 (hnRNP D0) destabilizes mRNA IGF1R signaling cascade Deadenylation-dependent mRNA decay IRS-related events triggered by IGF1R Eukaryotic Translation Initiation S6K1 signalling Cap-dependent Translation Initiation PKB-mediated events PI3K Cascade Signaling by Insulin receptor Nonsense-Mediated Decay (NMD) Regulation of mRNA stability by proteins that bind AU-rich elements Insulin receptor signalling cascade Deadenylation of mRNA Translation ISG15 antiviral mechanism Interferon Signaling S6K1 signalling Cytokine Signaling in Immune system IRS-related events L13a-mediated translational silencing of Ceruloplasmin expression S6K1-mediated signalling Antiviral mechanism by IFN-stimulated genes mTORC1-mediated signalling Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S PKB-mediated events PI3K Cascade Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Triglyceride Biosynthesis
Drugs
Diseases
GWAS
Protein-Protein Interactions		24 interactors: ANXA5 CENPU EIF3A EIF3B EIF3I EIF4A1 EIF4A2 EIF4E EIF5 GK HNRNPD HSPB1 HTRA2 MKNK1 MKNK2 NCBP1 NCBP2 PABPC1 PAK2 PDCD4 TRAF2 UBE3A UPF2 ZFYVE9	11 interactors: AOX1 APCS CLPTM1L CYP3A4 EIF4G1 FBXO28 GPD1 IPO13 NR4A1 OPLAH RXRA
Entrez ID		1981	2710
HPRD ID		06774	08363
Ensembl ID		ENSG00000114867	ENSG00000198814
Uniprot IDs		B2RU06 B2RU10 B4DSI9 E7EUU4 E7EX73 E9PGM1 O95065 Q04637 Q96I65	B4DH54 P32189
PDB IDs		1LJ2 1UG3 2W97 4F02
Enriched GO Terms of Interacting Partners?		Regulation Of Translation Regulation Of Translational Initiation Posttranscriptional Regulation Of Gene Expression Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process RNA Catabolic Process Translational Initiation Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process MRNA 3'-end Processing RNA 3'-end Processing Cellular Macromolecule Catabolic Process Aromatic Compound Catabolic Process Nuclear-transcribed MRNA Poly(A) Tail Shortening MRNA Metabolic Process Catabolic Process Viral Process Cellular Macromolecular Complex Assembly Nuclear Export MRNA Processing Regulation Of Gene Expression Translation Nucleocytoplasmic Transport Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear Transport Regulation Of Metabolic Process MRNA Export From Nucleus Ribonucleoprotein Complex Assembly Gene Expression RNA Export From Nucleus RNA Processing Formation Of Translation Preinitiation Complex Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay MRNA Transport RNA Transport Cellular Protein Metabolic Process RNA Localization Ribonucleoprotein Complex Biogenesis Regulation Of Cellular Process Gene Silencing By RNA Protein Metabolic Process Cytoplasmic Transport Cellular Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process MRNA Cis Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of MRNA 3'-end Processing	Vitamin Metabolic Process Regulation Of Translational Initiation Glycerophosphate Shuttle Cellular Response To Organic Cyclic Compound Negative Regulation By Host Of Viral Exo-alpha-sialidase Activity Negative Regulation By Host Of Viral Glycoprotein Metabolic Process Positive Regulation Of Translational Initiation By Iron Negative Regulation Of Exo-alpha-sialidase Activity Steroid Hormone Mediated Signaling Pathway Cellular Nitrogen Compound Metabolic Process Alkaloid Catabolic Process Hormone-mediated Signaling Pathway Xenobiotic Metabolic Process Small Molecule Metabolic Process Cellular Response To Xenobiotic Stimulus Cellular Response To Hormone Stimulus Secretory Columnal Luminar Epithelial Cell Differentiation Involved In Prostate Glandular Acinus Development Response To Xenobiotic Stimulus Vitamin B6 Metabolic Process Glycerol-3-phosphate Catabolic Process Nitrogen Compound Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Monoterpenoid Metabolic Process NADH Oxidation Peroxisome Proliferator Activated Receptor Signaling Pathway Calcitriol Biosynthetic Process From Calciol Cellular Response To Steroid Hormone Stimulus Negative Regulation Of Monocyte Differentiation Intracellular Receptor Signaling Pathway DNA-templated Transcription, Initiation Response To Stimulus Regulation Of Branching Involved In Prostate Gland Morphogenesis Alkaloid Metabolic Process Steroid Metabolic Process Glycerol-3-phosphate Metabolic Process Response To Organic Cyclic Compound Cellular Response To Organic Substance Positive Regulation Of Glycolytic Process Negative Regulation Of Glycoprotein Metabolic Process Regulation Of Translation Oxidative Demethylation Chaperone-mediated Protein Complex Assembly Vitamin D Metabolic Process Muscle Organ Development Response To Hormone Regulation Of Monocyte Differentiation Positive Regulation Of Translational Initiation Endothelial Cell Chemotaxis Negative Regulation Of Acute Inflammatory Response Cellular Lipid Metabolic Process
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Tagcloud (Difference) ?		bioinformatics box burkitt cacgtgt carrying cdk4 chip compelling consensus consequently copyright imidazole interesting k562 leukaemia myc myelogenous owing p493 pi polyamide promoters protected pyrrole qpcr rationale recognizes reserved rights	cask channels clustering coclusters coimmunoprecipitates colocalizes constituent cooh enzymatic fact gkap guanylate heterologous homology isolation junction lin maguk nh2 obscure organization pdz postsynaptic psd sap90 sh3 synaptic termed zo
Tagcloud (Intersection) ?