POLR2C and SMARCC2

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
HPRD (two hybrid)

		POLR2C	SMARCC2
Description		RNA polymerase II subunit C	SWI/SNF related BAF chromatin remodeling complex subunit C2
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GO Annotations	Cellular Component	DNA-directed RNA Polymerase Complex Nucleus Nucleoplasm RNA Polymerase II, Core Complex Cytosol	Kinetochore Chromatin Nucleus Nucleoplasm Nuclear Matrix SWI/SNF Complex RSC-type Complex Protein-containing Complex Brahma Complex NpBAF Complex NBAF Complex BBAF Complex
	Molecular Function	DNA Binding DNA-directed RNA Polymerase Activity Protein Binding Protein Dimerization Activity	Transcription Coactivator Activity Protein Binding Nucleosomal DNA Binding Histone Binding
	Biological Process	DNA-templated Transcription Transcription By RNA Polymerase II	Chromatin Organization Nucleosome Disassembly Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Nervous System Development Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of T Cell Differentiation Positive Regulation Of Cell Differentiation Positive Regulation Of Myoblast Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Regulation Of G0 To G1 Transition Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Double-strand Break Repair Regulation Of Nucleotide-excision Repair
Pathways		Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Abortive elongation of HIV-1 transcript in the absence of Tat Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation Viral Messenger RNA Synthesis MicroRNA (miRNA) biogenesis Transcriptional regulation by small RNAs PIWI-interacting RNA (piRNA) biogenesis Activation of anterior HOX genes in hindbrain development during early embryogenesis RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes FGFR2 alternative splicing RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes mRNA Capping mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Pol II CTD phosphorylation and interaction with CE Signaling by FGFR2 IIIa TM Estrogen-dependent gene expression Inhibition of DNA recombination at telomere	RMTs methylate histone arginines RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of MITF-M-dependent genes involved in pigmentation Regulation of MITF-M-dependent genes involved in pigmentation Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Formation of the polybromo-BAF (pBAF) complex Formation of the embryonic stem cell BAF (esBAF) complex Formation of the non-canonical BAF (ncBAF) complex Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)
Drugs
Diseases
GWAS			Asthma ( 31619474) Refractive error ( 32231278)
Interacting Genes		32 interacting genes: ATF4 ATF7IP C11orf58 CCHCR1 EEF1A1 ERG28 ITCH LRIF1 MYOG NECAB2 NEDD4 NFKBIA NUDT21 OTUD5 POLR2A POLR2B POLR2D POLR2E POLR2F POLR2G POLR2H POLR2J POLR2J2 POLR2K POLR2L RPAP1 RSPH1 SMARCC2 STC2 TAF15 UBC UBE2W	27 interacting genes: ARRB2 ATXN1 ATXN1L BAZ1B CEBPA CSNK2A1 EWSR1 FUS GATA1 IFTAP ITCH ITSN1 KLF1 KRT27 MCPH1 NOVA1 PEX14 PHYHIP POLR2C RAB1B RBPMS RELB SP1 SRGAP3 TAF15 TERF1 USP7
Entrez ID		5432	6601
HPRD ID		15945	03437
Ensembl ID		ENSG00000102978	ENSG00000139613
Uniprot IDs		P19387 Q6FGR6	F8VXC8 Q8TAQ2
PDB IDs		5IY6 5IY7 5IY8 5IY9 5IYA 5IYB 5IYC 5IYD 6DRD 6O9L 6XRE 7LBM 9EHZ 9EI1 9EI3 9EI4	6KAG 6LTH 6LTJ 7VDV 7Y8R
Enriched GO Terms of Interacting Partners?		RNA Polymerase II, Core Complex DNA-directed RNA Polymerase Complex DNA-directed RNA Polymerase Activity Transcription By RNA Polymerase II DNA-templated Transcription RNA Polymerase I Complex RNA Polymerase III Complex Nucleobase-containing Compound Biosynthetic Process Macromolecule Biosynthetic Process Nucleus RNA Metabolic Process Nucleoplasm Nucleic Acid Metabolic Process Transcription By RNA Polymerase III TRNA Transcription By RNA Polymerase III TRNA Transcription Nucleobase-containing Compound Metabolic Process RNA-directed RNA Polymerase Activity RNA-templated Transcription Macromolecule Metabolic Process DNA Binding Regulation Of Transcription By RNA Polymerase I 5'-3' RNA Polymerase Activity Protein Monoubiquitination Nucleolus Transcription By RNA Polymerase I Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Nucleotidyltransferase Activity Translation Initiation Factor Binding Negative Regulation Of Gene Expression Negative Regulation Of Potassium Ion Transport	Nucleoplasm Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Symbiont-mediated Disruption Of Host Cell PML Body Regulation Of Gene Expression Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process POZ Domain Binding Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Establishment Of Protein Localization To Telomere DNA-templated Transcription Nucleus Identical Protein Binding MRNA 3'-UTR Binding Regulation Of Establishment Of Protein Localization To Chromosome Negative Regulation Of Macromolecule Biosynthetic Process Nucleolus Transcription By RNA Polymerase II Negative Regulation Of Biosynthetic Process Transcription Repressor Complex Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Molecular Adaptor Activity Regulation Of Chromosome Condensation Negative Regulation Of RNA Metabolic Process DNA Binding Myeloid Cell Apoptotic Process Macromolecule Biosynthetic Process Regulation Of Hematopoietic Stem Cell Proliferation Positive Regulation Of RNA Metabolic Process Nucleobase-containing Compound Biosynthetic Process Postsynapse Regulation Of Chromosome Organization Myeloid Cell Differentiation Rhythmic Process Transcription Cis-regulatory Region Binding Nucleic Acid Metabolic Process Chromatin Binding Granulocyte Differentiation Memory Regulation Of Transcription By RNA Polymerase II
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