POLR2C and CCHCR1

Number of citations of the paper that reports this interaction (PMID 16141233)
6

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo, two hybrid)

		POLR2C	CCHCR1
Gene Name		polymerase (RNA) II (DNA directed) polypeptide C, 33kDa	coiled-coil alpha-helical rod protein 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm DNA-directed RNA Polymerase II, Core Complex Cytoplasm Microtubule Cytoskeleton	Nucleus Cytoplasm Centriole
	Molecular Function	RNA Polymerase II Activity DNA Binding Protein Dimerization Activity
	Biological Process	MRNA Splicing, Via Spliceosome DNA Repair Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter 7-methylguanosine MRNA Capping RNA Splicing Gene Expression Viral Process PiRNA Metabolic Process Somatic Stem Cell Maintenance Positive Regulation Of Viral Transcription	Protein Export From Nucleus Multicellular Organismal Development Cell Differentiation
Pathways		RNA Polymerase II Promoter Escape mRNA Splicing Formation of HIV-1 elongation complex containing HIV-1 Tat PIWI-interacting RNA (piRNA) biogenesis Nucleotide Excision Repair RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Abortive elongation of HIV-1 transcript in the absence of Tat HIV Infection Regulatory RNA pathways Formation of the Early Elongation Complex Tat-mediated elongation of the HIV-1 transcript Tat-mediated HIV elongation arrest and recovery Formation of transcription-coupled NER (TC-NER) repair complex RNA Pol II CTD phosphorylation and interaction with CE RNA Polymerase II Pre-transcription Events Dual incision reaction in TC-NER Influenza Life Cycle HIV elongation arrest and recovery HIV Life Cycle HIV Transcription Initiation Influenza Viral RNA Transcription and Replication RNA Pol II CTD phosphorylation and interaction with CE Transcriptional regulation of pluripotent stem cells RNA Polymerase II HIV Promoter Escape HIV Transcription Elongation POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation Transcriptional regulation by small RNAs Processing of Capped Intron-Containing Pre-mRNA mRNA Capping mRNA Splicing - Minor Pathway mRNA Splicing - Major Pathway MicroRNA (miRNA) biogenesis Influenza Infection Pausing and recovery of Tat-mediated HIV elongation Late Phase of HIV Life Cycle Formation of RNA Pol II elongation complex RNA Polymerase II Transcription Initiation And Promoter Clearance Pausing and recovery of HIV elongation Formation of HIV elongation complex in the absence of HIV Tat Transcription-coupled NER (TC-NER) Viral Messenger RNA Synthesis Formation of the HIV-1 Early Elongation Complex RNA Polymerase II Transcription Initiation Transcription of the HIV genome RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS			Chronic obstructive pulmonary disease-related biomarkers ( 23144326) Hematology traits ( 23263863) Nevirapine-induced rash ( 21810746) Prostate cancer ( 21743467) Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS-TEN) ( 21912425) White blood cell count ( 21738480)
Protein-Protein Interactions		26 interactors: ATF4 ATF7IP C11orf58 C14orf1 CCHCR1 EEF1A1 ITCH LRIF1 MYOG NEDD4 NFKBIA NUDT21 POLR2A POLR2B POLR2D POLR2E POLR2F POLR2G POLR2H POLR2J POLR2K POLR2L SMARCC2 STC2 TAF15 UBE2W	57 interactors: ABI2 ALAS1 AMOTL2 ATG5 BLOC1S6 C1orf94 CARD9 CCDC102B CCDC136 CCDC53 CDR2 CEP55 CTAGE5 DTNBP1 EFHC2 FSD2 GOLGA2 HAUS1 HSBP1 IKBKG KRT13 KRT15 KRT31 KRT40 MAD1L1 MED4 MID2 MTUS2 NAB2 NDC80 NDEL1 NINL NME7 NUP62 NUTM1 PIAS2 POLD2 POLR2C PRKCG RBM17 SAT1 SPAG5 SSX2IP STAR TADA2A TEKT1 TFIP11 TPM3 TRAF1 TRAF2 TRAF4 TRIM27 TSGA10 TXLNA TXLNB USHBP1 ZFYVE19
Entrez ID		5432	54535
HPRD ID		15945	05607
Ensembl ID		ENSG00000102978	ENSG00000204536
Uniprot IDs		P19387 Q6FGR6	B0S7V6 D2IYK9 M1T2K8 M1TIV4 Q2TB68 Q769H0 Q8TD31
PDB IDs
Enriched GO Terms of Interacting Partners?		7-methylguanosine MRNA Capping PiRNA Metabolic Process 7-methylguanosine RNA Capping Transcription Elongation From RNA Polymerase II Promoter Transcription-coupled Nucleotide-excision Repair Positive Regulation Of Viral Transcription DNA-templated Transcription, Elongation Somatic Stem Cell Maintenance Regulation Of Viral Transcription Positive Regulation Of Viral Process Viral Process Nucleotide-excision Repair Transcription Initiation From RNA Polymerase II Promoter DNA-templated Transcription, Initiation MRNA Splicing, Via Spliceosome Stem Cell Maintenance RNA Splicing, Via Transesterification Reactions Regulation Of Viral Process RNA Splicing Transcription From RNA Polymerase II Promoter Stem Cell Development Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression MRNA Processing Transcription, DNA-templated Positive Regulation Of Cellular Biosynthetic Process Stem Cell Differentiation RNA Biosynthetic Process MRNA Metabolic Process Cellular Response To Stress Termination Of RNA Polymerase III Transcription Transcription Elongation From RNA Polymerase III Promoter RNA Processing DNA Repair Regulation Of Type I Interferon Production NcRNA Metabolic Process Termination Of RNA Polymerase I Transcription Transcription Elongation From RNA Polymerase I Promoter Regulation Of Gene Expression RNA Metabolic Process Negative Regulation Of Cell Differentiation Transcription Initiation From RNA Polymerase I Promoter Regulation Of RNA Biosynthetic Process DNA-templated Transcription, Termination Regulation Of RNA Metabolic Process Transcription From RNA Polymerase I Promoter Positive Regulation Of Type I Interferon Production DNA Metabolic Process Positive Regulation Of Metabolic Process Gene Expression	Mitotic Cell Cycle Mitotic Cell Cycle Process Microtubule-based Transport Activation Of NF-kappaB-inducing Kinase Activity Cytoskeleton-dependent Intracellular Transport Organelle Organization Positive Regulation Of NIK/NF-kappaB Signaling Cell Cycle Process NIK/NF-kappaB Signaling Mitotic Nuclear Division Cell Cycle Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Microtubule-based Process Positive Regulation Of NF-kappaB Transcription Factor Activity Axon Cargo Transport Innate Immune Response Cell Division Positive Regulation Of Protein Homodimerization Activity Cytoskeleton Organization Microtubule-based Movement Establishment Of Organelle Localization Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Viral Transcription Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Viral Release From Host Cell Establishment Of Vesicle Localization Intracellular Receptor Signaling Pathway Anterograde Synaptic Vesicle Transport Negative Regulation Of Neuron Death Vesicle Localization Regulation Of Protein Homodimerization Activity Centrosome Organization Negative Regulation Of Viral Transcription Melanosome Organization Establishment Of Localization In Cell Pigment Granule Organization Regulation Of Viral Release From Host Cell Regulation Of I-kappaB Kinase/NF-kappaB Signaling Developmental Process Organelle Localization Microtubule Organizing Center Organization Cellular Localization Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Anterograde Axon Cargo Transport Regulation Of Apoptotic Process Microtubule Cytoskeleton Organization Positive Regulation Of JNK Cascade Spindle Organization Regulation Of Cell Death
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